Low expression of chloride channel accessory 1 predicts a poor prognosis in colorectal cancer: The question is still open

Shahidsales, Soodabeh; Mobarhan, Majid Ghayour; Ghasemi, Faezeh; Gholamin, Sharareh; Avan, Amir

doi:10.1002/cncr.29598

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…Recently, there has been a focus on molecular markers for predicting prognoses in colorectal cancer (16,(19)(20)(21)(22)(23)(24).In the present study, we determined the expression of WLS protein and its association with clinicopathological parameters. Our results show that WLS protein is highly expressed in most colorectal cancer tissues compared with the adjacent noncancerous mucosa tissues.…”

Section: Discussionmentioning

confidence: 92%

“…Although various clinicopathological factors, including preoperative tumor markers and TNM factors, have been reported as prognostic factors, it is not easy to identify patients with high risk of recurrence. Recently, there has been a focus on molecular markers for predicting prognoses in colorectal cancer .In the present study, we determined the expression of WLS protein and its association with clinicopathological parameters. Our results show that WLS protein is highly expressed in most colorectal cancer tissues compared with the adjacent noncancerous mucosa tissues.…”

Section: Discussionmentioning

confidence: 95%

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Expression of Wntless in colorectal carcinomas is associated with invasion, metastasis, and poor survival

Jiang

Zhu

et al. 2016

APMIS

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Wntless also known as WLS, GPR177, or Evi, is a key modulator of Wnt protein secretion. Its overexpression is found in certain types of human cancers such as malignant astrocytoma and breast cancers. We hypothesized that this protein may be aberrantly expressed in colorectal carcinoma which also possesses aberrant Wnt signaling. To investigate the association between the expression of Wnt and clinicopathological parameters in colorectal carcinomas, a set of colorectal carcinoma tissue samples was analyzed for the expression of WLS using an anti-GPR177 monoclonal antibody specific for the WLS protein. High expression of WLS protein was observed in most colorectal carcinoma samples compared with nontumor mucosa in the same patients (117/201, 58.2%). High expression of WLS was associated with sex (p = 0.005), age (p = 0.009), depth of invasion (p < 0.001), lymph node metastasis (p = 0.026), and tumor-node-metastasis (TNM) stage (p = 0.003). No significant relationship between the expression of WLS and tumor location, size, and differentiation was found. The survival analyses showed WLS was an independent prognostic marker and that patients whose carcinoma exhibited high expression of WLS had a poorer outcome (p = 0.033). Our results indicate that WLS may play a role in invasion and metastasis of colorectal carcinoma. The WLS protein expression level may be used as a potential prognostic marker in colorectal carcinoma. Furthermore, the WLS gene may provide a novel target for therapy of colorectal carcinoma.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 95%

Expression of Wntless in colorectal carcinomas is associated with invasion, metastasis, and poor survival

Jiang

Zhu

et al. 2016

APMIS

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“…In second‐line treatment, targeted therapy is added to chemotherapy, to interrupt specific cellular mechanisms, or signaling pathways (Hosseini et al, ). For examples, in CRC, monoclonal antibodies to the epidermal growth factor (EGF) receptor may be used, as this is often involved in the proliferation of CC cells (ShahidSales, Mobarhan, Ghasemi, Gholamin, & Avan, ). Bevacizumab, aflibercept, and regorafenib are anti‐angiogenic drugs currently approved for the treatment of metastatic CRC (Table ).…”

Section: Introductionmentioning

confidence: 99%

Targeting the tumor microenvironment as a potential therapeutic approach in colorectal cancer: Rational and progress

Bahrami

Khazaei

Hassanian

et al. 2017

Journal Cellular Physiology

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Colorectal cancer (CC) is often diagnosed at a late stage when tumor metastasis may have already occurred. Current treatments are often ineffective in metastatic disease, and consequently late diagnosis is often associated with poor outcomes in CC. Alternative strategies are therefore urgently required. An interaction between epithelial cancer cells and their tissue microenvironment is a contributor to metastasis, and therefore recent studies are beginning to focus on the properties of the tumor microenvironment and the mechanism by which the metastatic cells exploit the tumor microenvironment for survival, immune evasion, and growth. We have reviewed the development of the combined therapeutic approaches that have focused on targeting the microenvironment of CC.

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Comprehensive bioinformatics analysis reveals CLCA1 and ZG16 as predictive biomarkers of malignant progression in colorectal cancer

Zhang,

Wang,

Wang

et al. 2024

Preprint

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Background Colorectal cancer (CRC) is one of the most common malignant tumors. CLCA1 and ZG16 are lowly expressed in CRC, and we wanted to investigate whether they could be prognostic biomarkers for the malignant progression of CRC. Methods 12,195 DEGs and 12,071 DEGs were identified through the GSE39582 dataset and TCGA dataset, and then 50 coexisting genes were selected for further analysis using Venn diagrams. These 50 DEGs were then subjected to GO and KEGG functional enrichment analyses, along with genome-wide GSEA. the first 5 core genes were identified and visualized using Cytoscape through the PPI network. Then the expression of ZG16 and CLCA1 in normal and tumor tissues were analyzed using GSE39582 and TCGA datasets, and correlation analysis, and survival analysis were performed. The expression of ZG16 and CLCA1 in CRC cells was verified by qRT-PCR, and cell proliferation, migration, and invasion abilities were detected by CCK-8, scratch assay, clone formation assay, and Transwell assay. Results The expression levels of ZG16 and CLCA1 were significantly lower in tissues from CRC patients than in normal tissues. Survival analysis showed that low expression of ZG16 and CLCA1 was associated with poor survival outcomes. Multifactorial analysis showed that low expression of ZG16 and CLCA1 was an independent risk factor affecting tumor prognosis. Cellular experiments showed that cell proliferation, migration, and invasion were inhibited after overexpression of ZG16 and CLCA1. Correlation analysis showed that ZG16 and CLCA1 expression levels were positively correlated and the correlation was statistically significant. GSEA enrichment analysis based on CLCA1-related genes and ZG16-related genes (FDR < 0.25, P < 0.05) revealed that the related genes of both genes were closely related to the GNRH SINALINGPATHWAYES pathway. Conclusion CLCA1 and ZG16, which are lowly expressed in CRC tissues, are associated with poor prognosis of CRC and may be one of the markers for diagnostic screening and prediction of prognostic outcome in CRC. Meanwhile, CLCA1 and ZG16 may also be new targets for tumor immunotherapy.

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Low expression of chloride channel accessory 1 predicts a poor prognosis in colorectal cancer: The question is still open

Cited by 3 publications

References 8 publications

Expression of Wntless in colorectal carcinomas is associated with invasion, metastasis, and poor survival

Expression of Wntless in colorectal carcinomas is associated with invasion, metastasis, and poor survival

Targeting the tumor microenvironment as a potential therapeutic approach in colorectal cancer: Rational and progress

Comprehensive bioinformatics analysis reveals CLCA1 and ZG16 as predictive biomarkers of malignant progression in colorectal cancer

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