Low Expression of ZNF154 is Related to Poor Prognosis in Gastric Cancer

He, Jinsong; Huang, Jing; Tang, Guo Qing; Wang, Pan; He, Ming; Wei, Shoujiang

doi:10.2147/cmar.s340053

Cited by 5 publications

(3 citation statements)

References 31 publications

(36 reference statements)

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“…PLEKHS1 has been reported as a biomarker for the diagnosis and prognosis of gastric cancer [ 36 ]. In addition, ZNF154 was found to be a tumor suppressor gene, and its low expression was associated with the poor prognosis of gastric cancer [ 37 ]. All these results indicated the potential value of ANKRD53 in gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

Integrative analysis indicates the potential values of ANKRD53 in stomach adenocarcinoma

Jin,

Lu,

Yang

et al. 2024

Discov Onc

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Background Ankyrin repeat domain 53 (ANKRD53) plays an important role in maintaining chromosome integrity and stability, and chromosome instability is associated with cancer. Through integrative analysis, this study investigates the potential value of ANKRD53 in stomach adenocarcinoma (STAD). Methods RNA-seq and scRNA-seq data were used for integrative analysis based on online databases. Expression of ANKRD53 was confirmed by RT-PCR after bioinformatic analysis. Kaplan–Meier and Cox regression analyses were performed to evaluate the prognostic value of ANKRD53 in STAD. Gene set enrichment analysis (GSEA) was performed to evaluate ANKRD53-related signaling pathways. In addition, the interaction of ANKRD53 with immunity was also investigated. Results RT-PCR in STAD cell lines confirmed that ANKRD53 was downregulated in STAD samples compared to normal samples in the online databases. As an independent predictive biomarker, ANKRD53 was combined with other clinicopathological parameters to create a prognostic nomogram. Using GSEA, ANKRD53 was found to be involved in five pathways, including the TGF-β signaling pathway. Further investigation revealed that ANKRD53 was associated with immune checkpoint molecules, immunological pathways, and immunotherapy, in addition to MSI, TMB and neoantigens. In addition, scRNA-seq data revealed that ANKRD53 is mainly expressed in CD8+ T and dendritic cells. Conclusions ANKRD53 is an important biomarker for STAD that deserves further attention.

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Section: Discussionmentioning

confidence: 99%

Integrative analysis indicates the potential values of ANKRD53 in stomach adenocarcinoma

Jin,

Lu,

Yang

et al. 2024

Discov Onc

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“…Other studies with hypopharynx cancers suggest that ZNF154 has tumour-suppressive action by inhibiting the Wnt/β-catenin signalling pathway activation and suppressing epithelial-mesenchymal transition [ 20 ]. And most recently, expression of ZNF154 in MGC-803 gastric cancer cells reduced cell proliferation, viability, migration and invasion, and enhanced cell apoptosis and arrested cell cycle in G2 phase [ 26 ]. This overexpression of ZNF154 was associated with an increase in the expression of B-cell lymphoma-2 (Bcl-2), matrix metalloproteinase 1 (MMP-1), hepatocyte growth factor (HGF), vascular endothelial growth factor-A/C (VEGF-A/C).…”

Section: Discussionmentioning

confidence: 99%

Kruppel-family zinc finger proteins as emerging epigenetic biomarkers in head and neck squamous cell carcinoma

Pearson,

Smith,

Sood

et al. 2023

Journal of Otolaryngology - Head & Neck Surgery

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Background Krüppel-type zinc finger protein genes located on chromosome 19q13 are aberrantly hypermethylated with high frequency in all anatomic sub-sites of head and neck cancers as well as other epithelial tumours resulting in decreased expression. Methods We examined prognostic significance of ZNF154 and ZNF132 expression and DNA methylation in independent patient cohort of about 500 head and neck cancer patients in the Cancer Genome Atlas (TCGA). We also overexpressed these genes in HEK-293 cells, as well as the oral cancer cell line UM-SCC-1. Results In 20 patients from the TCGA cohort of HNSCC patients where ZNF154 and ZNF132 DNA methylation and RNA expression could be compared in tumor and adjacent normal tissue, there was increased DNA methylation and decreased expression of both ZNF154 and ZNF132 in primary tumours. Low ZNF154 and low ZNF132 expression were associated with shorter overall survival in both head and neck squamous cell carcinoma (HNSCC) and lung adenocarcinoma (LUAC patients). While expression of these proteins in HEK-293 cells produced full-length protein, only truncated copies could be expressed in head and neck cancer cells (UM-SCC-1). The truncated version of ZNF154 protein increased doubling time and reduced cell migration in UM-SCC-1 cancer cells. Conclusions Both ZNF132 and ZNF154 represent novel clinically significant biomarkers in head and neck cancer with potential tumour suppressive properties. Future studies will address the underlying molecular mechanisms by which ZNF154 expression in HNSCC contributes to the control of cell growth and migration. Graphical abstract

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“…Increased survival rates in pancreatic cancer patients were associated with the silencing of ZNF154, which, in turn, led to increased levels of SLFN5. However, the precise mechanism between ZNF154 and SLFN5 still requires further clarification ( 44 ).…”

Section: Association Between Slfn 5 and Malignant Tumorsmentioning

confidence: 99%

Progress in investigating the relationship between Schlafen5 genes and malignant tumors

Tu,

Yuan,

Liu

et al. 2023

Front. Oncol.

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The Schlafen5(SLFN5)gene belongs to the third group of the Schlafen protein family. As a tumor suppressor gene, SLFN5 plays a pivotal role in inhibiting tumor growth, orchestrating cell cycle regulation, and modulating the extent of cancer cell infiltration and metastasis in various malignancies. However, the high expression of SLFN 5 in some tumors was positively correlated with lymph node metastasis, tumor stage, and tumor grade. This article endeavors to elucidate the reciprocal relationship between the SLFN5 gene and malignant tumors, thereby enhancing our comprehension of the intricate mechanisms underlying the SLFN5 gene and its implications for the progression, invasive potential, and metastatic behavior of malignant tumors. At the same time, this paper summarizes the basis of SLFN 5 as a new biomarker of tumor diagnosis and prognosis, and provides new ideas for the target treatment of tumor.

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Low Expression of ZNF154 is Related to Poor Prognosis in Gastric Cancer

Cited by 5 publications

References 31 publications

Integrative analysis indicates the potential values of ANKRD53 in stomach adenocarcinoma

Integrative analysis indicates the potential values of ANKRD53 in stomach adenocarcinoma

Kruppel-family zinc finger proteins as emerging epigenetic biomarkers in head and neck squamous cell carcinoma

Progress in investigating the relationship between Schlafen5 genes and malignant tumors

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