Low doses of ethanol may induce anti‐nociceptive effects via an oxytocinergic mechanism

Uvnäs‐Moberg, Kerstin; Lundeberg, Thomas; Bruzelius, G.; Alster, Pawel

doi:10.1111/j.1748-1716.1993.tb09599.x

Cited by 5 publications

(3 citation statements)

References 8 publications

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“…Also the attachment between infant and mother may in a primitive sense be linked to oxytocin release caused by suckling. It is even possible that the dependency of other types of suckling related behaviors, e.g., smoking of cigarettes and even drinking of alcohol ( Uvnäs-Moberg et al, 1993b ), may involve an oxytocin linked component triggered by the suckling itself and not only by the pharmacological effects of nicotine and alcohol.…”

Section: Oxytocin Release In Response To Food Intakementioning

confidence: 99%

Self-soothing behaviors with particular reference to oxytocin release induced by non-noxious sensory stimulation

2015

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Oxytocin, a hypothalamic nonapeptide, is linked to increased levels of social interaction, well-being and anti-stress effects. The effects of oxytocin that is released by sensory stimulation during different kinds of interactive behaviors are often underestimated or even forgotten. In fact, many of the positive effects caused during interaction, such a wellbeing, stress reduction and even health promotion, are indeed linked to oxytocin released in response to activation of various types of sensory nerves. Oxytocin is released in response to activation of sensory nerves during labor, breastfeeding and sexual activity. In addition oxytocin is released in response to low intensity stimulation of the skin, e.g., in response to touch, stroking, warm temperature, etc. Consequently oxytocin is not only released during interaction between mothers and infants, but also during positive interaction between adults or between humans and animals. Finally oxytocin is also released in response to suckling and food intake. Oxytocin released in the brain in response to sensory stimulation as a consequence of these types of interactive behaviors, contributes to every day wellbeing and ability to handle stress. Food intake or sex may be used or even abused to achieve oxytocin-linked wellbeing and stress relief to compensate for lack of good relationships or when the levels of anxiety are high. The present review article will summarize the role played by oxytocin released by sensory (in particular somatosensory) stimulation, during various kinds of interactive behaviors. Also the fact that the anti-stress effects of oxytocin are particularly strong when oxytocin is released in response to “low intensity” stimulation of the skin will be highlighted.

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Section: Oxytocin Release In Response To Food Intakementioning

confidence: 99%

Self-soothing behaviors with particular reference to oxytocin release induced by non-noxious sensory stimulation

2015

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“…Urnäs-Moberg and coworkers (15) postulated that low doses of ethanol could cause anti-nociceptive effects via an oxytocinergic mechanism. Administration of ethanol also stimulated the elevation in plasma OT levels and the use of OT-ANT reduced the increased pain threshold produced by ethanol.…”

Section: Oxytocinmentioning

confidence: 99%

“…Administration of ethanol also stimulated the elevation in plasma OT levels and the use of OT-ANT reduced the increased pain threshold produced by ethanol. However, Urnäs-Moberg and colleagues (15) made a statement that "opioid mechanisms do not seem to be involved in the oxytocin induced effects on pain threshold, since the effects are not blocked by naloxone (Lundeberg, personal communication)." The results of the mentioned experiment was not published neither the doses or the study design, as far as we know.…”

Section: Oxytocinmentioning

confidence: 99%

Pain and the endogenous antinociceptive neuronal system: physiologic role of oxytocin

Valênça¹,

Andrade-Valença²,

Antunes‐Rodrigues³

2011

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The unpleasant pain sensation is a sub-modality of somatic sensation that exerts fundamental warning and protective functions. Pain is the more frequent complain in a neurological outpatient clinic. In a series of 200 consecutive patients in a neurological outpatient clinic, 51% of them complained of some type of pain, the more frequents were headache and carpal tunnel syndrome. The role of oxytocin in pain regulation was reviewed. It seems that oxytocin may play a major role in the mechanism of pain regulation, particularly through the endogenous antinociceptive neuronal system.

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Anti-nociceptive effects of oxytocin in rats and mice

Lundeberg

Uvnäs‐Moberg

Ågren

et al. 1994

Neuroscience Letters

133

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Low doses of ethanol may induce anti‐nociceptive effects via an oxytocinergic mechanism

Cited by 5 publications

References 8 publications

Self-soothing behaviors with particular reference to oxytocin release induced by non-noxious sensory stimulation

Self-soothing behaviors with particular reference to oxytocin release induced by non-noxious sensory stimulation

Pain and the endogenous antinociceptive neuronal system: physiologic role of oxytocin

Anti-nociceptive effects of oxytocin in rats and mice

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