Low Efficacy of Single-Dose Albendazole and Mebendazole against Hookworm and Effect on Concomitant Helminth Infection in Lao PDR

Soukhathammavong, Phonepasong Ayé; Sayasone, Somphou; Phongluxa, Khampheng; Xayaseng, Vilavanh; Utzinger, Jürg; Vounatsou, Penelope; Hatz, Christoph; Akkhavong, Kongsap; Keiser, Jennifer; Odermatt, Peter

doi:10.1371/journal.pntd.0001417

Cited by 132 publications

(128 citation statements)

References 30 publications

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“…4,5 The Cambodian Ministry of Health recommends that pregnant women receive one dose of deworming treatment (mebendazole) after the first trimester 6 ; however, the benefit of this one dose (if taken) is in question as its efficacy appears low, with a cure (egg-negative after treatment) rate of only ∼18-36% for helminth infections in school-aged children in neighboring Lao People's Democratic Republic. 7 We acknowledge that the effectiveness of deworming treatments also largely depends on the types of parasitic infections present. Therefore, Cambodian women are vulnerable to helminth infections early and throughout pregnancy, with higher risks for women who do not seek prenatal care at health centers.…”

Section: Introductionmentioning

confidence: 99%

Improved Sanitation Facilities are Associated with Higher Body Mass Index and Higher Hemoglobin Concentration Among Rural Cambodian Women in the First Trimester of Pregnancy

Janmohamed

Karakochuk

McLean

et al. 2016

The American Society of Tropical Medicine and Hygiene

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Abstract. Multiple factors contribute to undernutrition in Cambodian women. Our aim was to determine if type of household sanitation facility was associated with body mass index (BMI) and hemoglobin (Hb) concentration among pregnant women. Women (N = 544) from 75 villages in Kampong Chhnang Province had their height, weight, and Hb measured (HemoCue Hb 201 + ) in the first trimester. Sociodemographic and household characteristics were collected. Multivariable linear and logistic regression models were used for analyses. Approximately 40% (N = 221) of women reported primarily using an 'improved' sanitation facility (closed pit latrine) and ∼60% (N = 323) used 'non-improved' facilities (open defecation). Mean ± standard deviation (SD) BMI was higher among women with improved versus non-improved facilities (19.9 ± 3.0 kg/m 2 versus 19.4 ± 2.3 kg/m 2 ; P = 0.01). Mean ± SD Hb concentration was also higher among women with improved versus non-improved facilities (118 ± 12 g/L versus 114 ± 14 g/L; P = 0.001). Anemia prevalence (Hb < 110 g/L) was higher among women with non-improved facilities (34% versus 25%; P = 0.04). An improved sanitation facility was a positive predictor of BMI (β = 0.57 kg/m 2 ; 95% confidence interval [CI] = 0.10, 1.04) and Hb concentration (β = 2.94 g/L; 95% CI = 0.53, 5.35), adjusting for age, parity, household size, village, gestation week, source of drinking water, and iron folic acid supplementation. Poor sanitation was associated with lower BMI and Hb concentration among pregnant Cambodian women. This warrants multisectoral approaches involving the health, nutrition, water, and sanitation sectors to effectively improve maternal health in Cambodia.

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Section: Introductionmentioning

confidence: 99%

Improved Sanitation Facilities are Associated with Higher Body Mass Index and Higher Hemoglobin Concentration Among Rural Cambodian Women in the First Trimester of Pregnancy

Janmohamed

Karakochuk

McLean

et al. 2016

The American Society of Tropical Medicine and Hygiene

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“…Similar results were also obtained by Jozef Vercruysse et al (2011) 14 who while evaluating CR of albendazole for STHs, carried out seven trials among school children in Brazil, Cameroon, Cambodia, Ethiopia, India, Tanzania and Vietnam and achieved a CR of 98.2% for A. lumbricoides, followed by hookworm (87.8%) and T. trichiura (46.6%). However, Soukhathammavong et al (2012) 15 in a trial to assess the efficacy of single-dose of albendazole and mebendazole against hookworm in school children in Lao PDR obtained a disappointingly low CR of 36.0% and 17.6% respectively. In a similar study to assess efficacy of ALB using triple dose therapy, Yap et al (2013) 16 in a study of school-age children in Fig.…”

