Low fouling electrochemical sensing in complex biological media by using the ionic liquid-doped conducting polymer PEDOT: application to voltammetric determination of dopamine

Song, Zhen; Ge, Shenguang; Cui, Yige; Li, Mengru; Song, Zhiling; Ding, Caifeng; Liu, Xiang

doi:10.1007/s00604-019-3340-x

Cited by 43 publications

(16 citation statements)

References 49 publications

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“…Hence, pH = 7.0 was selected as the optimal pH for the oxidation of DA at the ERGNRs/SPCE surface. This value is similar to the values affirmed in some studies for DA electrooxidation at the surface of different chemically modified electrodes (Table 1) [38][39][40][41][42][43]. Figure 2 shows cyclic voltammetric curves of a 100.0 μM DA (Figure 2(a)) and a 75.0 μM of UA (Figure 2(b)) obtained by the ERGNRs/SPCE (Curve (B)) and an unmodified SPCE (Curve (A)).…”

Section: Electrochemical Characterization Of Ergnrs/spcesupporting

confidence: 87%

Treated Screen Printed Electrodes Based on Electrochemically Reduced Graphene Nanoribbons for the Sensitive Voltammetric Determination of Dopamine in the Presence of Uric Acid

2020

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In this research, the graphene oxide nanoribbons (GONRs) were substantially synthesized by the oxidative longitudinal unzipping of the multi‐walled carbon nanotubes (MWCNTs). Then, a direct electrochemical technique was employed for reducing GONRs adsorbed on the screen printed carbon electrode (SPCE). Electrochemical reduction effectively eliminated the oxygen‐containing groups in the GONRs and produced the electrochemically reduced graphene nanoribbons (ERGNRs). Field emission scanning electron microscopy (FE‐SEM), transmission electron microscopy (TEM), and X‐ray diffraction (XRD) were employed to characterize the materials. The modified SPCE with ERGNRs (ERGNRs/SPCE) displayed acceptable electrocatalytic characteristics towards the oxidation of dopamine (DA) and uric acid (UA) and applied to the simultaneous determination of these two analytes. ERGNRs/SPCE has a peak potential difference of 245 mV between DA and UA. The anodic peak currents of DA and UA were linear within the concentration ranges between 0.5 and 300.0 μM and 1.0 to 400.0 μM in phosphate buffer (pH=7.0) respectively. The detection limit of the technique for DA is 0.15 μM (S/N=3) and for UA is 0.3 μM (S/N=3). The proposed approach has been applied to the determination of DA and UA in real samples and generated acceptable outputs.

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Section: Electrochemical Characterization Of Ergnrs/spcesupporting

confidence: 87%

Treated Screen Printed Electrodes Based on Electrochemically Reduced Graphene Nanoribbons for the Sensitive Voltammetric Determination of Dopamine in the Presence of Uric Acid

2020

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“…The analytes that these electrochemical sensors aim to detect range from biomarkers to therapeutics to omnipresent organic molecules. [ 219 , 220 , 221 , 222 , 223 , 224 , 225 , 226 , 227 , 228 , 229 , 230 , 231 , 232 , 233 , 234 , 235 , 236 ] As mentioned previously, imidazolium and cholinium‐based ionic liquids have been widely used in biomedicine, which holds true for biosensors. Choline dihydrogen phosphate and 1‐butyl‐3‐methylimidazolium tetrafluoroborate (BMIM[BF 4 ]) coated electrodes with immobilized antibodies were used to detect cortisol and interleukin‐6 in human sweat.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Recent Advances in Ionic Liquids in Biomedicine

2021

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The use of ionic liquids and deep eutectic solvents in biomedical applications has grown dramatically in recent years due to their unique properties and their inherent tunability. This review will introduce ionic liquids and deep eutectics and discuss their biomedical applications, namely solubilization of drugs, creation of active pharmaceutical ingredients, delivery of pharmaceuticals through biological barriers, stabilization of proteins and other nucleic acids, antibacterial agents, and development of new biosensors. Current challenges and future outlooks are discussed, including biocompatibility, the potential impact of the presence of impurities, and the importance of understanding the microscopic interactions in ionic liquids in order to design task-specific solvents.

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“…Simultaneous detection gave LOD values of 50 nM (UA), 20 nM (DA), and 1.0 µM (AA) in PBS solution at pH 6. Poly (3,4-ethylenedioxythiophene) doped with ionic liquid (1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide) on glassy carbon electrode (PEDOT/IL/GCE) has been also used as biofouling resistant DA electrode showing porous microstructure, high electrical conductivity, and good stability [ 117 ]. LOD and linear range values of 33 nM and 0.2 μM to 328 μM, respectively, were found for DA sensing in presence of proteins such as bovine serum albumin (BSA), human serum albumin (HSA), and chicken egg white lysozyme (LZM).…”

Section: Electrochemical Sensors Based On Conducting Polymersmentioning

confidence: 99%

Electrochemical Sensors Based on Conducting Polymers for the Aqueous Detection of Biologically Relevant Molecules

et al. 2021

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Electrochemical sensors appear as low-cost, rapid, easy to use, and in situ devices for determination of diverse analytes in a liquid solution. In that context, conducting polymers are much-explored sensor building materials because of their semiconductivity, structural versatility, multiple synthetic pathways, and stability in environmental conditions. In this state-of-the-art review, synthetic processes, morphological characterization, and nanostructure formation are analyzed for relevant literature about electrochemical sensors based on conducting polymers for the determination of molecules that (i) have a fundamental role in the human body function regulation, and (ii) are considered as water emergent pollutants. Special focus is put on the different types of micro- and nanostructures generated for the polymer itself or the combination with different materials in a composite, and how the rough morphology of the conducting polymers based electrochemical sensors affect their limit of detection. Polypyrroles, polyanilines, and polythiophenes appear as the most recurrent conducting polymers for the construction of electrochemical sensors. These conducting polymers are usually built starting from bifunctional precursor monomers resulting in linear and branched polymer structures; however, opportunities for sensitivity enhancement in electrochemical sensors have been recently reported by using conjugated microporous polymers synthesized from multifunctional monomers.

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Low fouling electrochemical sensing in complex biological media by using the ionic liquid-doped conducting polymer PEDOT: application to voltammetric determination of dopamine

Cited by 43 publications

References 49 publications

Treated Screen Printed Electrodes Based on Electrochemically Reduced Graphene Nanoribbons for the Sensitive Voltammetric Determination of Dopamine in the Presence of Uric Acid

Treated Screen Printed Electrodes Based on Electrochemically Reduced Graphene Nanoribbons for the Sensitive Voltammetric Determination of Dopamine in the Presence of Uric Acid

Recent Advances in Ionic Liquids in Biomedicine

Electrochemical Sensors Based on Conducting Polymers for the Aqueous Detection of Biologically Relevant Molecules

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