Low expression of WW domain‐containing oxidoreductase associates with hepatocellular carcinoma aggressiveness and recurrence after curative resection

Abstract

WW domain‐containing oxidoreductase (WWOX), which has a protein‐interaction domain and is regarded to be a tumor suppressor, has been known to play an important role in anti‐angiogenesis and cancer progression. This study aimed to investigate prognostic values of WWOX expression in hepatocellular carcinoma (HCC) patients after hepatectomy. Additionally, we intended to formulate a valuable prognostic nomogram for HCCs. 182 HCC patients who underwent hepatectomy from January 2009 to January 2010 were enrolled in our study. qRT‐PCR, Western blot, and immunohistochemistry on tissue microarrays were then used to determine the expression levels of WWOX. An evaluation of the role of WWOX expression levels in the prognosis and outcome of patients was established. A decrease in the expression of WWOX was found when compared to adjacent tumor‐free tissues, which led to worse overall survival (OS) and recurrence‐free survival (RFS) and, therefore, was considered as an independent negative factor in the prognosis of HCC. Two nomograms, comprising WWOX, alpha‐fetoprotein (AFP), tumor size, and γ‐glutamyltransferase (γ‐GT), were constructed to obtain superior discriminatory abilities than conventional staging systems in terms of C‐index and clinical net benefit on decision curve analysis (DCA) for OS and RFS. Our data suggest that WWOX expression is strongly related to HCC post‐resection aggressiveness and recurrence. Additional advanced and accurate predictive model through the incorporation of WWOX into nomogram could help predict OS or RFS for HCC patients.

A 16‐mRNA signature optimizes recurrence‐free survival prediction of Stages II and III gastric cancer

“…Receiver operating characteristic (ROC) analysis was performed to detect the accuracy of the nomogram using the “pROC” package of R software. Besides, decision curve analysis was also used to detect the clinical utility and compare nomogram with the TNM staging system (Pu et al, 2017; Vickers & Elkin, 2006; Zhou et al, 2018).…”

Catalytic hydrogen atom transfer to alkenes: a roadmap for metal hydrides and radicals

“…95 The stability may be even lower in catalytic WF iron systems; a recent computational study on Fe-catalyzed alkene MHAT reactions suggested that the homolytic bond energy of the iron(III) complex (acac) 2 Fe-tBu is only 1.5 kcal mol À1 . 27 In contrast, amine-bis(phenolate) iron complexes, which can catalyze MHAT hydroamination 96,97 and hydrouorination 98 as well as radical polymerization that follows a related mechanism, 99 have been studied by EPR, UV-Vis and Mössbauer spectroscopy during polymerization, and these suggested the formation of a transient iron(III) alkyl complex with a high-spin electronic conguration (Fig. 7B).…”

Stable Fe(iii) phenoxyimines as selective and robust CO2/epoxide coupling catalysts

“…1 We have had a longstanding interest in iron-mediated catalysis thanks to its abundance, low cost, and low toxicity. 17,18 In particular, Fe 3+ compounds offer a user-friendly route into catalysis, due to their air-and moisture-stability which enables convenient synthesis and handling. Only a few examples of mono-or bi-metallic Fe(III) complexes have been reported as catalysts for CO 2 /epoxide couplings and in most cases high catalyst loadings were required to achieve good conversions.…”