Low expression of MicroRNA‐126 is associated with poor prognosis in colorectal cancer

Liu, Yaling; Zhou, Yu; Xiao, Feng; Yang, Pengchun; Yang, Jingfang; An, Ping; Wang, Hao; Ye, Shicai; Yu, Caiyuan; Yang, He; Luo, Haitao

doi:10.1002/gcc.22146

Cited by 47 publications

(51 citation statements)

References 38 publications

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“…As shown in Figure 9A, CXCR4 over-expression was statistically associated with a poor OS (HR=1.94, 95% CI, 1.71-2.20) when including all 79 studies [9-34, 36, 37, 39-62, 64-69, 71, 72, 74-92] ; however, there was significant heterogeneity (I 2 =73%, p<0.01). Meta-influence analysis did not suggest undue influence of any single study.…”

Section: Resultsmentioning

confidence: 96%

CXCR4 over-expression and survival in cancer: A system review and meta-analysis

et al. 2014

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C-X-C chemokine receptor 4 (CXCR4) is frequently over-expressed in various types of cancer; many agents against CXCR4 are in clinical development currently despite variable data for the prognostic impact of CXCR4 expression. Here eighty-five studies with a total of 11,032 subjects were included to explore the association between CXCR4 and progression-free survival (PFS) or overall survival (OS) in subjects with cancer. Pooled analysis shows that CXCR4 over-expression is significantly associated with poorer PFS (HR 2.04; 95% CI, 1.72-2.42) and OS (HR=1.94; 95% CI, 1.71-2.20) irrespective of cancer types. Subgroup analysis indicates significant association between CXCR4 and shorter PFS in hematological malignancy, breast cancer, colorectal cancer, esophageal cancer, renal cancer, gynecologic cancer, pancreatic cancer and liver cancer; the prognostic effects remained consistent across age, risk of bias, levels of adjustment, median follow-up period, geographical area, detection methods, publication year and size of studies. CXCR4 over-expression predicts unfavorable OS in hematological malignancy, breast cancer, colorectal cancer, esophageal cancer, head and neck cancer, renal cancer, lung cancer, gynecologic cancer, liver cancer, prostate cancer and gallbladder cancer; these effects were independence of age, levels of adjustment, publication year, detection methods and follow-up period. In conclusion, CXCR4 over-expression is associated with poor prognosis in cancer.

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Section: Resultsmentioning

confidence: 96%

CXCR4 over-expression and survival in cancer: A system review and meta-analysis

et al. 2014

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“…Highly expressed in human endothelial cells, miR-126 is closely associated with several types of cancer and is possibly one of the future means for cancer treatment (4,20). Each tumor has its specific miRNA expression profiles, so miRNAs may be utilized for the early diagnosis of tumors and for predicting prognosis (21,22).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-126 enhances the sensitivity of osteosarcoma cells to cisplatin and methotrexate

Jiang

Cheng

2015

Oncology Letters

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Abstract. The establishment of novel chemotherapy drugs for osteosarcoma is urgently required, and the mechanisms and effects of cisplatin (DDP) and methotrexate (MTX) in the current treatment of osteosarcoma have not been fully elucidated. The present study aimed to observe the effect of DDP, MTX and rapamycin on osteosarcoma cell proliferation and apoptosis, and to investigate the association between miR-126 and the effects of DDP and MTX in osteosarcoma cells. miR-126-overexpressing and -silencing lentiviral vectors were constructed, and MG63 and U-2 OS osteosarcoma cells were infected. An MTT assay was conducted to detect transfected cell proliferation, and the effects of the chemotherapy drugs on transfected cell apoptosis were detected by flow cytometry. The cell cycle of the transfected cells was analyzed via flow cytometry. As the miR-126-overexpressing and -silencing osteosarcoma cell lines were successfully constructed, it was observed that DDP and MTX inhibited osteosarcoma cell proliferation. With the decreased expression of miR-126, the sensitivity of osteosarcoma cells to DDP and MTX was reduced at the same concentration. The flow cytometry suggested that DDP and MTX could promote the apoptosis of osteosarcoma cells with overexpressed miR-126, whereas they could not significantly impact the apoptosis of the miR-126-silenced osteosarcoma cells. Meanwhile, DDP inhibited the cell cycle of the miR-126-overexpressing osteosarcoma cells. In conclusion, DDP and MTX inhibited the proliferation and promoted the apoptosis of the osteosarcoma cells, and these processes were dependent upon the expression of miR-126.

