Low Friction Hydrophilic Surface for Medical Devices

Abstract

A hydrophilic polymer surface with low friction has been developed. A coating can be attached by the reaction of an epoxy containing poly (vinyl pyrrolidone) with the polyamino compound formed on the surface of the substrate. The epoxy containing poly(vinyl pyrrolidone) was obtained by the copolymerization of vinyl pyrrolidone, glycidyl acrylate, and vinyl acetate. A molecular weight of 400,000 or more is essential to achieve low surface friction. Polyurethane catheters in rabbit models, both with and without the hydrophilic low friction coating, were evaluated for surface friction coefficient and blood compatibility. The coated catheters produced no lesions of the intima of the blood vessels and no thrombus formation on the catheter surface, while the non-coated catheters injured the intima of the blood vessels and severe thrombus formation was found on their surfaces.

Development and in Vitro Characterization of Photochemically Crosslinked Polyvinylpyrrolidone Coatings for Drug-Coated Balloons

“…Having in mind that many of these interventional cardiovascular devices already incorporate a hydrophilic lubricious coating in order to ease movement through the vasculature [13,14], the use of the same hydrophilic coating as drug reservoir and transfer agent would be of high interest for DCB. When exposed to aqueous environments, these lubricious coatings may absorb a multiple of times its dry weight in water.…”

In vitro evaluation of phosphonylated low‐density polyethylene for vascular applications

“…Many studies have examined the frictional behavior of catheter materials as a means to decrease intimal lesions of blood vessels and/or decrease thrombus formation on the surface of the catheters. 6,[13][14][15][16][17] Typical methods used to measure the friction include inclined plane apparatus, 13 pulley apparatus, 17 trust-collar apparatus, 14 in vitro and in vivo pull-out tests, 6,13,15 and atomic force microscopy. 16 Although many hydrophilic catheter surfaces have been studied, the effect of surface phosphonylation as a means to increase hydrophilicity and to aid in friction management has not previously been examined.…”

Elimination of stick-slip of elastomeric sutures by radiofrequency glow discharge deposited coatings

“…Graft hydrogel coatings have been used to reduce friction in biomedical applications, where the hydrogel adsorbs water from the surrounding tissue to act as a lubricant. [6][7][8] Alternatively, the deposition of thin polymeric coatings from vapors activated by radio-frequency glow discharge [12][13][14] offers several desirable features such as robust, covalent interfacial bonding between the substrate material and the rfgd coating, the use of coating materials that are chemically stable and inert, and ease of process control. The rfgd coating process is less damaging to vulnerable polymeric substrate materials than other high-energy surface modification methods.…”

“…2 The problem of overcoming frictional forces of a biomedical device surface is not confined to sutures; a number of studies have addressed the lubrication of catheters and other biomedical devices. [5][6][7][8][9][10] The simplest method for reducing friction is by the application of lubricating oils or polymers. 11 Lubricants are, however, noncovalently associated with the surface of the device and are easily stripped off, reducing their effectiveness.…”