Low‑doses of aspirin promote the growth of human PC‑9 lung cancer cells through activation of the MAPK family

Qian, Yue; Dai, Huanyun; Li, Hongyu

doi:10.3892/etm.2021.10875

Cited by 4 publications

(3 citation statements)

References 31 publications

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“…Due to aberrant activation of cell cycle components, cancers exhibit deregulated cell proliferation 25 . Therefore, one of the key indicators for demonstrating the efficacy of anticancer effect is to determine whether a candidate anticancer agent induces cell cycle arrest, particularly S-phase arrest 26 , 27 .…”

Section: Resultsmentioning

confidence: 99%

Chemical screening identifies the anticancer properties of Polyporous tuberaster

Song¹,

So²,

Park³

et al. 2023

J. Cancer

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Most conventional anticancer drugs cause resistance to chemotherapy, which has emerged as one of the major obstacles to cancer treatment. In order to address this issue, efforts have been made to select new anticancer compounds from natural sources. The aim of this study is to identify novel anticancer compounds from mycelial culture extracts belonging to Polyporus tuberaster (P. tuberaster). Here, we found that mycelial culture extracts of P. tuberaster cultured in PDB medium (pt-PDB) effectively inhibited cancer cell growth. pt-PDB reduced the growth of cancer cells through apoptosis induction and S-phase arrest. The anticancer efficacy of pt-PDB was not to limited to one type of cancer. Furthermore, unlike traditional anticancer medications, pt-PDB did not increase the proportion of side population (SP) cells, which plays a key role in the development of chemoresistance. Taken together, we discovered a novel anticancer drug candidate that has anticancer properties without increasing the proportion of SP cells. This new drug candidate can be used for the treatment of cancer, especially chemoresistant malignancies, and will provide a breakthrough in the treatment of chemoresistant cancer.

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Section: Resultsmentioning

confidence: 99%

Chemical screening identifies the anticancer properties of Polyporous tuberaster

Song¹,

So²,

Park³

et al. 2023

J. Cancer

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“…p38 MAPK and STAT3 signalling are activated in most of cancer cells and participate in cancer cell proliferation and metastases 21,22 . Suppression of p38 MAPK and STAT3 activation was associated with reduced lung cancer growth in vitro and in animal models 23,24 .…”

Section: Introductionmentioning

confidence: 99%

“…20 p38 MAPK and STAT3 signalling are activated in most of cancer cells and participate in cancer cell proliferation and metastases. 21,22 Suppression of p38 MAPK and STAT3 activation was associated with reduced lung cancer growth in vitro and in animal models. 23,24 However, the role and downstream signalling pathways of SIRPα in the progression of lung cancer are not well studied so far.…”

mentioning

confidence: 99%

Lack of SIRP‐alpha reduces lung cancer growth in mice by promoting anti‐tumour ability of macrophages and neutrophils

et al. 2022

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Objectives: Signal regulatory protein-alpha (SIRPα) is a transmembrane glycoprotein specifically expressed on myeloid cells. Blockade of SIRPα/CD47 interaction is effective in combinational therapy of some cancers. This study aimed to explore into the role and underlying molecular mechanisms of SIRPα in lung cancer growth. Materials and Methods: A mouse model with lung cancer in wild-type (WT) and SIRPα-knockout mouse (KO) mice was established by subcutaneous injection of Lewis murine lung cancer cells (LLC). Circulating monocytes and neutrophils were depleted in mice by intraperitoneal administration of clodronate liposomes and anti-Ly6G antibody, respectively. Phenotypes and phagocytosis of macrophages and neutrophils were analysed by flow cytometry. Transwell assay was used to analyse LLC cells migration and invasion. Results: Lack of SIRPα inhibited LLC cells growth in KO mice, associated with reduced infiltrating PD-1 + CD8 + T cells and production of IL-6 from infiltrating macrophages and neutrophils in tumour tissues. Depletion of circulating monocytes and neutrophils reduced LLC cells growth in WT mice, which was abolished in KO mice. Studies in vitro showed that lack of SIRPα increased M1/M2 ratio, and reduced LLC cell migration and invasion via attenuated IL-6 secretion. Lack of SIRPα expression in neutrophils effectively increased the cytotoxic activity to LLC cells in vitro. Conclusions: Lack of SIRPα suppressed lung cancer cell growth in mice, dependent on circulating macrophages and neutrophils, in association with improved phagocytosis and reduced IL-6 expression. | INTRODUCTIONLung cancer ranks first in mortality and second in the prevalence of malignant cancer worldwide in 2021. 1 To date, targeting immune checkpoints such as programmed death-1 (PD-1), and cytolytic T lymphocyte-associated antigen-4 (CTLA-4), have become effective therapeutic approaches among some lung cancer patients. 2,3 However, cohorts of patients have developed immune resistance to the immune checkpoint inhibitors (ICIs), due to infiltration of tumourassociated macrophages and neutrophils (TAMs and TANs), immunosuppressive myeloid cells and induction of T cell exclusion. [4][5][6] In addition, IL-6 is up-regulated in most of tumour patients and plays an important role in the modulation of these immunosuppressive cells. 7,8 It was previously reported that the combined blockade of IL-6 and Linyue Pan and Bin Wang contributed equally to this study.

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Combination Supplements for Endometrial Cancer

Mondal,

Lahiri,

Vundavilli

et al. 2023

2023 IEEE 23rd International Conference on Bioinformatics and Bioengineering (BIBE)

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Low‑doses of aspirin promote the growth of human PC‑9 lung cancer cells through activation of the MAPK family

Cited by 4 publications

References 31 publications

Chemical screening identifies the anticancer properties of Polyporous tuberaster

Chemical screening identifies the anticancer properties of Polyporous tuberaster

Lack of SIRP‐alpha reduces lung cancer growth in mice by promoting anti‐tumour ability of macrophages and neutrophils

Combination Supplements for Endometrial Cancer

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