Low Expression of Circular RNA hsa_circ_0078607 Predicts Poor Prognosis in High-Grade Serous Ovarian Cancer

Zhang, Nan; Yang, Zhiyou; Jin, Yong; Cheng, Shanshan; Yang, Jiani; Wang, Yu

doi:10.2147/cmar.s300738

Cited by 12 publications

(5 citation statements)

References 24 publications

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“…M 6 A plays an important role in numerous biological processes, which contributes to cancer development, cancer cell proliferation and cancer stem cell self-renewal ( 28 , 29 ). The expression profile and potential function of circRNAs in different cancers have been identified, including HGSOC ( 13 , 30 , 31 ). As a new epitranscriptomic marker, m 6 A is recognized as a reversible and dynamic RNA modification in eukaryotes.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of m6A-modified circRNAs in peritoneal metastasis of high grade serious carcinoma of ovary

Guo

Xu²,

Qiu³

et al. 2022

Front. Oncol.

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PurposeHigh-grade serous ovarian cancer (HGSOC) remains the most lethal female cancer due to metastasis. CircRNAs are recently identified to be modified by N6-methyladenosine (m6A) in many cells. However, the significance of m6A-modified circular RNAs (circRNAs) has not been elucidated in HGSOC peritoneal metastasis. Here, we aimed to investigate the participation and potential functions of m6A-modified circRNAs in HGSCO peritoneal metastasis.MethodsCancerous tissues were collected from the in situ and the peritoneal metastasis lesions of HGSCO patients. M6A-tagged circRNAs were identified by m6A-modified RNA immunoprecipitation sequencing (m6A-RIP-seq). Gene Ontology (GO) annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed to predict the potential functions of the m6A-modified circRNAs.ResultsFor the m6A-modified circRNAs, 259 were upregulated and 227 were downregulated in the peritoneal metastasis than in the situ lesions of HGSCO patients. For the m6A peaks, 1541 were upregulated and 1293 were downregulated in the peritoneal metastasis than in the in situ lesions of HGSCO patients. For the differential expressed circRNAs, 1911(19.6%) were upregulated and 2883(29.6%) were downregulated in the peritoneal metastasis than in the in situ lesions of HGSCO patients. The upregulated m6A-modified circRNAs were associated with the HIF-1 signaling. The downregulated m6A-modified circRNAs were associated with the MAPK signaling.ConclusionsThis work firstly identified the transcriptome-wide map of m6A-modified circRNAs in peritoneal metastasis of HGSCO. Our findings provided novel evidences about the participation of m6A-modified circRNAs via HIF-1 and MAPK signaling and a new insight in molecular target of HGSCO peritoneal metastasis.

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Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of m6A-modified circRNAs in peritoneal metastasis of high grade serious carcinoma of ovary

Guo

Xu²,

Qiu³

et al. 2022

Front. Oncol.

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“…Circ_0078607 has been found to repress tumor progression via modulating the miR-518a-5p and Fas signaling pathway in ovarian cancer ( Zhang et al, 2020c ). Moreover, circ_0078607 expression was lower in high-grade serous ovarian cancer and associated with poor prognosis ( Zhang et al, 2021d ). Furthermore, circ_0078607 was reported to inhibit tumor progression via governing the miR-32-5p and SIK1 pathways in ovarian cancer ( Jin and Wang, 2022 ).…”

Section: Role Of Circrnas In Drug Resistancementioning

confidence: 99%

The role of circRNAs in regulation of drug resistance in ovarian cancer

Zhan,

Li,

Lin

et al. 2023

Front. Genet.

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Ovarian cancer is one of the female reproductive system tumors. Chemotherapy is used for advanced ovarian cancer patients; however, drug resistance is a pivotal cause of chemotherapeutic failure. Hence, it is critical to explore the molecular mechanisms of drug resistance of ovarian cancer cells and to ameliorate chemoresistance. Noncoding RNAs (ncRNAs) have been identified to critically participate in drug sensitivity in a variety of human cancers, including ovarian cancer. Among ncRNAs, circRNAs sponge miRNAs and prevent miRNAs from regulation of their target mRNAs. CircRNAs can interact with DNA or proteins to modulate gene expression. In this review, we briefly describe the biological functions of circRNAs in the development and progression of ovarian cancer. Moreover, we discuss the underneath regulatory molecular mechanisms of circRNAs on governing drug resistance in ovarian cancer. Furthermore, we mention the novel strategies to overcome drug resistance via targeting circRNAs in ovarian cancer. Due to that circRNAs play a key role in modulation of drug resistance in ovarian cancer, targeting circRNAs could be a novel approach for attenuation of chemoresistance in ovarian cancer.

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“…Moreover, circ_0078607 levels were reported to be decreased in HGSC tissues and were negatively correlated with the FIGO stage and serum CA125 levels. The subsequent Cox regression analysis showed that reduced circ_0078607 level was a risk factor for poor PFS and OS [ 109 ]. These findings suggest that high levels of circEXOC6B, circN4BP2L2, circITCH, and circ_0078607 are good prognostic markers for EOC patients.…”

Section: Circrnas As Potential Biomarkers In Eocmentioning

confidence: 99%

Circular RNAs in Epithelial Ovarian Cancer: From Biomarkers to Therapeutic Targets

Qiu

Chen

Agbede

et al. 2022

Cancers

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Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer, and more than 70% of patients are diagnosed at advanced stages. Despite the application of surgery and chemotherapy, the prognosis remains poor due to the high relapse rate. It is urgent to identify novel biomarkers and develop novel therapeutic strategies for EOC. Circular RNAs (circRNAs) are a class of noncoding RNAs generated from the “back-splicing” of precursor mRNA. CircRNAs exert their functions via several mechanisms, including acting as miRNA sponges, interacting with proteins, regulating transcription, and encoding functional proteins. Recent studies have identified many circRNAs that are dysregulated in EOC and may be used as diagnostic and prognostic markers. Increasing evidence has revealed that circRNAs play a critical role in ovarian cancer progression by regulating various cellular processes, including proliferation, apoptosis, metastasis, and chemosensitivity. The circRNA-based therapy may be a novel strategy that is worth exploring in the future. Here, we provide an overview of EOC and circRNA biogenesis and functions. We then discuss the dysregulations of circRNAs in EOC and the possibility of using them as diagnostic/prognostic markers. We also summarize the role of circRNAs in regulating ovarian cancer development and speculate their potential as therapeutic targets.

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Low Expression of Circular RNA hsa_circ_0078607 Predicts Poor Prognosis in High-Grade Serous Ovarian Cancer

Cited by 12 publications

References 24 publications

Comprehensive analysis of m6A-modified circRNAs in peritoneal metastasis of high grade serious carcinoma of ovary

Comprehensive analysis of m6A-modified circRNAs in peritoneal metastasis of high grade serious carcinoma of ovary

The role of circRNAs in regulation of drug resistance in ovarian cancer

Circular RNAs in Epithelial Ovarian Cancer: From Biomarkers to Therapeutic Targets

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