Low educational status correlates with a high incidence of mortality among hypertensive subjects from Northeast Rural China

Yu, Shasha; Guo, Xiaofan; Li, Guangxiao; Yang, Hongmei; Zheng, Liqiang; Sun, Yingxian

doi:10.3389/fpubh.2022.951930

Cited by 2 publications

(2 citation statements)

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“…Both maternal and paternal education were associated with cardiometabolic outcomes, especially hypertension. In particular, evidence suggests that educational status might affect the development of adverse cardiometabolic health 106,107 . The majority of the studies show that a low level of maternal and paternal education is associated with a greater risk of hypertension during childhood 108,109 .…”

Section: Discussionmentioning

confidence: 99%

A systematic review of associations between risk factors during the first 1000 days of life and cardiometabolic outcomes later in childhood

Brandimonte-Hernández,

Ruiz-Ojeda,

Blaauwendraad

et al. 2024

Preprint

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ImportanceChildhood obesity increases cardiometabolic risk during childhood among individuals aged 2-18 years. These cardiometabolic outcomes include glucose intolerance, dyslipidemia, hypertension, metabolic syndrome, and type 2 diabetes (T2D). In the current state of research, a comprehensive review identifying all early-life exposures and risk factors that could predict cardiometabolic risk in children is lacking.ObjectiveTo identify and evaluate the predictive early-life risk factors during the first 1,000 days of life, including preconception, pregnancy and birth, and early infancy periods for cardiometabolic risk outcomes in childhood.Evidence reviewThe present systematic review of existing literature was conducted to revise and search selected electronic databases (Medline, EMBASE, WEB OF SCIENCE, SCOPUS, and Cochrane CENTRAL) for longitudinal studies published between the database’s inception and August17, 2022. This systematic review protocol was registered to PROSPERO, CRD42022355152, and following the PRISMA guidelines. We selected articles that studied the risk factors in mothers, fathers and infants, from preconception to infancy, for childhood cardiometabolic outcomes between 2 and 18 years.FindingsIn 68 studies, we identified 229 associations between exposures and childhood cardiometabolic outcomes namely glucose intolerance, dyslipidemia, hypertension, metabolic syndrome, and T2D. The majority of associations (n=162) were positively associated with cardiometabolic risk factors. Pregnancy and birth risk factors were the categories with the most reported associations (86%). Among them, the most frequently assessed characteristics were birth anthropometrics (n=75), sociodemographics data (n=47), and pregnancy complications factors (n=34). However, we only identified few risk factors during preconception. In infancy period, breastfeeding (n=16) and infant anthropometrics (n=15) were consistently associated with cardiometabolic outcomes. In all periods, the most studied associations were identified for hypertension and metabolic syndrome.Conclusions and relevanceBirth anthropometrics, sociodemographics, and pregnancy complication factors were the most frequently reported predictive factors associated with a higher risk for cardiometabolic outcomes in children, particularly hypertension and metabolic syndrome. These results of this study are useful for predicting the risk for childhood cardiometabolic outcomes and for the modifiable factors. They also may facilitate the design of approaches aimed at the alteration of several behaviours from birth to infancy, encompassing both the maternal and paternal influences, as well as the preconception to infancy transition period. Future studies evaluating early-life risk factors with scarce scientific evidence, such as paternal and preconception factors, are urgently needed.Key pointsQuestionWhat is the existing evidence of early-life risk factors during the first 1000 days of life that are associated with cardiometabolic dysfunction between 2 and 18 years?FindingsBirth anthropometrics, pregnancy complications, sociodemographics and lifestyle factors are the most frequently reported associated exposures with hypertension and metabolic syndrome in children.MeaningIdentifying early-life risk factors and changing behavior patterns throughout preconception and infancy can contribute to prevent metabolic diseases later in childhood.

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Section: Discussionmentioning

confidence: 99%

A systematic review of associations between risk factors during the first 1000 days of life and cardiometabolic outcomes later in childhood

Brandimonte-Hernández,

Ruiz-Ojeda,

Blaauwendraad

et al. 2024

Preprint

View full text Add to dashboard Cite

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“…Recent evidence accentuates the signi cant in uence of socioeconomic factors such as place of residence and household income on individuals' chronic conditions [31,32], HRQoL [33], and lifestyle choices [34]. Notably, individuals residing in China's rural areas with lower household incomes may experience a higher prevalence of NCDs [35], a lower level of HRQoL [36,37], and distinct lifestyles [37] due to socioeconomic disadvantages.…”

Section: Introductionmentioning

confidence: 99%

The relationship between the number of chronic diseases and health-related quality of life among middle-aged and older adults in rural areas of Yunnan province, China: moderating effect of health lifestyle

Chen,

Xiao,

Yan

et al. 2023

Preprint

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Background Individuals residing in underdeveloped rural settings may have a higher prevalence of chronic non-communicable diseases (NCDs), lower level of health-related quality of life (HRQoL), and distinct lifestyles. However, this triadic association remains inadequately studied and understood, particularly regarding the role played by health lifestyle. Yunnan province, as a typical underdeveloped region in China, is also witnessing population aging, with NCDs emerging as primary factors influencing both health status and HRQoL among middle-aged and older adults. This study aims to examine the relationship between the number of NCDs and HRQoL while exploring the potential moderating effect of health lifestyle among middle-aged and older adults residing in resource-limited areas. Methods This cross-sectional study was conducted in Yunnan province from July to December 2022. Spearman’s correlation test and Pearson’s correlation test were employed to examine the pairwise correlations among the number of NCDs, HRQoL, and health lifestyle. Hierarchical linear regression analysis was performed to explore the relationship between the number of NCDs and HRQoL, as well as investigate the potential moderating effect of health lifestyle on this relationship. Results Out of the total 2,704 participants, 57.91% presented with at least one NCD. The mean score for health lifestyle and health utility value were calculated as 11.109 and 0.944 respectively. A significant negative association was observed between the number of NCDs and health utility value, while a positive correlation was found between the number of NCDs and health lifestyle score. Health lifestyle exerted a moderating effect on the relationship between the number of NCDs and HRQoL (β = 0.006, P < 0.001), which was also observed for specific health-related behaviors such as sleep duration (β = 0.013, P < 0.001), physical examination attendance (β = 0.006, P < 0.05) and physical activity (β = 0.013, P < 0.001). Conclusions The study highlights that a healthy lifestyle exerts a crucial role in moderating the association between the number of NCDs and HRQoL. Considering the high prevalence of NCDs and substantial decline in HRQoL among middle-aged and older adults, recognizing the potential influence of a healthy lifestyle as a moderator in this relationship could be pivotal for developing effective interventions for this population, even within resource-constrained rural settings.

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Low educational status correlates with a high incidence of mortality among hypertensive subjects from Northeast Rural China

Cited by 2 publications

References 59 publications

A systematic review of associations between risk factors during the first 1000 days of life and cardiometabolic outcomes later in childhood

A systematic review of associations between risk factors during the first 1000 days of life and cardiometabolic outcomes later in childhood

The relationship between the number of chronic diseases and health-related quality of life among middle-aged and older adults in rural areas of Yunnan province, China: moderating effect of health lifestyle

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