Low frequency of cervicocranial artery involvement in Japanese with renal artery fibromuscular dysplasia compared with that of Caucasians

Mishima, Eikan; Umezawa, Shu; Suzuki, Takehiro; Fujimura, Miki; Abe, Michiaki; Hashimoto, Junichiro; Abe, Takaaki; Ito, Sadayoshi

doi:10.1007/s10157-018-1575-1

Cited by 6 publications

(6 citation statements)

References 35 publications

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“…2 a), and the proportion of male patients with focal FMD was higher (41 % vs. 0 %, p = 0.01; Fig. 2 a), which is similar to a previous report [11]. However, although the rate of recurrence was not different between the two types (multifocal FMD: 36.3 % vs. focal FMD: 33.3 %, p = > 0.99), the period until the recurrence of multifocal FMD was longer than that of focal FMD (multifocal FMD: 8.3 ± 6.8 years vs. focal FMD: 0.9 ± 1.1 years, p = 0.03).…”

Section: Additional Investigationssupporting

confidence: 91%

“…Thus, following up patients with multifocal FMD yearly, but for a longer period of at least 10 years or more, might be necessary. Although several studies have compared other clinical findings such as renal function, BP, median age at diagnosis, and affected vascular regions between the two types of FMD, [9][10][11] they have not discussed any difference in the period until recurrence between the types. Future trials should focus on the types of FMD and the age at diagnosis to investigate the long-term clinical outcomes of PTRA.…”

Section: Discussionmentioning

confidence: 99%

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Fibromuscular dysplasia with recurrence after “long-term” following percutaneous transcatheter renal angioplasty: two case reports with a review of 26 patients

et al. 2021

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Background Fibromuscular dysplasia (FMD) often causes renal artery stenosis with renovascular hypertension. Recent clinical outcomes encourage percutaneous transluminal renal angioplasty (PTRA) to treat FMD; however, the necessary follow-up period remains unclear. Moreover, previous studies have not revealed the difference in the period until recurrence between two major types of FMD—multifocal and focal. Case presentation We describe two patients with multifocal FMD who developed hypertension during their teenage years and had recurrence of FMD > 10 years after PTRA. We further examined the types of FMD and age of onset in 26 patients who underwent PTRA. The period until recurrence of multifocal FMD was longer than that of focal FMD. Moreover, patients with early-onset multifocal FMD are likely to have a delayed recurrence after PTRA compared to other types. Conclusions Our report suggests that patients with multifocal FMD, especially those with onset at an early age, may need long-term follow-up for at least ≥ 10 years.

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Section: Additional Investigationssupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Fibromuscular dysplasia with recurrence after “long-term” following percutaneous transcatheter renal angioplasty: two case reports with a review of 26 patients

et al. 2021

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“…To the best of our knowledge, the present study provided the largest number of individuals with renal artery FMD in China. A total of 245 patients with renal artery FMD were enrolled, which is far more than in other studies involving Eastern Asian populations [14,15,25]. In this study, the mean age at diagnosis of FMD was 26.9 years, which was similar to previous reports from other East Asian countries but much younger than the patients in the U.S.…”

Section: Discussionsupporting

confidence: 76%

“…In the U.S. and the European/International registry, only 0.5% [10] and 7.2% [5] were Asians, respectively. Moreover, the clinical phenotype of patients with FMD greatly differed between Asians and whites [14,15]. Yet, these were small sample size and single-centre studies.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and clinical characteristics of renovascular hypertension associated with fibromuscular dysplasia in China

Kang¹,

Chen²,

Wu³

et al. 2023

Journal of Hypertension

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The aim of this study was to investigate the clinical characteristics of renal artery fibromuscular dysplasia (FMD) in patients in China and identify the cure rate of hypertension after angioplasty.Methods: Consecutive hypertensive patients with renal artery stenosis caused by FMD who underwent catheterbased angiography, and were followed at two Chinese referral centres, were retrospectively analysed. All patients underwent a detailed investigation, including demographic characteristics, clinical characteristics, biochemical sampling, Doppler ultrasonography of carotid arteries, magnetic resonance angiography (MRA) of the intracranial artery, and CTA or MRA of the abdominal artery and catheter-based renal angiography. Patients were routinely followed up at 1 month, 6 months and every year after the procedure.Results: Among 245 study participants, with a mean diagnosed age of 26.9 AE 9.9 years, 137 (55.9%) were women, and 38 (15.5%) were children. All patients were diagnosed with hypertension at a mean age of 23.4 AE 8.4 years. There were 73.5% focal and 15.2% multivessel cases. Aneurysms, arterial dissections and total occlusions were found in 21.6, 4.1 and 12.2% of patients, respectively. Patients with multifocal FMD were older (26.0 vs. 23.7 years, P ¼ 0.021) and more often female (70.8 vs. 50.6%, P ¼ 0.004). Among children with renal FMD, 55.2% were men, and 86.8% were focal. After a median follow-up of 7.0 years, multifocal FMD had a higher cure rate of hypertension than focal FMD after revascularization (71.7 vs. 55.8%, P ¼ 0.032). Conclusion:In a cohort of mostly young Chinese patients, the prevalence of hypertension associated with renal FMD is similar in both sexes. Focal FMDs were more frequent than the multifocal ones and, after angioplasty, were associated with a worse blood pressure outcome.

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“…The distribution of arterial involvement involves renal arteries (60%–75%), carotid or vertebral arteries (23%–30%), multiple vascular beds (28%), other arterial beds such as iliac, popliteal, splanchnic, hepatic, subclavian, brachial, aorta, lower limb vessels uncommon with exact frequency unknown 3. In a large study of symptomatic renal or intracranial FMD patients, additional imaging identified multisite involvement in 48% of patients,4 although there may be racial differences with lower rates of multisite involvement seen in a study of Japanese FMD patients 5. Review of the literature on FMD affecting lower limb vasculature is limited to case reports and a small case series 2 6–9.…”

Section: Discussionmentioning

confidence: 99%

Fibromuscular dysplasia presenting with a deep vein thrombosis

et al. 2020

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A 41-year-old male patient presented with isolated right lower limb swelling. An ultrasound scan showed right external iliac and femoral vein deep vein thrombosis due to extrinsic compression by an aneurysm of the right common iliac artery. Investigations including imaging and a tissue biopsy of right and left femoral arteries confirmed a rare clinical presentation of fibromuscular dysplasia involving iliac, coeliac, renal and pulmonary vessels. The common iliac artery aneurysm was successfully treated with endovascular repair. Six months later, he developed coronary artery involvement with spontaneous dissection of left anterior descending artery diagnosed on coronary angiogram which was managed conservatively. At 6-year follow-up, he remains clinically asymptomatic and continues with regular surveillance imaging. Iliac arterial fibromuscular dysplasia is uncommon and clinical presentation with a complication such as a deep vein thrombosis is atypical.

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Low frequency of cervicocranial artery involvement in Japanese with renal artery fibromuscular dysplasia compared with that of Caucasians

Cited by 6 publications

References 35 publications

Fibromuscular dysplasia with recurrence after “long-term” following percutaneous transcatheter renal angioplasty: two case reports with a review of 26 patients

Fibromuscular dysplasia with recurrence after “long-term” following percutaneous transcatheter renal angioplasty: two case reports with a review of 26 patients

Prevalence and clinical characteristics of renovascular hypertension associated with fibromuscular dysplasia in China

Fibromuscular dysplasia presenting with a deep vein thrombosis

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