Low-frequency sonophoresis: Current status and future prospects

Ogura, Makoto; Paliwal, Sumit; Mitragotri, Samir

doi:10.1016/j.addr.2008.03.006

Cited by 159 publications

(93 citation statements)

References 58 publications

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“…The residue 6.1 kg was diluted with t-butyl methyl ether 18.3 kg , and filtered to remove the remaining erythritol. The filtrate was diluted again with t-butyl methyl ether 24 kg , washed twice with aqueous NaHCO 3 , and concentrated in vacuo at 100 . The product obtained 4.7 kg, 1 consisted of monoesters 36 , diesters 12 , and triesters 52 of erythritol and phytanylacetic acid the ratio was determined by GC analysis .…”

Section: Experimental Procedures 21 Materialsmentioning

confidence: 99%

Preparation and Evaluation of Liquid-Crystal Formulations with Skin-permeation-enhancing Abilities for Entrapped Drugs

et al. 2011

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Section: Experimental Procedures 21 Materialsmentioning

confidence: 99%

Preparation and Evaluation of Liquid-Crystal Formulations with Skin-permeation-enhancing Abilities for Entrapped Drugs

et al. 2011

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“…In that context, ultrasound exposure to skin at conditions used in this study has a history of clinical safety (25). In our experiments, no visual damage or inflammation in skin was observed for up to 48 h after the STAMP procedure.…”

Section: Discussionmentioning

confidence: 67%

One-step acquisition of functional biomolecules from tissues

Paliwal

Ogura

Mitragotri

2010

Proc. Natl. Acad. Sci. U.S.A.

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Direct determination of functional biomolecular chemistry of clinically relevant tissues in vivo is a challenging task. Current approaches, based on tissue retrieval by biopsy and subsequent solubilization, are limited in terms of accurate representation of tissue constituents, reproducibility, and retention of functionality of solubilized tissue biomolecules. Using a pool of known surfactants, we designed and screened a large combinatorial library of surfactant formulations, which led to the discovery of rare synergistic formulations that greatly enhance tissue solubilization as well as preserve bioactivity of solubilized molecules, in particular proteins. By combining these formulations with a short ultrasound application, we developed a tissue sampling method—STAMP ( S urfactant-based T issue A cquisition for M olecular P rofiling)—for rapid one-step determination of functional tissue chemistry in vivo. We specifically demonstrate STAMP-assisted profiling of a multitude of proteins, lipids, and genomic DNA in skin and mucosal tissues. Applications of this sampling methodology to rapid molecular diagnostics of cutaneous allergies and infectious diseases are also presented.

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“…In a world where needle reuse kills at least 1.3 million people per year from hepatitis B and AIDS, needle free, patch based vaccination could have large impact 48 . Excitement about this approach is exemplified by completion of phase 3 trials and submission for registration in Europe by Sanofi Pasteur (Paris) and Becton Dickinson for their micro needle based influenza vaccine 49 .…”

Section: Rising Interest In Transdermal Vaccinesmentioning

confidence: 99%

Transdermal Drug Delivery Adhesion as a Critical Parameter

Singh¹,

Sareen²

2013

Int. Res. J. Pharm.

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Transdermal drug delivery system (TDDS), also known as "patches", are the dosage forms designed to deliver a therapeutically effective amount of drug across a patient's skin. The adhesive of the transdermal drug delivery system is very crucial to the safety, efficacy and quality of the product. Recently, it has been recognized that the skin can also serve as the port of administration for systemically active drugs. The drugs applied topically are first absorbed into the blood stream and then are transported to the target tissues. Now, it is becoming evident that the benefits of intra venous infusion can be closely duplicated by using skin as the port of drug administration to provide continuous transdermal drug infusion into the systemic circulation. One of the objectives of TDDS is the maintenance of blood concentration of drug at therapeutic level by means of controlled permeation throughout the skin during a long period of time and using only one administration. The drug input can be terminated at any point of time by just removing the patch. Rate of drug release from the TDDS is normally much greater than the amount that the skin can possibly absorb. Hence, even if there is a variation in skin permeability, a constant rate of drug input into the circulation is achieved. This article provides an overview of type of transdermal systems, role of adhesion, possible adhesion failures and the measurement of adhesion. In vitro techniques like peel adhesion, tack and shear strength are discussed. Adhesion needs to be a critical parameter for designing a transdermal drug delivery system in order to provide good quality and efficacy to the patient. This review also covers a brief outline of various components of a patch, their advantages, when the patch should be used and when their use should be avoided.

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Low-frequency sonophoresis: Current status and future prospects

Cited by 159 publications

References 58 publications

Preparation and Evaluation of Liquid-Crystal Formulations with Skin-permeation-enhancing Abilities for Entrapped Drugs

Preparation and Evaluation of Liquid-Crystal Formulations with Skin-permeation-enhancing Abilities for Entrapped Drugs

One-step acquisition of functional biomolecules from tissues

Transdermal Drug Delivery Adhesion as a Critical Parameter

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