Low‐fat and fat‐free spindle cell lipomas in the oral cavity: Immunohistochemical analysis and review of the literature

Rocha, Audrey Foster Lefort; Miotto, Larissa Natiele; Ferrisse, Túlio Morandin; Silveira, Heitor Albergoni; Almeida, Luciana Yamamoto; Bufalino, Andréia; Navarro, Cláudia Maria; León, Jorge Esquiche

doi:10.1111/cup.13512

Cited by 12 publications

(23 citation statements)

References 13 publications

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“…The key to proper identification lies in the context of the tumor and non-lipogenic component. Recognizing that the spindle cells are microscopically identical to the spindle cell population observed in conventional SCL, regardless of fat content, is crucial 1,8 . In almost all cases, close inspection reveals that the spindle cells are arranged in short parallel bundles 1 .…”

Section: Discussionmentioning

confidence: 89%

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Fat-Free Spindle Cell Lipoma of the Scalp: Lipoma Without a Lipogenic Component

Biagiotti

Khan

Ayrapetyan

et al. 2021

Journal of Craniofacial Surgery

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In contrast, young patients are injured most frequently from focal trauma like assault or contusion. The force from the trauma is transmitted to the orbit contents through the eye. 15,18 Adeyemo et al performed experiments with cadavers to compare the 2 mechanisms. The buckling mechanism caused relatively small-sizedblowout fractures that were limited to the anterior orbital floor, whereas the hydraulic mechanism produced a large-sized-fracture on the orbital floor and medial wall. However, there were no differences in complex blowout fractures among the age groups.This might be attributed to the difference in paranasal anatomy. The ethmoidal cell septa are resistant to this ''hydraulic force'' that reduces the medial wall fracture. 5 The number of ethmoidal cells was significantly higher in the young group, and both bone rigidity and bone flexibility decrease with age, which increases the risk of fracture. 15 In this study, there was a significant difference in fracture site by age. According to previous studies, there is a difference in expected post operative complication depending on the fracture site. 3,20 Therefore, we suggest the need for further study on the difference in the postoperative complication after blowout fracture surgery by age will be needed.This study had several limitations. First, we categorized a fall, slip, car accident as gross trauma and assault, and the causes ranged from sports to focal trauma. However, the mechanism might not have provided enough detail for sufficient classification. Second, we only investigated air cell number and did not examine other factors like anteroposterior length, lamina papyracea area, and anterior height. in addition, it is possible that the ethmoidal cell anatomy was asymmetrical. Third, this study was designed retrospectively and included only Korean patients. The anatomy of the orbit and ethmoid air cell septa differ among races, and results for other populations could differ from the results reported for East Asians.In summary, older patients are more likely to experience medial wall fracture than are younger patients. The results of this study could be attributable to the difference in the anatomy of ethmoidal cells and difference in the cause of blowout fracture.

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Section: Discussionmentioning

confidence: 89%

“…In their investigation, they owe this diagnostic difficulty to the wide-ranging differential that a lipogenic tumor without adipocytic content calls into question. The differential often includes benign nerve sheath tumors including neurofibroma, superficial angiomyx-oma, solitary fibrous tumor, and low-grade sarcomas 1,2,7,8 …”

Section: Discussionmentioning

confidence: 99%

Fat-Free Spindle Cell Lipoma of the Scalp: Lipoma Without a Lipogenic Component

Biagiotti

Khan

Ayrapetyan

et al. 2021

Journal of Craniofacial Surgery

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“…The spindle cells are positive to CD34 and vimentin, and are negative to most other mesenchymal markers, such as actins and desmin, while the adipose cells are positive to S100 protein. It is important to highlight that some SCL can show a very focal, almost absent, adipose component, and immunohistochemistry is essential as an adjunctive diagnostic tool especially in these cases ( 15 ). Loss of chromosomes 13q (13q12 and 13q14-q22) and/or 16q (16q13-qter) seems to be a common genetic background in SCL ( 9 ).…”

