Low-frequency axial ultrasound velocity correlates with bone mineral density and cortical thickness in the radius and tibia in pre- and postmenopausal women

Kilappa, Vantte; Moilanen, Petro; Xu, Leiting; Nicholson, Patrick; Timonen, J.; Cheng, Sulin

doi:10.1007/s00198-010-1273-7

Cited by 40 publications

(25 citation statements)

References 47 publications

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“…To this end, we consider, in particular, our clinical six-element piezo array (Kilappa et al, 2011). We previously excited the FFGW at 120 kHz using a single element of this array , but our recent findings suggest that the efficiency of FFGW excitation can also be enhanced by lowering the frequency, e.g., to 50 kHz (Moilanen et al, 2014).…”

Section: Introductionmentioning

confidence: 98%

Tailoring the excitation of fundamental flexural guide waves in coated bone by phase-delayed array: Two-dimensional simulations

Kilappa

Moilanen

Salmi

et al. 2015

The Journal of the Acoustical Society of America

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The fundamental flexural guided wave (FFGW) enables ultrasonic assessment of cortical bone thickness. In vivo, it is challenging to detect this mode, as its power ratio with respect to disturbing ultrasound is reduced by soft tissue covering the bone. A phase-delayed ultrasound source is proposed to tailor the FFGW excitation in order to improve its power ratio. This situation is analyzed by 2D finite-element simulations. The soft tissue coating (7-mm thick) was simulated as a fluid covering an elastic plate (bone, 2-6 mm thick). A six-element array of emitters on top of the coating was excited by 50-kHz tone bursts so that each emitter was appropriately delayed from the previous one. Response was recorded by an array of receivers on top of the coating, 20-50 mm away from the closest emitter. Simulations predicted that such tailored/phase-delayed excitations should improve the power ratio of FFGW by 23 ± 5 dB, independent of the number of emitters (N). On the other hand, the FFGW magnitude should increase by 5.8 ± 0.5 dB for each doubling of N. This suggests that mode tailoring based on phase-delayed excitation may play a key role in the development of an in vivo FFGW assessment.

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Section: Introductionmentioning

confidence: 98%

Tailoring the excitation of fundamental flexural guide waves in coated bone by phase-delayed array: Two-dimensional simulations

Kilappa

Moilanen

Salmi

et al. 2015

The Journal of the Acoustical Society of America

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“…SOS in osteoporotic and healthy human cortex has been shown to vary from 3,200 (±307) to 3,485 (±128)m/s [12,35]. The axial SOS in tibia of pre-and postmenopausal women is reduced approximately 100 m/s between the ages of 25 and 85 years, the annual decrease being −2.7 m/s in postmenopausal women [25]. Provided that a similar change of SOS in Table 5 The AUC for different ROC models, in the discrimination of fracture subjects from non-fracture individuals…”

Section: Discussionmentioning

confidence: 97%

Multi-site bone ultrasound measurements in elderly women with and without previous hip fractures

et al. 2011

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“…As a result, the in vivo precision (CV rms ) was limited. During the follow-up period of the study, significant mechanical improvements were implemented in the device, and a CV of 0.5% could be achieved with the latest device version [5,26]. Obviously, this valuable information available after the device improvement cannot retrospectively improve the quality of the results presented here.…”

Section: Discussionmentioning

confidence: 98%

“…A novel low-frequency (LF) axial transmission QUS method for assessing the properties of cortical bone has been shown to reflect bone density and cortical thickness [5-7]. A relationship between the LF tibial velocity (V LF ) and geometry of proximal femur in older women has also been suggested [8].…”

Section: Introductionmentioning

confidence: 99%

Association between low-frequency ultrasound and hip fractures - comparison with DXA-based BMD

Määttä

Moilanen

Timonen

et al. 2014

BMC Musculoskelet Disord

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BackgroundNew methods for diagnosing osteoporosis and evaluating fracture risk are being developed. We aim to study the association between low-frequency (LF) axial transmission ultrasound and hip fracture risk in a population-based sample of older women.MethodsThe study population consisted of 490 community-dwelling women (78–82 years). Ultrasound velocity (VLF) at mid-tibia was measured in 2006 using a low-frequency scanning axial transmission device. Bone mineral density (BMD) at proximal femur measured using dual-energy x-ray absorptiometry (DXA) was used as the reference method. The fracture history of the participants was collected from December 1997 until the end of 2010. Lifestyle-related risk factors and mobility were assessed at 1997.ResultsDuring the total follow-up period (1997–2010), 130 women had one or more fractures, and 20 of them had a hip fracture. Low VLF (the lowest quartile) was associated with increased hip fracture risk when compared with VLF in the normal range (Odds ratio, OR = 3.3, 95% confidence interval (CI) 1.3-8.4). However, VLF was not related to fracture risk when all bone sites were considered. Osteoporotic femoral neck BMD was associated with higher risk of a hip fracture (OR = 4.1, 95% CI 1.6-10.5) and higher risk of any fracture (OR = 2.4, 95% CI 1.6-3.8) compared to the non-osteoporotic femoral neck BMD. Decreased VLF remained a significant risk factor for hip fracture when combined with lifestyle-related risk factors (OR = 3.3, 95% CI 1.2-9.0).ConclusionLow VLF was associated with hip fracture risk in older women even when combined with lifestyle-related risk factors. Further development of the method is needed to improve the measurement precision and to confirm the results.

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Low-frequency axial ultrasound velocity correlates with bone mineral density and cortical thickness in the radius and tibia in pre- and postmenopausal women

Cited by 40 publications

References 47 publications

Tailoring the excitation of fundamental flexural guide waves in coated bone by phase-delayed array: Two-dimensional simulations

Tailoring the excitation of fundamental flexural guide waves in coated bone by phase-delayed array: Two-dimensional simulations

Multi-site bone ultrasound measurements in elderly women with and without previous hip fractures

Association between low-frequency ultrasound and hip fractures - comparison with DXA-based BMD

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