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“…furthermore, increasing numbers of mirnas have been observed in various types of cancer and may be involved in modulating cancer cell behavior (8)(9)(10). Several aberrantly expressed mirnas have been proven to be associated with tumorigenesis, tumor progression and metastasis in crc, and taken as prognostic indicators for crc including mir-150 (11), mir-28-5p/-3p (12), mir-200 (13) and many others (14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

miR-494 is an independent prognostic factor and promotes cell migration and invasion in colorectal cancer by directly targeting PTEN

Sun

Chen

et al. 2014

International Journal of Oncology

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Abstract. accumulating evidence has shown that micrornas (mirnas) are involved in multiple processes in cancer development and progression. upregulation of miRNA-494 (miR-494) has been identified as an oncogenic mirna and is associated with poor prognosis in several types of human cancer. However, the specific function of miR-494 in colorectal cancer remains unclear. in this study we found that the expression of mir-494 in colorectal cancer tissues and cell lines was much higher than in normal control tissues and cells, respectively. in addition, upregulation of mir-494 more frequently occurred in tissue specimens with adverse clinical stage and the presence of distant metastasis. Moreover, multivariate survival analyses demonstrated that overexpression of mir-494 is an independent prognostic factor for both progression-free and overall survival. in addition mir-494 promoted invasion and migration in colorectal cancer cells, and mir-494 directly inhibited the phosphatase and tensin homolog deleted on chromosome 10 (Pten) expression by targeting its 3'-untranslated region (3'-utr). Moreover, Pten is down regulated and inversely correlated with mir-494 expression in tissues. Thus, for the first time, we provided convincing evidence that upregulation of mir-494 was associated with tumor aggressiveness and tumor metastasis and promoted cell migration and invasion by targeting PTEN gene in colorectal cancer, and mir-494 is an independent prognostic marker for colorectal cancer patients. Introductioncolorectal carcinoma (crc) is the third most frequently diagnosed malignancy and the third leading cause of death among cancer patients in the united States (1). Despite current therapeutic strategies combining adjuvant chemotherapy, surgery and sometimes radiotherapy, the prognosis of crc remains poor, since most crc patients have distant metastases at diagnosis or develop recurrent metastatic crc following surgical treatment. although recent developments in molecular biology have provided insight into the molecular mechanisms of crc, the fundamental molecular mechanisms underlying metastasis in crc have not been fully elucidated. therefore, it is essential to identify metastasis-associated molecules as effective drug targets and to enhance the understanding of the mechanisms underlying the metastasis of crc.Micrornas (mirnas) are small non-coding rnas (~22 nucleotides in length), transcribed from non-protein-coding genes or introns, which regulate gene expression through repressing translation and cleaving their mrnas by binding to complementary sites in their 3'-untranslated region (3'-utr) (2). mirnas regulated the expression of a wide variety of target genes, and aberrant expression mirnas cause them to function as tumor suppressors or oncogenes according to the role of their target genes (3,4). Particularly, mirnas can regulate various biological processes of tumor cells, including cell proliferation, differentiation, progres sion, apoptosis, proliferation, migration and invasion (5-7). furthermore, increasing number...

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Low expression of MicroRNA‐126 is associated with poor prognosis in colorectal cancer

Cited by 47 publications

References 38 publications

CXCR4 over-expression and survival in cancer: A system review and meta-analysis

CXCR4 over-expression and survival in cancer: A system review and meta-analysis

MicroRNA-126 enhances the sensitivity of osteosarcoma cells to cisplatin and methotrexate

miR-494 is an independent prognostic factor and promotes cell migration and invasion in colorectal cancer by directly targeting PTEN

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