Section: Discussionmentioning

confidence: 99%

Large intraoral spindle cell lipoma

Lemos¹,

Cabral²,

Souza³

et al. 2021

J Clin Exp Dent

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Lipomas are relatively common benign neoplasms composed by mature fat cells. Apart from conventional lipomas, several other subtypes have been described in the oral cavity, including fibrolipoma, myxoid lipoma, angiolipoma, myolipoma, chondrolipoma, osteolipoma and spindle cell lipoma (SCL). Intraoral SCL is rare, representing from 1.4% to 9.8% of all intraoral lipomas. The aim of the present study is to report a case of a large intraoral SCL of the buccal mucosa affecting a 46-year-old male, calling attention to its clinical and histological features and to its successfull surgical conservative management. Key words: Lipoma, spindle cell, oral, buccal mucosa.

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“…Mitoses can be rare, while the presence of myxoid matrix is not uncommon [ 8 ]. A more recent and specific histological classification in human medicine (low-fat and fat-rich lipoma) is based on the relative proportions of spindle cells and adipocytes [ 28 ]; to date, this classification has no counterpart in domestic animals [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…In human medicine, lipoma is one of the most common benign mesenchymal neoplasms, and liposarcoma is one of the most common malignant mesenchymal tumors [ 27 ]. Lipomas can be histologically classified as classic lipoma, fibrolipoma, angiolipoma, intramuscular lipoma, chondrolipoma, chondroid lipoma, sialolipoma, and spindle cell lipoma (SCL) based on the histopathological appearance of the tumor stroma [ 28 ]. Histologic spectrum of SCL includes pleomorphic lipoma [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Histological and Ultrastructural Description of Benign Adipocytic Tumors in Farmed Striped Sea Bream (Lythognathus mormyrus)

Orioles

Galeotti

Patarnello

et al. 2021

Animals

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Cutaneous neoplasms affecting wild striped bream (Lythognathus mormyrus) have been recorded after their introduction in a marine aquaculture farm in the Adriatic Sea. The tumors were evident on 24% of the reared fish, showing single or multiple nodules, with a diameter ranging between 0.5–4.0 cm. Histologically, all the neoplastic lesions were located in the stratum spongiosum of the dermis and were surrounded by a thin capsule of connective tissue. The tumors were predominantly composed of adipocytes grouped and surrounded by a thin net of fibroblasts and collagen fibers. In some lipomas a mixture of adipocytes and uniform spindle cells were also observed. Fibroblasts and collagen fibers, or spindle cells, showing few mitotic figures were mainly observed in other nodules. Three of the tumors showed bands of cells with elongated nuclei. Five neoplasms differed from the classic spindle cell lipoma due to the presence of scattered giant cells. These cells presented acidophilic abundant cytoplasm with multiple hyperchromatic nuclei showing a concentric “floret-like” arrangement. The tumors were further characterized by ultrastructural observations that allowed ruling out the presence of virus-like particles within the lesions. Histological features of the masses lead to the identification of four prevalent patterns of neoplasms: lipoma, fibrolipoma, spindle cell lipoma (SCL), and atypical spindle cell-like lipoma (ASCL). The different neoplasms could arise from the transformation of mesenchymal cells of dermal origin. To the author’s knowledge, this is the first report describing key differential histological and ultrastructural features of these neoplasms in striped sea bream.

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Low‐fat and fat‐free spindle cell lipomas in the oral cavity: Immunohistochemical analysis and review of the literature

Cited by 12 publications

References 13 publications

Fat-Free Spindle Cell Lipoma of the Scalp: Lipoma Without a Lipogenic Component

Fat-Free Spindle Cell Lipoma of the Scalp: Lipoma Without a Lipogenic Component

Large intraoral spindle cell lipoma

Histological and Ultrastructural Description of Benign Adipocytic Tumors in Farmed Striped Sea Bream (Lythognathus mormyrus)

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