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confidence: 99%

A study of prevalence of intestinal worm infestation and efficacy of anthelminthic drugs

Kumar¹,

Jain²,

Jain

2014

Medical Journal Armed Forces India

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“…Strategy of selecting albendazole in mass treatment was appropriate and suitably chosen where most of prevalent parasites found in the study area as E. vermicularis were eradicated or greatly decreased as with the common intestinal protozoa as E. histolytica/dispar or G. intestinalis found among the treated children. Both albendazole and mebendazole showed high efficacies against entrobiasis and ascariasis, while the efficacy of albendazole against hookworm was relatively low, but still higher than that of mebendazole [25] , so it is recommended to use the former in areas endemic with hookworm infection.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of a deworming campaign by albendazole during 2016 in a rural area of Giza Governorate, Egypt

Dahesh

2018

Parasitologists United Journal

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Background: Egypt carried out the first national deworming campaign in 2016 targeting two million school-age children. The control program was led by the Endemic Diseases Department of the Egyptian Ministry of Health and Population (MOHP), in collaboration with the WHO Office in Egypt. Endemic Diseases Control Administration of Giza Governorate selected Tamwah village for the present work to represent the rural areas of Giza Governorate. The campaign targeted children from the first grade of primary schools aging around six years. In that campaign the children were treated with two doses of albendazole tablets 400 mg (two weeks apart). Objective: The present work aimed to evaluate the deworming campaign conducted during 2016 in one of the rural areas of Giza Governorate, Egypt and the efficacy of albendazole, the chosen treatment, in reducing parasitic infection rates among the targeted age group. The intention was to upgrade the results of the campaign by examining the same targeted group of children post treatment in comparison with a control group of untreated children from the same area thus widening the range of selected children. Also to collect environmental and epidemiological data for the study area of the examined children for constructing a new coordinative collaborative program suitable for controlling not only the soil transmitted parasites but also other endemic disease as schistosomiasis found in our study area. Subjects and methods: This cross-sectional study targeted two groups. The first group included all children of grade one in three primary schools who had received two doses of 400 mg albendazole tablets, two weeks apart. The second group (control group) included children of grade two who had not received medication. Stool specimens and anal swabs were collected from both treated and untreated control groups two weeks after receiving the second dose of treatment for the treated group. Personal and environmental data were recorded. The stool samples were examined by direct wet smear and kato-katz technique. The anal swabs were examined by saline swab method recommended for detection of Enterobius vermicularis ova. The data were tabulated and statistically analyzed. Results: E. vermicularis was the most prevalent parasite among the untreated group followed by E. histolytica/dispar, G. intestinalis and H. nana. Parasite rate of E. vermicularis among untreated females was twice that among males. The difference was statistically significant. Mass treatment with albendazole, resulted in significant differences between the parasite rates among the untreated and treated groups regarding E. vermicularis, E. histolytica/dispar and G. intestinalis. Treatment had no effect on parasite rate of H. nana. Generally the infection rates whether single or mixed, were significantly higher among untreated children than treated ones. Conclusion: The strategy of selecting albendazole for mass treatment in such areas proved appropriate, and suitably chosen since most of the prevalent parasites encountered ...

show abstract

Low Efficacy of Single-Dose Albendazole and Mebendazole against Hookworm and Effect on Concomitant Helminth Infection in Lao PDR

Cited by 132 publications

References 30 publications

Improved Sanitation Facilities are Associated with Higher Body Mass Index and Higher Hemoglobin Concentration Among Rural Cambodian Women in the First Trimester of Pregnancy

Improved Sanitation Facilities are Associated with Higher Body Mass Index and Higher Hemoglobin Concentration Among Rural Cambodian Women in the First Trimester of Pregnancy

A study of prevalence of intestinal worm infestation and efficacy of anthelminthic drugs

Evaluation of a deworming campaign by albendazole during 2016 in a rural area of Giza Governorate, Egypt

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