Low Energy Laser Irradiation Prevents the Early Morphological and Electrophysiological Effects of Optic Nerve Injury

Rosner, Mordechai; Belkin, Michael; Erlich, M. Shala; Friedman, Joachim; Schwartz, Michal

doi:10.1007/978-3-642-72870-9_175

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…20 . However, this effect was temporary and eventual degeneration always occurred, even when the irradiations were continued 1 .…”

Section: Discussionmentioning

confidence: 99%

Low Power Laser Irradiation Effect with Emphasis on Injured Neural Tissues.

Schwartz¹

1993

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“…20 . However, this effect was temporary and eventual degeneration always occurred, even when the irradiations were continued 1 .…”

Section: Discussionmentioning

confidence: 99%

Low Power Laser Irradiation Effect with Emphasis on Injured Neural Tissues.

Schwartz¹

1993

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“…These effects were accompanied by diminution of the extent of scar tissue normally observed at the site of the injury [7,121. Furthermore, the irradiation of crushed optic nerves of rats for 2 weeks resulted in higher compound action potential (CAP) compared to the injured nonirradiated nerves [6,11]. However, this effect was temporary and was achieved only when the irradiations began shortly after the injury.…”

Section: Introductionmentioning

confidence: 99%

Dose and temporal parameters in delaying injured optic nerve degeneration by low‐energy laser irradiation

et al. 1993

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Low-energy laser irradiation has been reported to postpone the degenerative processes in crushed optic nerves of rats, which are part of the nonregenerable mammalian central nervous system. In the present study, we evaluated the optimal irradiation parameters for this purpose. Optic nerves of 141 rats were subjected to crush injury and then irradiated through the eye, starting at different points of time before or after the injury, for different durations and periods, using various intensities of either helium-neon laser or noncoherent infrared light (904 nm). The effect was evaluated by measurements of the compound action potentials of the nerve segments between the site of injury and the optic chiasm. The compound action potential amplitude of the crushed nonirradiated nerves, as measured 2 weeks after the injury, was found to be 0.51 +/- 0.30 mV, in contrast to 3.10 +/- 1.03 mV measured in 232 normal nerves. Irradiation with a 10.5 mW helium-neon laser for 2 and 3 min once a day for 14 consecutive days resulted in maximal preservation of action potentials (1.78 +/- 0.72 and 1.95 +/- 0.71 mV, respectively). Irradiations beginning immediately prior to the injury were as effective as irradiations beginning soon after it. Irradiations for longer than 3 min or twice a day aggravated the damage. Noncoherent infrared light was ineffective or adversely affected the injured nerves. Our experiments suggest that optimal delay of posttraumatic optic nerve degeneration in rats is attainable with 10.5 mW helium-neon laser irradiations for 2 or 3 min once a day for 14 consecutive days.

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Does low‐Intensity helium‐Neon laser irradiation alter sensory nerve active potentials or distal latencies?

et al. 1990

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The effect of 1 mW helium neon continuous-wave (0.633 microns) laser irradiation on superficial radical sensory and median sensory nerve function was examined in a double-blind, controlled study involving 40 volunteers. No differences in action potential amplitudes, distal latencies, or forearm skin temperatures were found between the treated and control groups either at the time of irradiation or at subsequent evaluations 15 and 30 minutes later. As a result, we are unable to confirm reports that low-energy lasers of this power and wavelength alter nerve function.

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Low Energy Laser Irradiation Prevents the Early Morphological and Electrophysiological Effects of Optic Nerve Injury

Cited by 3 publications

References 7 publications

Low Power Laser Irradiation Effect with Emphasis on Injured Neural Tissues.

Low Power Laser Irradiation Effect with Emphasis on Injured Neural Tissues.

Dose and temporal parameters in delaying injured optic nerve degeneration by low‐energy laser irradiation

Does low‐Intensity helium‐Neon laser irradiation alter sensory nerve active potentials or distal latencies?

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