Low-frequency variability in photoplethysmography and autonomic function assessment

Allen, John; Chen, Fei

doi:10.1016/b978-0-12-823374-0.00008-6

Cited by 6 publications

(5 citation statements)

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“…This has included its use as a basis for a rapidly Frontiers in Physiology frontiersin.org expanding variety of wearable devices (Singh et al, 2021;Charlton and Vaidotas, 2022). The implementation of advanced methods of PPG signal processing, including advanced morphological analysis, has expanded the capabilities, accuracy, and usefulness of this technology in various fields of physiology and pathology such as cardiovascular function, sleep studies, pregnancy, pain, and mental health (Hickey et al, 2015;Qawqzeh et al, 2020;Ahmed et al, 2022;Allen, 2022;Allen and Fei, 2022;. Previously we found, using laser Doppler and thermal imaging, that PBM induces arteriolar vasodilatation resulting in both immediate and long-lasting increased capillary flow and tissue perfusion in healthy individuals, but not in participants having "cold hands" or "hot hands" (Gavish et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Advances in Basic and Applied Research in Photoplethysmography

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Section: Discussionmentioning

confidence: 99%

Advances in Basic and Applied Research in Photoplethysmography

2024

Frontiers Research Topics

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“…This has included its use as a basis for a rapidly expanding variety of wearable devices ( Singh et al, 2021 ; Charlton and Vaidotas, 2022 ). The implementation of advanced methods of PPG signal processing, including advanced morphological analysis, has expanded the capabilities, accuracy, and usefulness of this technology in various fields of physiology and pathology such as cardiovascular function, sleep studies, pregnancy, pain, and mental health ( Hickey et al, 2015 ; Qawqzeh et al, 2020 ; Ahmed et al, 2022 ; Allen, 2022 ; Allen and Fei, 2022 ; Mejia-Mejia et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

“…This has included its use as a basis for a rapidly Frontiers in Physiology frontiersin.org expanding variety of wearable devices (Singh et al, 2021;Charlton and Vaidotas, 2022). The implementation of advanced methods of PPG signal processing, including advanced morphological analysis, has expanded the capabilities, accuracy, and usefulness of this technology in various fields of physiology and pathology such as cardiovascular function, sleep studies, pregnancy, pain, and mental health (Hickey et al, 2015;Qawqzeh et al, 2020;Ahmed et al, 2022;Allen, 2022;Allen and Fei, 2022;Mejia-Mejia et al, 2022). Previously we found, using laser Doppler and thermal imaging, that PBM induces arteriolar vasodilatation resulting in both immediate and long-lasting increased capillary flow and tissue perfusion in healthy individuals, but not in participants having "cold hands" or "hot hands" (Gavish et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Morphological features of the photoplethysmographic signal: a new approach to characterize the microcirculatory response to photobiomodulation

Ovadia-Blechman,

Hauptman,

Rabin

et al. 2023

Front. Physiol.

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Introduction and Objectives: Advanced analysis of the morphological features of the photoplethysmographic (PPG) waveform may provide greater understanding of mechanisms of action of photobiomodulation (PBM). Photobiomodulation is a non-ionizing, red to near-infrared irradiation shown to induce peripheral vasodilatation, promote wound healing, and reduce pain. Using laser Doppler flowmetry combined with thermal imaging we found previously in a clinical study that PBM stimulates microcirculatory blood flow and that baseline palm skin temperature determines, at least in part, why some individuals respond favorably to PBM while others do not. “Responders” (n = 12) had a skin temperature range of 33°C–37.5°C, while “non-responders” (n = 8) had “cold” or “hot” skin temperature (<33°C or >37.5°C respectively). The continuous PPG signals recorded from the index fingers of both hands in the original clinical study were subjected to advanced post-acquisitional analysis in the current study, aiming to identify morphological features that may improve the accuracy of discrimination between potential responders and non-responders to PBM.Methods: The PPG signals were detrended by subtracting the lower envelope from the raw signal. The Root Mean Square (RMS) and Entropy features were extracted as were two additional morphological features -- Smoothness and number of local extrema per PPG beat (#Extrema). These describe the signal jaggedness and were developed specifically for this study. The Wilcoxon test was used for paired comparisons. Correlations were determined by the Spearman correlation test (rs).Results: The PPG waveforms of responders to PBM had increased amplitude and decreased jaggedness (Baseline vs. 10’ post-irradiation: Entropy, 5.0 ± 1.3 vs. 3.9 ± 1.1, p = 0.012; #Extrema, 4.0 ± 1.1 vs. 3.0 ± 1.6, p = 0.009; RMS, 1.6 ± 0.9 vs. 2.3 ± 1.2, p = 0.004; Smoothness, 0.10 ± 0.05 vs. 0.19 ± 0.16, p = 0.016). In addition, unilateral irradiation resulted in a bilateral response, although the response of the contralateral, non-irradiated hand was shorter in duration and lower in magnitude. Although subjects with ‘cold,’ or ‘hot,’ baseline skin temperature appeared to have morphologically distinct PPG waveforms, representing vasoconstriction and vasodilatation, these were not affected by PBM irradiation.Conclusion: This pilot study indicates that post-acquisitional analysis of morphological features of the PPG waveform provides new measures for the exploration of microcirculation responsiveness to PBM.

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“…The wider published literature for this important field in PPG research also includes publications on a range of potential autonomic function applications including the assessment of cardiovascular regulation, diabetic neuropathy, endothelial dysfunction, peripheral vascular impairment, sleep science, pain, falls and syncope (orthostatic hypotension, OH), mental health and wellbeing, and for unique and challenging environments such as micro-gravity/space and military research (figure 23 (B)) (Allen and Chen 2021 , Allen et al 2021 ). There are also PPG-based autonomic function testing devices on the market including semi-portable systems for measuring beat-to-beat BP and its variability for use in hospital autonomic function testing units and clinical research facilities (e.g.…”

Section: Ppg Low Frequency Variability and Autonomic Functionmentioning

confidence: 99%

The 2023 wearable photoplethysmography roadmap

Charlton¹,

Allen²,

Bailón³

et al. 2023

Physiol. Meas.

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Photoplethysmography is a key sensing technology which is used in wearable devices such as smartwatches and fitness trackers. Currently, photoplethysmography sensors are used to monitor physiological parameters including heart rate and heart rhythm, and to track activities like sleep and exercise. Yet, wearable photoplethysmography has potential to provide much more information on health and wellbeing, which could inform clinical decision making. This Roadmap outlines directions for research and development to realise the full potential of wearable photoplethysmography. Experts discuss key topics within the areas of sensor design, signal processing, clinical applications, and research directions. Their perspectives provide valuable guidance to researchers developing wearable photoplethysmography technology.

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Low-frequency variability in photoplethysmography and autonomic function assessment

Cited by 6 publications

References 140 publications

Advances in Basic and Applied Research in Photoplethysmography

Advances in Basic and Applied Research in Photoplethysmography

Morphological features of the photoplethysmographic signal: a new approach to characterize the microcirculatory response to photobiomodulation

The 2023 wearable photoplethysmography roadmap

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