Low‐energy laser stimulates tooth movement velocity via expression of RANK and RANKL

Fujita, Shoji; Yamaguchi, Masaru; Utsunomiya, Tohru; Yamamoto, Hiroshi; Kasai, Kazuhiko

doi:10.1111/j.1601-6343.2008.00423.x

Cited by 186 publications

(167 citation statements)

References 39 publications

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“…These effects are due to its ability to stimulate cell metabolism, angiogenesis, bone formation and osteoclastogenesis (Garnero et al, 1994;Fassbender et al, 2009;Fujita et al, 2008.;Fujiyama et al, 2008;Habib et al, 2012;Genc et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Effect of Low Level Laser Therapy on Local Bone Resorption During Orthodontic Treatment: A Randomized Controlled Trial

Domínguez

León

Aristizabal

2016

Int. J. Odontostomat.

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DOMINGUEZ, Á.; LEÓN, P.; ARISTIZABAL. J. F. Effect of low level laser therapy on local bone resorption during orthodontic treatment. A randomized controlled trial. Int. J. Odontostomat., 10(3):483-490, 2016. ABSTRACT:The aim of this study was to assess whether the application of low-level laser therapy (LLLT) during the first stage of orthodontic treatment has an effect on local bone resorption and is detectable at the systemic level by measuring deoxypyridinoline levels (Pyrilinks) in urine. This was a randomized (1:1), double-blind, active-controlled, parallel-group trial. 28 adult patients who were going to start orthodontic treatment were randomly divided into the control group (n: 13) and the experimental group (n: 15), the latter of which received LLLT. All of the subjects underwent testing of urine samples: the first one on the day before the beginning of orthodontic treatment (T0), and the second one 5 days after bracket placement to measure Pyrilinks values (Dpd/Cr) in urine. Group differences were evaluated with Student's paired t-test. At the beginning of the study, the Pyrilinks were in the normal range for 53.57 % of the patients, and 46.43 % had elevated values according to the normal ranges. Only taking into account the normal values at (T0), the average Pyrilinks for control group (T0) were 5.75± 1.20 nM/mM, (T1): 6.02±3.00 nM/mM. For experimental group, (T0) was 5.71± 0.72, and it was 6.63± 0.73 in (T1).There were no significant differences in the Pyrilinks changes. (p= 0.75). In the experimental group levels raised statistically significant (p = 0.009). LLLT on patients starting orthodontic treatment with normal Pyrilinks levels have a statistically significant increment on their levels 5 days post irradiation.

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Section: Introductionmentioning

confidence: 99%

Effect of Low Level Laser Therapy on Local Bone Resorption During Orthodontic Treatment: A Randomized Controlled Trial

Domínguez

León

Aristizabal

2016

Int. J. Odontostomat.

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“…This process results in beneficial therapeutic outcomes including but not limited to the alleviation of pain or inflammation, immunomodulation, and promotion of wound healing and tissue regeneration.^ [1]. PBM therapy was found to have multiple clinical benefits, which includes reducing pain [2][3][4][5][6][7], improving wound healing [8][9][10][11], accelerating bone healing [12][13][14][15][16][17], promoting osteointegration [18], facilitating orthodontic tooth movement [19][20][21][22][23][24][25][26], stimulating bone formation [27][28][29][30][31], and improving periodontal tissue repair and decreasing inflammation and root resorption [23,26,32]. The light sources were laser or a light-emitting diode (LED).…”

Section: Introductionmentioning

confidence: 99%

“…Fujita et al [20] found that PBM with LED does not stimulate tooth movement while PBM with laser does. Elke et al [33] reported significantly different fibroblast proliferations when applying PBM with different wavelengths.…”

Section: Introductionmentioning

confidence: 99%

Light transmittance of the periodontium

et al. 2017

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Objective Photobiomodulation (PBM) therapy stimulates cells and regulates their activities. However, the actual accumulated dose that the cells receive is still unknown because the transmittances of the light on various tissues are not available. The objective of this study is to determine the light transmittances of the oral tissues. Methods Tissue samples of gum, cortical bone, and trabecular bone were prepared from ten Yucatan pigs' mandibles. Both the transmittance and the attenuation coefficient in the Beer-Lambert law were used to characterize the materials' light transmittance behavior. A higher attenuation coefficient indicates lower transmittance. The samples were tested with the light within the wavelength ranging from 420 to 1050 nm. The light intensity measured with and without the samples was used to calculate the transmittance. Results The result showed that the Beer-Lambert law can be used to estimate the transmittance if the light surface loss is eliminated. Among the three tissues, the gum has the highest attenuation coefficient and the trabecular bone has the lowest. The attenuation coefficient is higher at lower wavelengths for all three tissues, and is lower and keeps plateaued at the wavelength from 700 to 1050 nm. The surface loss rate of gum is higher at lower wavelengths. The light intensity within the tested range does not affect the transmittance.

