Low glucose transporter SLC2A5-inhibited human normal adjacent lung adenocarcinoma cytoplasmic pro-B cell development mechanism network

You, Jingwen; Wang, Lin; Huang, Jianing; Jiang, Minghu; Chen, Qingchun; Wang, Yangming; Jiang, Ziyi

doi:10.1007/s11010-014-2233-x

Cited by 7 publications

(11 citation statements)

References 27 publications

(26 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Enrichment analysis revealed that SAC3D1 and 4 other SAC3D1-related genes (CDK1, CCNB1, CCNB2 and CDC20) are important for GC development via the cell cycle pathway. Numerous studies have reported the overexpression of SAC3D1 in several types of cancer, including hepatocellular carcinoma (11), colon cancer (12) and lung adenocarcinoma (13). Recent studies have assessed the prognostic value of SAC3D1 using GEO, the Cancer Genome Atlas and International Cancer Genome Consortium and suggested that SAC3D1 may be a credible prognosis-related biomarker for hepatocellular carcinoma (11).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Upregulated expression of SAC3D1 is associated with progression in gastric cancer

et al. 2020

View full text Add to dashboard Cite

SAC3 domain containing 1 (SAC3D1) has been reported to be involved in numerous types of cancer. However, the role of SAC3D1 in GC has not yet been elucidated. In the present study, the mRNA expression level of SAC3D1 between GC and normal tissues were assessed with a continuous variable meta-analysis based on multiple datasets from public databases. The protein expression level of SAC3D1 in GC and normal tissues was assessed by an in-house immunohistochemistry (IHC). The association between SAC3D1 expression and some clinical parameters was assessed based on the TCGA and IHC data. Survival analysis was performed to assess the association between SAC3D1 expression and the survival of GC patients. The co-expressed genes of SAC3D1 were determined by integrating three online tools, and the enrichment analyses were performed to determine SAC3D1-related pathways and hub co-expressed genes. SAC3D1 was significantly upregulated in GC tumor tissues in comparison to normal tissues with the SMD being 0.45 (0.12, 0.79). The IHC results also indicated that SAC3D1 protein expression in GC tissues was markedly higher than in normal tissues. The SMD following the addition of the IHC data was 0.59 (0.11, 1.07). The protein levels of SAC3D1 were positively associated with the histological grade, T stage and N stage of GC (P<0.001). The TCGA data also revealed that the SAC3D1 mRNA level was significantly associated with the N stage (P<0.001). Moreover, prognosis analysis indicated that SAC3D1 was closely associated with the prognosis of patients with GC. Moreover, 410 co-expressed genes of SAC3D1 were determined, and these genes were mainly enriched in the cell cycle. In total, 4 genes (CDK1, CCNB1, CCNB2 and CDC20) were considered key co-expressed genes. On the whole, these findings demonstrate that SAC3D1 is highly expressed in GC and may be associated with the progression of GC.

show abstract

Section: Discussionmentioning

confidence: 99%

“…The prognostic value of SAC3D1 has also been demonstrated in colon cancer (12). You et al reported that SAC3D1 was associated with SLC2A5-inhibited adjacent lung adenocarcinoma cytoplasmic pro-B cell progression (13). However, the role and molecular mechanisms of action of SAC3D1 in GC have not…”

Section: Introductionmentioning

confidence: 99%

Upregulated expression of SAC3D1 is associated with progression in gastric cancer

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The protein encoded by SLC2A5 is a fructose transporter responsible for fructose uptake,26 and the protein encoded by CACNA1D is the alpha-1D subunit of calcium channel 27. Enhanced growth and proliferation of tumor cells place increased demand for nutrients for the synthesis of DNA and protein 28.…”

Section: Discussionmentioning

confidence: 99%

Exploration of the molecular mechanism of prostate cancer based on mRNA and miRNA expression profiles

