Low-fluence and low-density CO2 laser: histological analysis of collagen fiber changes in skin and its clinical repercussions in photorejuvenation

Jordão, Juliana Merheb; Stoliar, Mariana Fajgenbaum Feiges; Melo, Sarah Sanches; Campos, Giovana Liz Marioto de; Mesquita, Lismary; Skare, Thelma Larocca

doi:10.1007/s10103-021-03330-0

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…Type I collagen fibers and elastic fibers did not have the same result, with a non-significant increase. The epidermal thickness tends to vary significantly [7].…”

Section: Major Outcomes -Ablative Fractioned Co2 Lasermentioning

confidence: 99%

Major clinical evidence of the optimization of the use of CO2 fractional ablative laser with cells and molecules: a systematic review

Siqueira¹,

Alcântara²,

Peloi³

et al. 2023

MedNEXT

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Introduction: Ablative fractional CO2 laser skin resurfacing describes the process of removing the superficial epidermal and dermal layers of the skin to reduce the cutaneous signs of photoaging. The clinical efficacy and safety of exosomes, adipose tissue stem cells, platelet-rich plasma, and resveratrol as adjuvant therapy after ablative fractional CO2 laser application are evidenced by the world literature. Objective: It was to carry out a systematic review to list the main clinical outcomes of the use of fractional ablative CO2 laser, with or without associated techniques, for facial aesthetic treatment. Methods: The systematic review rules of the PRISMA Platform were followed. The research was carried out from April to May 2023 in Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 86 articles were found. A total of 32 articles were fully evaluated and 17 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 10 studies at high risk of bias and 37 studies that did not meet the GRADE. It was concluded that ablative fractional CO2 laser offers a safe and effective treatment for disfiguring facial scars. It was shown that the improvement in the appearance and quality of the scar was significant for the patient, with a significant impact on the patient's quality of life. Based on these findings, we suggest including ablative fractional CO2 laser in the concept of facial scar treatment. The results demonstrate that the ablative fractional CO2 laser of low fluence and low density is a safe and efficient option for the photorejuvenation of the face. Repeated application of ablative fractional CO2 laser to skin with melasma can result in lasting improvement due to its destructive effect on melanocytes. Furthermore, the combined use of exosome gel with CO2 laser resurfacing would provide synergistic effects on both the efficacy and safety of atrophic acne scarring treatments. ADSC-CM with CO2 resurfacing is a good combination therapy for the treatment of atrophic acne scars and skin rejuvenation. The combined use of ablative fractional CO2 laser and PRP obtained better results. Resveratrol can improve photoaging alone and add efficacy to fractional ablative laser treatment and decrease the adverse effects induced by fractional ablative laser.

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“…Type I collagen fibers and elastic fibers did not have the same result, with a non-significant increase. The epidermal thickness tends to vary significantly [7].…”

Section: Major Outcomes -Ablative Fractioned Co2 Lasermentioning

confidence: 99%

Major clinical evidence of the optimization of the use of CO2 fractional ablative laser with cells and molecules: a systematic review

Siqueira¹,

Alcântara²,

Peloi³

et al. 2023

MedNEXT

View full text Add to dashboard Cite

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“…Fragmentation of collagen fiber with further restructuring of collagen types I and III, activation of fibroblasts occurs after exposure to laser energy. This leads to a decrease in a depth of wrinkles, a tightening of the dermis, and an increase in hydration [55][56][57]. Laser polishing requires special care before and after procedure.…”

Section: сучасні підходи до корекції вікових змін шкіри у жінок г і м...mentioning

confidence: 99%

Modern approaches to the correction of age-related skin changes in women

Makurina,

Siusiuka,

Chornenka

et al. 2023

RHW

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The article is devoted to the literature review on the correction of age-related skin changes in women. Skin aging is a physiological process that is caused by the constant action of unmodified factors, for example, endocrine disorders, shortening of telomeres, etc., in combination with periodic influence of modified (exposomal) factors. Ultraviolet radiation takes first place among external factors affecting the progression of degenerative changes in skin, however, in women, involutional changes in skin are primarily associated with a fading of synthetic function of ovaries. During the first five years from the onset of menopause, content of collagen fibers I and III types is reduced by 30% in combination with a further reduction of 2% annually for the next 15 years.Involutive transformations occur in all layers of skin and are visually characterized by the presence of wrinkles, roughness of the epidermal surface (with photoaging) or a decrease in its thickness (with chronic aging), dryness, pigmentation disorders in the form of uneven hyperpigmented spots, telangiectasias, oval deformations.Today, there are many methods of aesthetic correction of age-related skin changes. In the arsenal of a cosmetologist there are both invasive (PRP-therapy, microneedling, microneedle radio wave lifting, administration of preparations based on calcium hydroxyapatite, polylactic and hyaluronic acid, etc.) and minimally invasive (administration of botulinum neuroprotein, application of chemical acid peelings, IPL-therapy and laser polishing, photodynamic therapy) methods. Patients prefer minimally traumatic procedures due to the fact that they almost do not disturb the processes of socialization, however, each of these methods has both advantages and disadvantages.Modification of a woman life quality in peri- and menopause in form of changes in lifestyle and eating behavior, increasing physical activity, quitting smoking and limiting the use of alcoholic beverages is an integral part of therapeutic care. However, the appointment of menopausal hormonal therapy, including the use of estrogens, progestogens and combined hormonal drugs, allows to achieve a stable and long-lasting effect from cosmetology procedures and home care.

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The phenomenon of skin contraction in CO2 LASER surgical incisions using superpulse and continuous emission mode – preliminary study

Nunes,

Azevedo,

Carreira

2024

Lasers Med Sci

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Low-fluence and low-density CO2 laser: histological analysis of collagen fiber changes in skin and its clinical repercussions in photorejuvenation

Cited by 3 publications

References 22 publications

Major clinical evidence of the optimization of the use of CO2 fractional ablative laser with cells and molecules: a systematic review

Major clinical evidence of the optimization of the use of CO2 fractional ablative laser with cells and molecules: a systematic review

Modern approaches to the correction of age-related skin changes in women

The phenomenon of skin contraction in CO2 LASER surgical incisions using superpulse and continuous emission mode – preliminary study

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