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“…22 Although most of the protocols used for applying LLL during OTM are punctual, there are variations in the wavelengths, doses and the number of irradiation sessions. Some authors have used daily irradiations of LLL, 4,11,15 while others have set different intervals of laser application. 2,13,22 Considering that the effect of laser is dose-dependent, 6,10 greater attention should be given to the irradiation protocols.…”

mentioning

confidence: 99%

“…18 Furthermore, studies that observed an increase in OTM with daily laser irradiation have demonstrated that the rate of OTM rises between the second and third days, keeping a constant difference between groups after this period. 4,11 Thus, it is necessary to test protocols for LLL application which include irradiation only in the initial stage of OTM.…”

mentioning

confidence: 99%

Evaluation of two protocols for low-level laser application in patients submitted to orthodontic treatment

Marquezan¹,

Bolognese

Araújo

2013

Dental Press J. Orthod.

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Introduction:Different low-level laser (LLL) irradiation protocols have been tested to accelerate orthodontic tooth movement (OTM). Nevertheless, divergent results have been obtained. It was suggested that the stimulatory action of low level laser irradiation occurs during the proliferation and differentiation stages of bone cellular precursors, but not during later stages. Objective: The purpose of this study was to determine the effect of two protocols of LLL irradiation on experimental tooth movement: One with daily irradiations and another with irradiations during the early stages. Methods: Thirty-six rats were divided into control groups (CG1, CG2, CG3) and irradiated groups (IrG1, IrG2, IrG3) according to the presence of: experimental tooth movement, laser irradiation, type of laser irradiation protocol and date of euthanasia (3th or 8th day of experiment). At the end of experimental periods, a quantitative evaluation of the amount of OTM was made and the reactions of the periodontium were analyzed by describing cellular and tissue reactions and by counting blood vessels. Results: The amount of OTM revealed no significant differences between groups in the same experimental period (p < 0.05). Qualitative analysis revealed the strongest resorption activity in irradiated groups after seven days, especially when using the daily irradiation protocol. There was a higher number of blood vessels in irradiated animals than in animals without orthodontic devices and without laser irradiation (p < 0.05). Conclusion: Moreover, angiogenesis was verified in some of the irradiated groups. The irradiation protocols tested were not able to accelerate OTM and root resorption was observed while they were applied. Keywords: Lasers. Low-level laser therapy. Tooth movement. Angiogenesis inducing agents. Introdução: diferentes protocolos de irradiação por laser de baixa potência (LBP) têm sido testados para potencializar o movimento ortodôntico; entretanto, há resultados divergentes. Foi sugerido que seu efeito bioestimulador ocorre nas fases de proliferação e diferenciação celular, não agindo em estágios tardios. Objetivo: avaliar o efeito de dois protocolos de irradiação do LBP na movimentação ortodôntica: um com irradiações diárias e outro em que irradiações foram realizadas apenas nos períodos iniciais. Métodos: trinta e seis ratos Wistar foram divididos em grupos controles (GC1, GC2 e GC3) e irradiados (GIr1, GIr2 e GIr3), de acordo com a presença de dispositivo ortodôntico, a presença de irradiação, o tipo de protocolo de irradiação e a data de eutanásia (3º ou 8º dia de experimento). Ao final dos períodos experimentais, foram realizadas mensurações da movimentação dentária, análise qualitativa das reações celulares e teciduais do periodonto e contagem de vasos sanguíneos no ligamento periodontal. Resultados: a quantidade de movimentação não diferiu entre os grupos num mesmo tempo experimental (p < 0,05). A análise qualitativa revelou maior atividade absortiva nos grupos irradiados ao final de 7 dias, especialmente quand...

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Low‐energy laser stimulates tooth movement velocity via expression of RANK and RANKL

Abstract: These findings suggest that low-energy laser irradiation stimulates the velocity of tooth movement via induction of RANK and RANKL.

Cited by 186 publications

References 39 publications

Effect of Low Level Laser Therapy on Local Bone Resorption During Orthodontic Treatment: A Randomized Controlled Trial

Effect of Low Level Laser Therapy on Local Bone Resorption During Orthodontic Treatment: A Randomized Controlled Trial

Light transmittance of the periodontium

Evaluation of two protocols for low-level laser application in patients submitted to orthodontic treatment

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