Low-frequency sonophoresis: application to the transdermal delivery of macromolecules and hydrophilic drugs

Polat, Barış; Blankschtein, Daniel; Langer, Robert

doi:10.1517/17425247.2010.538679

Cited by 149 publications

(102 citation statements)

References 95 publications

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“…Using LFS, the large bubbles form outside the skin, become unstable and implode powerfully near the solid stratum corneum surface resulting in a jet of fluid, referred to microjet. When these microjets affect the stratum corneum, they erode the dead cells and help to permeate the membrane [35][36][37]. Tang et al definitively demonstrated by an experimental study that ultrasound-induced cavitation is the key mechanism via which LFS permeates the skin.…”

Section: Sonophoresismentioning

confidence: 99%

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Canavese

Ancona

Racca

et al. 2018

Chemical Engineering Journal

351

247

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• Ultrasound-based therapies are opening new horizons in the oncological field.• Innovative and promising solutions derive from different nanoparticles-assisted ultrasound treatments.• Sonodynamic therapy (SDT) emerged recently as a novel approach for cancer treatment.• Different and complex cell death mechanisms are involved in nanoparticles-assisted SDT.• Nanoparticles-assisted ultrasound is still at its infancy in clinics. A R T I C L E I N F O Keywords:Inertial cavitation Reactive oxygen species Sonoluminescence Sonodynamic Tumor Therapy Cytotoxicity A B S T R A C TAt present, ultrasound radiation is broadly employed in medicine for both diagnostic and therapeutic purposes at various frequencies and intensities. In this review article, we focus on therapeutically-active nanoparticles (NPs) when stimulated by ultrasound. We first introduce the different ultrasound-based therapies with special attention to the techniques involved in the oncological field, then we summarize the different NPs used, ranging from soft materials, like liposomes or micro/nano-bubbles, to metal and metal oxide NPs. We therefore focus on the sonodynamic therapy and on the possible working mechanisms under debate of NPs-assisted sonodynamic treatments. We support the idea that various, complex and synergistics physical-chemical processes take place during acoustic cavitation and NP activation. Different mechanisms are therefore responsible for the final cancer cell death and strongly depends not only on the type and structure of NPs or nanocarriers, but also on the way they interact with the ultrasonic pressure waves. We conclude with a brief overview of the clinical applications of the various ultrasound therapies and the related use of NPs-assisted ultrasound in clinics, showing that this very innovative and promising approach is however still at its infancy in the clinical cancer treatment.

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Section: Sonophoresismentioning

confidence: 99%

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Canavese

Ancona

Racca

et al. 2018

Chemical Engineering Journal

351

247

View full text Add to dashboard Cite

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“…To date, LFS has been shown to enhance dermal penetration of various other macromolecules including cyclosporine A [74], antisense oligonucleotides [75] and tetanus toxoid [76] as well as a large number of small molecules. For a detailed list of studied molecules, see Polat et al [77]. Lopez 11 , Seto 12 , Blankschtein and Langer also showed that LFS can enhance the delivery of nanoparticles into the skin.…”

Section: Sonophoresismentioning

confidence: 99%

Engineering Approaches to Transdermal Drug Delivery: A Tribute to Contributions of Prof. Robert Langer

Mitragotri

2013

Skin Pharmacol Physiol

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Transdermal drug delivery continues to provide an advantageous route of drug administration over injections. While the number of drugs delivered by passive transdermal patches has increased over the years, no macromolecule is currently delivered by the transdermal route. Substantial research efforts have been dedicated by a large number of researchers representing varied disciplines including biology, chemistry, pharmaceutics and engineering to understand, model and overcome the skin's barrier properties. This article focuses on engineering contributions to the field of transdermal drug delivery. The article pays tribute to Prof. Robert Langer, who pioneered the engineering approach towards transdermal drug delivery. Over a period spanning nearly 25 years since his first publication in the field of transdermal drug delivery, Bob Langer has deeply impacted the field by quantitative analysis and innovative engineering. At the same time, he has inspired several generations of engineers by collaborations and mentorship. His scientific insights, innovative technologies, translational efforts and dedicated mentorship have transformed the field.

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“…However, clinical uses of LFS are relatively rare, with only a few current applications in patients because of the lack of historical precedence of safety. Examples of biological molecules delivered transcutaneously by the use of LFS are summarized in Table 22.3 [250].…”

Section: Ultrasound-mediated Transdermal Deliverymentioning

confidence: 99%

Routes of Delivery for Biological Drug Products

Irvine¹,

Su²,

Kwong³

2013

Pharmaceutical Sciences Encyclopedia

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Unlike conventional small‐molecule drugs, many of which can be formulated effectively with excipients to avoid degradation in the stomach and which exhibit reasonably efficient uptake through the gastrointestinal tract, biological drugs may exhibit lower stability and a greater sensitivity to enzymatic degradation, making oral delivery problematic. Thus, the majority of biologics are currently administered through subcutaneous/intramuscular injection or via intravenous infusion. Recent advances in delivery of traditional biologics include methods to increase the acceptable volume of drug solutions that can be administered subcutaneously.In addition, a number of alternative routes of administration for biologic drug products are being intensively investigated at the preclinical and clinical stages, such as intranasal, pulmonary, transcutaneous, and other routes, with some first examples of products recently licensed.This chapter will review current methods in use for marketed biologics and advanced approaches undergoing clinical testing.

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Low-frequency sonophoresis: application to the transdermal delivery of macromolecules and hydrophilic drugs

Cited by 149 publications

References 95 publications

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Engineering Approaches to Transdermal Drug Delivery: A Tribute to Contributions of Prof. Robert Langer

Routes of Delivery for Biological Drug Products

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