Zhang¹,

Sun²,

Wang³

et al. 2017

OTT

View full text Add to dashboard Cite

Prostate cancer, the second most common cancer in men, has been rarely explored by integrating mRNA and miRNA expression profiles. In this study, we combined two mRNA expression datasets and six documented miRNAs to uncover the comprehensive molecular mechanism of prostate cancer. Results showed that a total of 30 genes were significantly differentially expressed in 49 tumor samples by comparing with 22 normal samples. Importantly, all samples from the two datasets can be clearly classified into two groups, tumor group and normal group, based on the selected differentially expressed genes (DEGs). The miRNA–mRNA regulation network indicated that 4 out of 30 DEGs can be regulated by three miRNAs. In addition, prognostic performance validation using in silico databases showed that the DEGs can significantly differentiate between low-risk and high-risk prostate cancer. In summary, multiple biological processes are probably involved in the development and progression of prostate cancer. First, dysregulation of SV2 can regulate transporter and transmembrane transporter activity and then provide the necessary nutrients for tumor cell proliferation. Second, HOXD10 can induce cell proliferation via TCF-4. Finally, dysregulation of CACNA1D can further suppress tumor apoptosis in prostate cancer. The identification of critical genes and valuable biological processes can be useful for the understanding of the molecular mechanism of prostate cancer.

show abstract

“…Con, human normal adjacent tissues; Ex, lung adenocarcinoma; Act, activation Immunol Res out interactive inflammation immune-induced transcription-dependent apoptosis using SAM [7][8][9][10][11][12]. The GSE7670 raw microarray data were processed by log base 2, two classes were paired, and minimum fold change C2 selected (the false-discovery rate 0 %) [13][14][15][16].…”

Section: Methodsmentioning

confidence: 99%

“…Gene expression values of BIK-activatory different molecules were computed in low normal adjacent tissues compared with the corresponding high lung adenocarcinoma by AVERAGE and STDEV [13,14].…”

Section: Methodsmentioning

confidence: 99%

Low BIK outside-inside-out interactive inflammation immune-induced transcription-dependent apoptosis through FUT3-PMM2-SQSTM1-SFN-ZNF384

et al. 2015

Self Cite

View full text Add to dashboard Cite

Eighteen different Pearson mutual-positive-correlation BIK-activatory molecular feedback upstream and downstream networks were constructed from 79 overlapping of 376 GRNInfer and 98 Pearson under BIK CC ≥ 0.25 in low normal adjacent tissues of Taiwan compared with high lung adenocarcinoma. Our identified BIK interactive total feedback molecular network showed FUT3 [fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase Lewis blood group)], PMM2 (phosphomannomutase 2), SQSTM1 (sequestosome 1), SFN_2 [REX2 RNA exonuclease 2 homolog (S. cerevisiae)] and ZNF384 (zinc finger protein 384) in low normal adjacent tissues of lung adenocarcinoma. BIK interactive total feedback terms included mitochondrial envelope, endomembrane system, integral to membrane, Golgi apparatus, cytoplasm, nucleus, cytosol, intracellular signaling cascade, mitochondrion, extracellular space, inflammation, immune response, apoptosis, cell differentiation, cell cycle, regulation of cell cycle, cell proliferation, estrogen-responsive protein Efp controls cell cycle and breast tumors growth, induction or regulation of apoptosis based on integrative GO, KEGG, GenMAPP, BioCarta and disease databases in low normal adjacent tissues of lung adenocarcinoma. Therefore, we propose low BIK outside-inside-out interactive inflammation immune-induced transcription-dependent apoptosis through FUT3-PMM2-SQSTM1-SFN-ZNF384 in normal adjacent tissues of lung adenocarcinoma.

show abstract

Low glucose transporter SLC2A5-inhibited human normal adjacent lung adenocarcinoma cytoplasmic pro-B cell development mechanism network

Cited by 7 publications

References 27 publications

Upregulated expression of SAC3D1 is associated with progression in gastric cancer

Upregulated expression of SAC3D1 is associated with progression in gastric cancer

Exploration of the molecular mechanism of prostate cancer based on mRNA and miRNA expression profiles

Low BIK outside-inside-out interactive inflammation immune-induced transcription-dependent apoptosis through FUT3-PMM2-SQSTM1-SFN-ZNF384

Contact Info

Product

Resources

About