Low-Fat vs Low-Carbohydrate Diets and Weight Loss

Qi, Lü; Bray, George A.; Sacks, Frank M.

doi:10.1001/jama.2018.6244

Cited by 4 publications

(4 citation statements)

References 7 publications

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“…Nevertheless, a recent meta‐analysis of prospective cohort studies identified potentially undesirable associations of adherence to an LCD with total and cause‐specific mortality [12]. Emerging evidence also underlined the quality rather than the quantity of macronutrient subtypes in LCDs and LFDs [13,14]: Lower intake of carbohydrates from refined grains and added sugar but not from whole grains, and reductions in saturated fat but not unsaturated fat were related to lower risks of mortality [15]. However, the long‐term effects of LCD and LFD on age‐related health outcomes among middle‐aged and older people remain less studied.…”

Section: Introductionmentioning

confidence: 99%

Low‐carbohydrate diets, low‐fat diets, and mortality in middle‐aged and older people: A prospective cohort study

Zhao

Wang

et al. 2023

J Intern Med

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Section: Introductionmentioning

confidence: 99%

Low‐carbohydrate diets, low‐fat diets, and mortality in middle‐aged and older people: A prospective cohort study

Zhao

Wang

et al. 2023

J Intern Med

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“…At present, dietary modification for the treatment and control of NAFLD has received widespread attention as a low-risk and low-cost strategy for patients with NAFLD. Studies have shown that poor dietary habits, such as high calorie, excessive sugar and fat intake, are important factors in the development of NAFLD [8].…”

Section: Analysis Of Domestic and International Research Statusmentioning

confidence: 99%

An Exploration of the Treatment of Non-Alcoholic Fatty Liver Disease Based on Dietary Factors

Yang

2024

BIO Web Conf.

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Non-alcoholic fatty liver disease is a clinical pathological syndrome characterized by diffuse hepatocellular macrovesicular steatosis caused by other liver-damaging factors except for alcohol. At present, there are no specific drugs for non-alcoholic fatty liver disease in the Eastern world or the Western world, so dietary factors play an important role in the prevention and treatment of non-alcoholic fatty liver disease. In this review, we briefly discussed the roles and mechanisms of dietary components (including fructose, protein, and vitamins) in the progression or prevention of non-alcoholic fatty liver disease. Although patients with non-alcoholic fatty liver disease can benefit from weight loss, excessive reduction of food intake can exacerbate fat accumulation in hepatocytes. In addition, we discussed the Mediterranean dietary pattern and compared the effectiveness of low-fat and low-carbohydrate diets in preventing the development of non-alcoholic fatty liver disease.

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“…Negative results of gene–diet interactions on weight loss were also reported in other clinical trials, such as the Diet Intervention Examining The Factors Interacting with Treatment Success (DIETFITS) study (46). Caution is needed in the interpretation of the conflicting findings because of the considerable heterogeneities in the intervention approaches across the various trials and the genetic variants tested (47). Indeed, growing data have shown that the findings of interactions between genetic susceptibility and diet interventions are reproducible (48,49), and large‐scale collaborations of genome‐wide studies are encouraged to identify the genetically determined, personalized response to diets (47).…”

Section: Gene–diet Interactions In Clinical Trialsmentioning

confidence: 99%

Nutrition for precision health: The time is now

2022

Obesity

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Precision nutrition has emerged as a boiling area of nutrition research, with a particular focus on revealing the individual variability in response to diets that is determined mainly by the complex interactions of dietary factors with the multi‐tiered “omics” makeups. Reproducible findings from the observational studies and diet intervention trials have lent preliminary but consistent evidence to support the fundamental role of gene–diet interactions in determining the individual variability in health outcomes including obesity and weight loss. Recent investigations suggest that the abundance and diversity of the gut microbiome may also modify the dietary effects; however, considerable instability in the results from the microbiome research has been noted. In addition, growing studies suggest that a complicated multiomics algorithm would be developed by incorporating the genome, epigenome, metabolome, proteome, and microbiome in predicting the individual variability in response to diets. Moreover, precision nutrition would also scrutinize the role of biological (circadian) rhythm in determining the individual variability of dietary effects. The evidence gathered from precision nutrition research will be the basis for constructing precision health dietary recommendations, which hold great promise to help individuals and their health care providers create precise and effective diet plans for precision health in the future.

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Low-Fat vs Low-Carbohydrate Diets and Weight Loss

Abstract: risks of exogenous testosterone use among men: a systematic review and meta-analysis.

Cited by 4 publications

References 7 publications

Low‐carbohydrate diets, low‐fat diets, and mortality in middle‐aged and older people: A prospective cohort study

Low‐carbohydrate diets, low‐fat diets, and mortality in middle‐aged and older people: A prospective cohort study

An Exploration of the Treatment of Non-Alcoholic Fatty Liver Disease Based on Dietary Factors

Nutrition for precision health: The time is now

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