Low doses of ipsapirone increase growth hormone but not oxytocin secretion in normal male and female subjects

Newman, Morris; Li, Q.; Gelfin, Yevgenia; Kar, Louis D. Van de; Lerer, Bernard

doi:10.1007/s002130051037

Cited by 8 publications

(4 citation statements)

References 20 publications

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“…The very significant increase in GH after flesinoxan completely parallels those reported by Seletti et al (1995) and is consistent with studies using other 5-HT 1A agonists such as ipsapirone, gepirone or tandospirone to stimulate GH response (Lesch et al 1989;Anderson et al 1990;Miller et al 1990;Cleare et al 1998;Newman et al 1999;Cleare and Bond 2000). This hormonal effect appears to be mediated through the stimulation of post-synaptic 5-HT 1A receptors (Seletti et al 1995).…”

Section: Discussionsupporting

confidence: 85%

“…Stimulation of the hypothalamo-pituitary-adrenal axis (HPA) by the 5-HT 1A agonist ipsapirone has been demonstrated in several studies (Kahn et al 1994;Meltzer and Maes 1995a;Gelfin et al 1995;Cleare et al 1998;Schwartz et al 1999). Ipsapirone also stimulates the hypothalamic-GH axis (Lesch et al 1989;Cleare et al 1998;Newman et al 1999;Cleare and Bond 2000), as does tandospirone (Miller et al 1990) and gepirone (Anderson et al 1990). However, these 5-HT 1A compounds are partial agonists that may have agonist or antagonist activities and most of them are metabolized into 1-phenylpiperazine (1-PP), an alpha 2 -adrenoreceptor antagonist.…”

Section: Introductionmentioning

confidence: 99%

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Hormonal and temperature responses to the 5-HT 1A receptor agonist flesinoxan in normal volunteers

Pitchot¹,

Wauthy²,

Hansenne³

et al. 2002

Psychopharmacology

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Rationale: Flesinoxan is a highly potent and selective 5-HT 1A agonist and appears to be a potentially interesting neuroendocrine serotonergic probe. Objectives: We assessed hormonal (ACTH, cortisol, prolactin and growth hormone) and temperature responses to flesinoxan in normal volunteers. Methods: In a doubleblind placebo-controlled study, single doses of 0.5 mg and 1 mg were injected over 10 min into 12 healthy male volunteers at 1-week intervals. Temperature and hormonal responses were measured at times -30, 0, 15, 30, 60, 90, and 120 min. Results: Flesinoxan induced a significant and dose-dependent increase in adrenocorticotropic hormone (ACTH), cortisol, prolactin (PRL), growth hormone (GH) and a decrease in body temperature. Tolerance to flesinoxan was excellent. Conclusions: These results showed the role of 5-HT 1A mechanisms in the PRL, ACTH, cortisol, GH, and temperature responses to flesinoxan. In the present study, flesinoxan appears a very promising serotonergic neuroendocrine probe.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Hormonal and temperature responses to the 5-HT 1A receptor agonist flesinoxan in normal volunteers

Pitchot¹,

Wauthy²,

Hansenne³

et al. 2002

Psychopharmacology

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“…It appears that these binding differences have functional consequences. Ipsapirone, a 5-HT 1A partial agonist, stimulates GH secretion more in male than in female subjects indicating greater responsivity in females (Newman et al, 1999). Animal studies suggest different 5-HT 1A responses in males and females (Gelfin et al, 1995;Ebenezer and Tite, 1994;Haleem et al, 1989Haleem et al, , 1990Joppa et al, 1997;Uphouse et al, 1991;Mendelson and McEwen, 1991;Curzon, 1989).…”

Section: Effect Of Sexmentioning

confidence: 99%

Serotonin-1A autoreceptor binding in the dorsal raphe nucleus of depressed suicides

