Low frequency haplotypes of E-selectin polymorphisms G2692A and C1901T give increased protection from coronary artery disease

Gorący, Jarosław; Gorący, Iwona; Kaczmarczyk, Mariusz; Parczewski, Miłosz; Brykczyński, Mirosław; Jw, Clark; Safranow, Krzysztof; Ciechanowicz, Andrzej

doi:10.12659/msm.881806

Cited by 13 publications

(2 citation statements)

References 29 publications

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“…Recently, results from a meta-analysis reported that the SELE gene A561C polymorphism was significantly associated with susceptibility to ischemic stroke, which results from cerebrovascular atherosclerosis [57] . Several polymorphisms in the SELE gene, such as A561C [32] , G98T [35] , L554F [20] , G2692A and C1091T [58] , were successively reported to be associated with atherosclerosis and CAD. Sarecka-Hujar et al suggested that the two SNPs of the SELE gene, A561C and G98T, were likely to control the SELE expression [21] .…”

Section: Discussionmentioning

confidence: 99%

Association of A561C and G98T Polymorphisms in E-Selectin Gene with Coronary Artery Disease: A Meta-Analysis

Wang

Zhang

et al. 2013

PLoS ONE

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ObjectiveE-selectin (SELE) mediates the rolling and adhesion of leukocytes on activated endothelial cells and plays a critial role in the pathogenesis of coronary artery disease (CAD). Associatons between the A561C and G98T polymorphisms of the SELE gene and CAD risk were investigated broadly, but the results were inconsistent. In the present study, we performed a meta-analysis to systematically evaluate the associations between the two polymorphisms and the risk of CAD.MethodsComprehensive research was conducted to identify relevant studies. The fixed or random effect model was selected based on the heterogeneity among studies, which was evaluated with Q-test and Ι2. Meta-regression was used to explore the potential sources of between-study heterogeneity. Peters's linear regression test was used to estimate the publication bias.ResultsOverall, 24 articles involving 3694 cases and 3469 controls were included. After excluding articles deviating from Hardy–Weinberg equilibrium in controls and sensitive analysis, our meta-analysis showed a significant association between the A561C ploymprphism and CAD in dominant (OR = 1.84, 95% CI = 1.56–2.16) and codominant (OR = 1.74, 95% CI = 1.49–2.03) models. As for the G98T polymorphism, significantly increased CAD risk was observed in dominant (OR = 1.47, 95% CI = 1.16–1.87) and codominant (OR = 1.48, 95% CI = 1.18–1.86) models, but after subgroup analysis, the association was not significant among Caucasians in dominant (OR = 1.58, 95% CI = 0.73–3.41) and codominant (OR = 1.58, 95% CI = 0.79–3.20) models.ConclusionsDespite some limitations, our meta-analysis suggested that the SELE gene polymorphisms (A561C, G98T) were significantly associated with increased risk of CAD. However, after subgroup analysis no significant association was found among Caucasians for the G98T polymorphism, which may be due to the small sample size and other confounding factors. Future investigations with multicenter, large-scale, and multi-ethnic groups are needed.

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Section: Discussionmentioning

confidence: 99%

Association of A561C and G98T Polymorphisms in E-Selectin Gene with Coronary Artery Disease: A Meta-Analysis

Wang

Zhang

et al. 2013

PLoS ONE

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“…Moreover, recent studies in a German population showed possible associations between the S128R and L554F variations of the E-selectin gene and severe atherosclerosis, hypertension and cerebrovascular diseases (12,13). However, the low frequency haplotypes of E-selectin polymorphisms G2692A and C1901T is currently considered to be protective for coronary artery disease (14). Additionally, the association between SELE SNPs and the E-selectin level remains controversial (15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

Associations SELE Gene Haplotype Variant and Hypertension in Mongolian and Han Populations

Zhao

Liu

et al. 2015

Intern. Med.

