Low-frequency oscillations measured in the periphery with near-infrared spectroscopy are strongly correlated with blood oxygen level-dependent functional magnetic resonance imaging signals

Abstract

Abstract. Low-frequency oscillations (LFOs) in the range of 0.01-0.15 Hz are commonly observed in functional imaging studies, such as blood oxygen level-dependent functional magnetic resonance imaging (BOLD fMRI) and functional near-infrared spectroscopy (fNIRS). Some of these LFOs are nonneuronal and are closely related to autonomic physiological processes. In the current study, we conducted a concurrent resting-state fMRI and NIRS experiment with healthy volunteers. LFO data was collected simultaneously at peripheral sites (middle fingertip and big toes) by NIRS, and centrally in the brain by BOLD fMRI. The cross-correlations of the LFOs collected from the finger, toes, and brain were calculated. Our data show that the LFOs measured in the periphery (NIRS signals) and in the brain (BOLD fMRI) were strongly correlated with varying time delays. This demonstrates that some portion of the LFOs actually reflect systemic physiological circulatory effects. Furthermore, we demonstrated that NIRS is effective for measuring the peripheral LFOs, and that these LFOs and the temporal shifts between them are consistent in healthy participants and may serve as useful biomarkers for detecting and monitoring circulatory dysfunction.

Correlation between asymmetry of spontaneous oscillation of hemodynamic changes in the prefrontal cortex and anxiety levels: a near-infrared spectroscopy study

“…Spontaneous hemodynamic oscillation in the resting brain has previously been detected not only with NIRS 31-34 but also with blood oxygen level-dependent functional MRI (fMRI). [35][36][37][38][39] Although the origin and function of the spontaneous oscillation remain unclear, two possibilities have been proposed. First, a part of the spontaneous oscillations in the brain could originate from the global circulation.…”

“…The second possibility is that the spontaneous oscillation of oxy-Hb might reflect resting state neural activity. 29,31,[35][36][37][38][39] In NIRS activation studies, changes of oxy-Hb during activation imply evoked changes of rCBF in response to neuronal activation, since changes in oxy-Hb are correlated with changes in rCBF. 10 In addition, simultaneous measurements of NIRS and EEG at rest demonstrated a relationship between oxy-Hb change and mean EEG peak frequency.…”

Design of multichannel functional near-infrared spectroscopy system with application to propofol and sevoflurane anesthesia monitoring

“…Third, the hemodynamic parameters HbO 2 and Hb oscillating at 0.01 to 0.15 Hz are believed to be closely related to brain activation. 16 The A5 component (<0.15 Hz) was used to extract the relative concentration changes of HbO 2 , Hb, and total hemoglobin (HbT; HbT ¼ HbO 2 þ Hb). The 10 s data prior to anesthesia induction were used as the baseline during the calculation of relative HbO 2 and Hb (using MBLL).…”

“…fNIRS supplies a safe, nonionizing radiative, noninvasive, and cost-effective measurement of cerebral hemodynamic changes in cerebral cortex in comparison with positron emission tomography (PET) and functional magnetic resonance imaging (fMRI). 16,17 Over the years, this technique has evolved into a versatile medical diagnostic modality and has been used to investigate many brain functions. [18][19][20][21][22][23] In general, there are three types of fNIRS systems: continuous wave (CW) modality, frequency-domain (FD) modality, and time-domain modality.…”

The Sixth Sense-Emotional Contagion; Review of Biophysical Mechanisms Influencing Information Transfer in Groups

“…It was found that blood in the body is sensitive to a magnetic field coming from a particular direction, [152] [153], Iron in heme appears to have anisotropic (directionally sensitive) qualities at room temperature, [154], paramagnetic neurotransmitters are concentrated in the mesencephalon, (used by the body for reward and addiction) [155].…”