Boldrini

Underwood

Mann

et al. 2008

Journal of Psychiatric Research

167

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Serotonergic dysfunction is present in mood disorders and suicide. Brainstem 5-HT1A somatodendritic autoreceptors regulate serotonin neuron firing but studies of autoreceptor binding in the dorsal raphe nucleus (DRN) in depressed suicides report conflicting results. We sought to determine: (1) the anatomical distribution of 5-HT1A receptor binding in the DRN in depressed suicides and psychiatrically normal controls; and (2) whether sex differences in 5-HT1A binding in the DRN contribute to differences between depressed suicides and controls. Previously collected quantitative receptor autoradiograms of [3H]8-hydroxy-2-(di-n-propyl)aminotetralin (3H-8-OH-DPAT) in postmortem tissue sections containing the DRN from drug-free suicide victims (n=10) and matched controls (n=10) were analyzed. Less total receptor binding (fmol/mg tissuexmm3) was observed in the entire DRN in depressed suicides compared with controls (p<0.05). Group differences along the rostrocaudal extent of the DRN were observed for cross-sectional 5-HT(1A) binding (fmol/mg tissue) and receptor binding (fmol/mgxmm3, p<0.05). Cross-sectional 5-HT1A DRN binding in depressed suicides compared with controls was higher rostrally and lower caudally. The differences between depressed suicides and controls were present in males and females, although females had more binding than males. Less autoreceptor binding in the DRN of depressed suicides may represent a homeostatic response to less serotonin release, increasing serotonin neuron firing. More autoreceptor binding in rostral DRN might contribute to deficient serotonin release in ventromedial prefrontal cortex by lower neuronal firing.

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“…This innervation from the PVN onto dopaminergic neurons is important for social reward [ 10,11 ]. Similarly, there is evidence that vasopressin interacts with the dopaminergic system in the lateral septum [ 12,13 ] to moderate social play in a sex-speci c manner [ 14 ]. Therefore, this raises the possibility that the oxytocin and vasopressin systems might be involved in the behavioural response to tickling, in a sexually dimorphic manner.…”

Section: Introductionmentioning

confidence: 99%

Tickling of rats is associated with positive affective states, but does not replicate juvenile social play regarding the involvement of central oxytocin and vasopressin systems

Tivey,

Martin,

Brown

et al. 2024

Preprint

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Tickling of rats is a widely used positive handling habituation technique that was modelled on conspecific social (rough and tumble) play. Any neuroendocrine response to tickling has yet to be explored. We aimed to test the hypothesis that as in conspecific play, oxytocin and vasopressin neurons in the paraventricular nucleus (PVN) and supraoptic nucleus (SON) of the hypothalamus are involved in regulating the behavioural response to tickling in female and male juvenile Wistar rats. Rats (n=32/sex) received either tickling (Tickled, n=16/sex) or no hand contact (Controls, n=16/sex). Play behaviours (hand approaches and scampering), 50 kHz and 22 kHz ultrasonic vocalisations (USVs) were quantified. Immediate early gene expression (Fos immunoreactivity; Fos-ir) in oxytocinergic and vasopressinergic neurons of the PVN and SON was quantified. We found that tickled rats called more than controls and that tickled females produced more 50 kHz USVs than tickled male or control rats. In the parvocellular PVN we found that tickled rats, regardless of sex, had lower expression of Fos-ir in oxytocin and vasopressin neurons. In contrast, there was no effect of tickling on the number of Fos-ir magnocellular oxytocin or vasopressin neurons in the PVN or SON. Our findings provide the first evidence that tickling does not replicate the involvement of the central oxytocin and vasopressin systems previously reported following social play in juvenile rats. This is an important consideration for future interpretation of central oxytocin and vasopressin in response to tickling.

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Low doses of ipsapirone increase growth hormone but not oxytocin secretion in normal male and female subjects

Abstract: The effects of gender and age on the degree of stimulation of GH secretion by 5-HT1A agonists in human subjects differ from their effects on secretion of the hormones ACTH and cortisol. A higher dose of ipsapirone is required to stimulate oxytocin secretion in normal human subjects.

Cited by 8 publications

References 20 publications

Hormonal and temperature responses to the 5-HT 1A receptor agonist flesinoxan in normal volunteers

Hormonal and temperature responses to the 5-HT 1A receptor agonist flesinoxan in normal volunteers

Serotonin-1A autoreceptor binding in the dorsal raphe nucleus of depressed suicides

Tickling of rats is associated with positive affective states, but does not replicate juvenile social play regarding the involvement of central oxytocin and vasopressin systems

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