Low-exposure cadmium is more toxic on osteoporotic rat femoral bone: Mechanical, biochemical, and histopathological evaluation

Çömelekoğlu, Ülkü; Yalın, Serap; Bagis, Selda; Őğenler, Oya; Şahin, Nefise Özlen; Yıldız, Altan; Coşkun, Banu Demet Özel; Hatungil, Rezan; Turac, Aysegul

doi:10.1016/j.ecoenv.2006.01.006

Cited by 35 publications

(22 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In other study in 2007, on rats biochemical factors and, the rate of alkaline phosphatase enzyme activity has increased in comparison with control group. These results were in accordance with longterm doses 1, 2 mg/kg cadmium that enhance the alkaline phosphatase activity [19]. Enhancing the function of alkaline phosphatase in high doses cadmium maybe due to cadmium which impairs the bone tissue and this enzyme exists in osteoblustoma cells and it is necessary for bonemaking and has increased in blood circulation [20].…”

Section: Discussionsupporting

confidence: 69%

“…In a study (2007) on the rats biochemical factors which were exposed to different doses of cadmium, showed that in comparison with the control group, the rate of calcium has increased. This study is in conformity with the long term results of the present project [19]. Enhancing calcium plasma concentration or hypocalcaemia is occurred mostlyin skeleton disease such as bone carcinoma, osteoporosis, and,etc.…”

Section: Discussionsupporting

confidence: 64%

See 1 more Smart Citation

Protective Effects of Long Term Administration of Zinc on Bone Metabolism Parameters in Male Wistar Rats Treated with Cadmium

Najafi

Moshtaghie

Noori

2016

Zahedan J Res Med Sci

View full text Add to dashboard Cite

Background: Violent poisoning by cadmium in human is created through drinks or meals which have packed in the metallic tins with cadmium plating. The symptoms of variation in the mineral metabolism of bones are observed and different conditions maybe appeared. The toxic (poisonous) effect due to cadmium can be neutralized by intervening zinc. This study has been designed to investigate the protective effects of zinc for reducing the poisonous effects due to cadmium on the metabolism in the parameters related to the bone in rat.

show abstract

Section: Discussionsupporting

confidence: 69%

Section: Discussionsupporting

confidence: 64%

Protective Effects of Long Term Administration of Zinc on Bone Metabolism Parameters in Male Wistar Rats Treated with Cadmium

Najafi

Moshtaghie

Noori

2016

Zahedan J Res Med Sci

View full text Add to dashboard Cite

show abstract

“…Another study by the same researchers revealed that exposure to 1 mg/l Cd did not affect the mechanical properties of the bone, but exposure to 50 mg/l Cd markedly reduced mechanical properties such as bone resistance, displacement at yield and bone stiffness in male rats (Brzoska and Monioszko-Jakoniuk, 2005). However, Comelekoglu et al (2007) noted that femur resistance was not affected by 0.5 mg/kg BW injections into rats. Moreover, Brzoska et al (2010) indicated that low chronic exposure to Cd (1 mg/l) did not have an effect on bone resistance to fracture, whereas moderate (5 mg/l) or relatively high (50 mg/l) exposure Effect of cadmium in laying quails seriously increased the risk of fracture of the long bones in males.…”

Section: Discussionmentioning

confidence: 96%

“…The addition of Cd to the diet decreased the shear stress of the tibia linearly. Comelekoglu et al (2007) showed that injection of 0.5 mg Cd/kg BW in rats had no effect on the stress of the femur. The addition of Cd to the diets decreased the boron content of the eggshells linearly.…”

Section: Discussionmentioning

confidence: 97%

The effect of dietary cadmium supplementation on performance, egg quality, tibia biomechanical properties and eggshell and bone mineralisation in laying quails

