Low Frequency Electromagnetic Fields Might Increase the Effect of Enamel Matrix Derivative on Periodontal Tissues

Abstract

Periodontal regeneration is a complex goal, which is commonly pursued with a combination of surgical techniques, biomaterials, and bioactive compounds. One such compound is enamel matrix derivative (EMD), a medical substance that is extracted from porcine tooth germs and which contains several protein fractions with BMP- and TGF-β-like action. Activation of TGF-β signaling is required for EMD activity on cells and tissues, and a growing body of evidence indicates that EMD largely relies on this pathway. As low frequency electromagnetic fields (EMFs) have long been investigated as a tool to promote bone formation and osteoblast activity, and because recent studies have reported that the effects of EMFs on cells require primary cilia, by modulating the presence of membrane-bound receptors (e.g., for BMP) or signal mediators, it can be hypothesized that the application of EMFs may increase cell sensitivity to EMD: as TGFBR receptors have also been identified on primary cilia, EMFs could make cells more responsive to EMD by inducing the display of a higher number of receptors on the cellular membrane.

Radiasi Medan Elektromagnetik pada Jangkauan Frekuensi Sangat Rendah (Extremely Low Frequency) di Lingkungan Kampus Universitas PGRI Yogyakarta

“…Paparan medan elektromagnetik ELF telah dianggap bersifar karsinogenik berdasarkan beberapa penelitian dalam sepuluh tahun terakhir. Adanya peningkatan risiko leukimia pada anak-anak dan tumor otak pada orang dewasa pasca paparan radiasi medan elektromagnetik secara berkala dilaporkan oleh beberapa penelitian epidemiologi (Guizzardi & Pedrazzi, 2021;Touitou, Selmaoui, & Lambrozo, 2022). Risiko leukimia pada anak-anak meningkat karena paparan radiasi elektromagnetik ELF lebih dari 0,4 T secara berkala.…”