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Genetic variation is thought to contribute to the etiology of hypertension, and E-selectin is a candidate essential hypertension-associated gene. Objective In this study, we attempted to test the hypothesis that subtle haplotype variants of SELE genes may be sources of essential hypertension in Mongolian and Han populations. Materials A total of 429 unrelated Mongolian herdsmen and 416 Han farmers were enrolled, including 212 Mongolian essential hypertension (EH) patients, 217 Mongolian normotensives (controls), 200 Han EH patients and 216 Han normotensives (controls). Methods All nine tag single-nucleotide polymorphisms (SNPs) within the SELE gene were retrieved from HapMap and the genotyping was performed using a polymerase chain reaction (PCR)/ligase detection reaction assay. Results The distributions of the A-allele frequency of rs3917458 and the C-allele frequency of rs2179172 differed significantly between the hypertensive subjects and controls in the Han population. The frequency of haplotype GGC was significantly higher in the EH group than in the controls in the Mongolian population. In the Han population, a significant difference was observed in the haplotype frequency of TCC between the patients and controls, whereas haplotype ACA was detected significantly less often in the EH subjects than in the controls. Conclusion Meanwhile, the haplotype TCC in the Han hypertensive patients and the haplotype GGC in the Mongolian patients had independent effects in increasing the risk for EH and maybe used as risk factors for predicting high blood pressure. However, the haplotype ACA had an independent effect in decreasing the risk of hypertension and may be protective in normotensive subjects in the Han population. Therefore, multiple SNPs in combination in SELE may confer a risk of hypertension.

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RETRACTED ARTICLE: Correlations of SELE genetic polymorphisms with risk of coronary heart disease and myocardial infarction: a meta-analysis

Zhao

2014

Mol Biol Rep

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This meta-analysis of case-control studies was conducted to determine whether SELE genetic polymorphisms contribute to the pathogenesis of coronary heart disease (CHD) and myocardial infarction (MI). The PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, Cochrane Library, and CBM databases were searched for relevant articles published before November 1st, 2013 without any language restrictions. Meta-analysis was conducted using the STATA 12.0 software. Twenty case-control studies met the inclusion criteria, with a total of 2,292 CHD patients, 901 MI patients and 3,233 healthy controls. Six common polymorphisms in the SELE gene were evaluated, including 554L/F, 98G/T, 128S/R, 2692G/A, 1901C/T, and 1856A/G. The results of our meta-analysis suggest that SELE genetic polymorphisms might be strongly correlated with an increased risk of CHD (allele model: OR 2.08, 95% CI 1.67-2.58, P<0.001; dominant model: OR 2.12, 95% CI 1.68-2.68, P<0.001; respectively), especially the SELE 554L/F, 98G/T and 128S/R polymorphisms. Furthermore, our findings indicated that SELE genetic polymorphisms were closely linked to the risk of CHD in Asians but not Caucasians. However, our findings reveal no positive correlations between SELE genetic polymorphisms and MI risk (allele model: OR 1.39, 95% CI 1.00-1.94, P=0.054; dominant model: OR 1.40, 95% CI 0.96-2.04, P=0.081; respectively). The current meta-analysis suggests that SELE genetic polymorphisms may contribute to an increased risk of CHD, especially the SELE 554L/F, 98G/T and 128S/R polymorphisms in Asians. However, SELE genetic polymorphisms may not be important determinants of susceptibility to MI.

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Low frequency haplotypes of E-selectin polymorphisms G2692A and C1901T give increased protection from coronary artery disease

Cited by 13 publications

References 29 publications

Association of A561C and G98T Polymorphisms in E-Selectin Gene with Coronary Artery Disease: A Meta-Analysis

Association of A561C and G98T Polymorphisms in E-Selectin Gene with Coronary Artery Disease: A Meta-Analysis

Associations SELE Gene Haplotype Variant and Hypertension in Mongolian and Han Populations

RETRACTED ARTICLE: Correlations of SELE genetic polymorphisms with risk of coronary heart disease and myocardial infarction: a meta-analysis

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