Olgun

2015

Animal

View full text Add to dashboard Cite

The aim of this study was to investigate the effects of different levels of cadmium supplementation (0, 5, 10, 20, 40 and 80 mg/kg) in the diet on performance, egg quality, tibia biomechanical properties and eggshell and bone mineral contents in laying quails. In this 10-week trial, a total of 96 laying quails, aged 21 weeks, were randomly distributed among six experimental groups. Each experimental group contained four replicates of four birds each. The performance parameters were adversely affected quadratically when cadmium was added to the diets in the concentrations of 20 mg/kg and above ( P < 0.01). The specific gravity and eggshell weight were maximal with the addition of 20 mg/kg cadmium to the diet. The biomechanical properties of the tibia were negatively affected by cadmium supplementation in quails ( P < 0.05). The eggshell boron content decreased linearly ( P < 0.001) with cadmium supplementation to the diet. The cadmium content in bone increased when cadmium was added to the diets ( P < 0.001). The bone boron concentration decreased as dietary cadmium supplementation was increased ( P < 0.001).Keywords: cadmium, bone, eggshell, performance, quail Implications Cadmium (Cd) is known as a toxic element for living organisms. However, low levels of Cd added to rations are also reported to have positive effects. In the present study, high levels of added Cd were toxic; however, when added in small amounts, positive effects were observed. There was a negative correlation between Cd and boron concentration in bones. IntroductionNumerous reports have shown that exposure to cadmium (Cd), which is very toxic and non-essential for poultry, results in limitations on growth, increased mortality and decreased egg production (EP) and eggshell quality (Leach et al., 1979;Nolan and Brown, 2000;Sant'Ana et al., 2005;Rahman et al., 2007). Leach et al. (1979) indicated that the addition of Cd (48 mg/kg) to the diets of laying hen markedly decreased EP and eggshell thickness during a 48-week trial period. Similarly, Rahman et al. (2007) showed that exposure to Cd (0.1 to 10 mg/kg BW injection) decreased EP and eggshell thickness in quails.Bones not only provide structural support for birds but are also an important mineral source for metabolic requirements such as for the formation of the eggshell in female birds. Cd has adverse effects on minerals such as calcium (Ca), which is the main component of bones and the eggshell. It has been reported that exposure to Cd decreased bone resistance and mineral levels in bones in rats (Brzoska and MoniuszkoJakoniuk, 2004;.Cd is known to be toxic for humans and animals (Friberg et al., 1992;Jarup, 2002;Satarug et al., 2003;Jemai et al., 2007), but the results of some studies indicate that it may be useful when low levels are added to diets (Leach et al., 1979;Bokori and Fekete, 1995;Pribilincova and Marettova, 1996;Rahman et al., 2007). Leach et al. (1979) reported a positive effect of Cd supplementation (3 mg/kg) on EP during a 12-week study in laying hens. Pribilincova and Mar...

show abstract

“…Generally, biomechanical integrity of bone is one of the most important factors related to bone strength and tendency to fracture (Comelekoglu et al 2007). Presence of the osteoporotic structures in these rats can be explained by the direct and indirect mechanisms of Cd, DZN and Se toxic actions on bone tissue.…”

Section: Discussionmentioning

confidence: 99%

Acute and subchronic co-administrations to cadmium, diazinon and selenium induce apparent osteoporotic symptoms in adult male rats

et al. 2014

View full text Add to dashboard Cite

Cadmium (Cd) and diazinon (DZN) are known to be environmental risk factors for various bone diseases including osteoporosis. Selenium (Se), an essential constituent of many antioxidant enzymes, has in higher concentrations negative effects on the bone. The present study was aimed to investigate possible changes in femoral bone of adult male rats after their acute and subchronic exposures to Cd, DZN and Se. A total of 30 male Wistar rats were randomized into three experimental groups. The rats in the group A (4-months-old) were injected intraperitoneally with a mixture of 2 mg CdCl2 kg −1 , 20 mg DZN kg −1 and 2 mg Na2SeO3 kg −1 body weight and killed 36 h after xenobiotics had been injected. In the group B, young males (1-month-old) were administered with a combination of 30 mg CdCl2 L −1 , 40 mg DZN L −1 and 5 mg Na2SeO3 L −1 in their drinking water, for 90 days. Ten 4-months-old males without toxicant supplementation served as a control group (C). After treatment period, detailed histological analysis of femoral bone was performed in each group. Our results revealed apparent osteoporotic symptoms (resorption lacunae, osteoporotic fractures) in rats from groups A and B. Moreover, histomorphometrical evaluation showed reduced bone vascularization (constricted primary osteons' vascular canals and Haversian canals) and weakness mechanical properties of bones (smaller size of the secondary osteons) in these rats in comparison with those of the control group. Our study demonstrates for the first time that acute and subchronic co-administrations to Cd, DZN and Se induce evident manifestation characteristics of osteoporosis in male rats.

show abstract

Low-exposure cadmium is more toxic on osteoporotic rat femoral bone: Mechanical, biochemical, and histopathological evaluation

Cited by 35 publications

References 18 publications

Protective Effects of Long Term Administration of Zinc on Bone Metabolism Parameters in Male Wistar Rats Treated with Cadmium

Protective Effects of Long Term Administration of Zinc on Bone Metabolism Parameters in Male Wistar Rats Treated with Cadmium

The effect of dietary cadmium supplementation on performance, egg quality, tibia biomechanical properties and eggshell and bone mineralisation in laying quails

Acute and subchronic co-administrations to cadmium, diazinon and selenium induce apparent osteoporotic symptoms in adult male rats

Contact Info

Product

Resources

About