2009
DOI: 10.1186/1471-2202-10-138
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Low-frequency BOLD fluctuations demonstrate altered thalamocortical connectivity in diabetic neuropathic pain

Abstract: BackgroundIn this paper we explored thalamocortical functional connectivity in a group of eight patients suffering from peripheral neuropathic pain (diabetic pain), and compared it with that of a group of healthy subjects. We hypothesized that functional interconnections between the thalamus and cortex can be altered after years of ongoing chronic neuropathic pain.ResultsFunctional connectivity was studied through a resting state functional magnetic resonance imaging (fMRI) paradigm: temporal correlations betw… Show more

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Cited by 104 publications
(58 citation statements)
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“…However, whole-brain imaging studies in patients with chronic neuropathic pain clearly identifies a range of plastic changes at the supraspinal level that include alterations of somatotopic maps, cortical thickness, and excitability in the S1 cortex (15,(40)(41)(42). Such anatomical and functional changes in the connectivity between the "pain matrix" cortical regions are reliable predictors for the severity of peripheral neuropathic pain (43,44). Our results extend this to show that changes in cortical neural circuits are not simply passive reflections of ongoing altered afferent input from the spinal areas, but actively contribute to neuropathic mechanical allodynia.…”
Section: Discussionmentioning
confidence: 99%
“…However, whole-brain imaging studies in patients with chronic neuropathic pain clearly identifies a range of plastic changes at the supraspinal level that include alterations of somatotopic maps, cortical thickness, and excitability in the S1 cortex (15,(40)(41)(42). Such anatomical and functional changes in the connectivity between the "pain matrix" cortical regions are reliable predictors for the severity of peripheral neuropathic pain (43,44). Our results extend this to show that changes in cortical neural circuits are not simply passive reflections of ongoing altered afferent input from the spinal areas, but actively contribute to neuropathic mechanical allodynia.…”
Section: Discussionmentioning
confidence: 99%
“…It is well accepted that chronic pain, ultimately reflects functional changes in the brain, in particular in the thalamocortical connections/interactions (Cauda et al, 2009;Cheong et al, 2011;Walton et al, 2010). With respect to structural cortical changes, most of those that have been found to be associated with neuropathic pain have been observed in animals and patients that have been experiencing neuropathic pain for a long period.…”
Section: Peripheral Nerve Injury Alters the Dorsal Root Ganglia Envirmentioning
confidence: 99%
“…Brain imaging has revealed the impact of peripheral neuropathy on the central nervous system. For example, in diabetic neuropathy the somatosensory cortex is smaller [7] while in painful diabetic neuropathy resting state network connectivity is altered [20][21][22].…”
Section: Introductionmentioning
confidence: 99%