Low-Grade Adenosquamous Carcinoma of the Breast

Hoeven, K. H. Van; Drudis, Teresa; Cranor, Milicent L.; Erlandson, Robert A.; Rosen, Paul Peter

doi:10.1097/00000478-199303000-00005

Cited by 128 publications

(40 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, in a series of low-grade adenosquamous carcinoma, 3 of 32 cases were associated with adenomyoepithelioma as a distinct focal process. 13 In fact, it seems that both tumors are phenotypically related, being formed by a dual epimyoepithelial proliferation. 5 Another peculiar feature observed in the first case was the extensive amount of cells with foamy cytoplasm similar to macrophages in the background, suggesting a benign condition, in addition to the apocrine cells.…”

Section: Discussionmentioning

confidence: 99%

Adenomyoepithelioma of the breast: Report of two cases with prominent cystic changes and intranuclear inclusions

Laforga¹,

Aranda²,

Sevilla³

1998

Diagn. Cytopathol.

View full text Add to dashboard Cite

Adenomyoepithelioma is a rare breast tumor. Histologically it may disclose different patterns of growth, and some additional features may result in diagnostic errors. We describe 2 cases of adenomyoepithelioma of the breast initially examined by fine-needle aspiration biopsy (FNAB). Cytologic features included hypercellularity, clusters of epithelial and myoepithelial cells with occasional intranuclear inclusions, prominent apocrine metaplasia, and foam cells. Histologically, both tumors were diagnosed as adenomyoepithelioma tubular-variant, with prominent myoepithelial clear cells, apocrine metaplasia, and foci of squamous metaplasia. Immunohistochemically, the tumors showed strong positivity for keratins CAM 5.2, AE1/AE3, and EMA in the epithelial component, while the myoepithelial cells reacted with muscle-specific actin (A14 and HHF35) and S-100 protein. We point out that FNAB in this rare tumor may exhibit a varied spectrum of cells that may result in confusion with other lesions, and we call attention to the presence of intranuclear inclusions. The latter observation in the present cases by cytologic and histologic assessment provides an additional feature to the morphological characteristics of adenomyoepithelioma of the breast.

show abstract

Section: Discussionmentioning

confidence: 99%

Adenomyoepithelioma of the breast: Report of two cases with prominent cystic changes and intranuclear inclusions

Laforga¹,

Aranda²,

Sevilla³

1998

Diagn. Cytopathol.

View full text Add to dashboard Cite

show abstract

“…Additionally, Van Hoeven et al [10] observed that a significant number of LGASCs present in association with benign breast lesions (intraductal papillary lesions, adenomyoepitheliomas and collagenous spherulosis). In our series, LGASCs were rather associated with breast malignancies (lobular and ductal infiltrative carcinomas), which merits further studies and analyses.…”

Section: Discussionmentioning

confidence: 99%

Fine-Needle Aspiration of Low-Grade Adenosquamous Carcinomas of the Breast: A Report of Three New Cases

Bataillon

Collet²,

Voillemot³

et al. 2014

Acta Cytologica

View full text Add to dashboard Cite

Objectives: To describe cytology patterns in low-grade adenosquamous carcinomas (LGASCs) of the breast. Study Design: Low-grade adenosquamous carcinomas of the breast are a recently described rare variant of primary metaplastic carcinomas characterized by clinical indolence, slow evolution and excellent survival. To date, only 7 cases of LGASC were studied cytologically, and it was demonstrated that LGASC identification was difficult because its cellular components exhibited unspecific and nonsuspicious features. They consisted of irregularly clustered cells without prominent cytonuclear atypia, mitosis or necrosis. The presence of metaplastic cells or keratin debris was helpful in accurate tumor typing. We report here 3 additional cases of LGASC that were initially studied by fine-needle aspiration. Results: We have also encountered diagnostic difficulties and misdiagnosed tumors, since 2 cases were underdiagnosed as ‘suspicious' and only 1 was accurately diagnosed as malignancy. Conclusion: The review of our cases and the literature confirms that, despite its putative metaplastic origin, LGASC is an entity which is difficult to diagnose using classical cytological methods. Moreover, core-needle biopsy as well as frozen sections may also misdiagnose LGASC as a benign breast lesion.

show abstract

“…Complex sclerosing lesion with an adenosquamous proliferation are of uncertain nature but have been reported to be associated together [11]. This tumour is thought to carry only a minimal risk for metastatic progression but it carries a significant risk for local recurrence [12]. Therefore, complete local excision or mastectomy to achieve clear margins appear appropriate in light of the fact that there is paucity of long-term follow-up data in these patients.…”

Section: Discussionmentioning

confidence: 99%

Adenosquamous carcinoma of breast in a 19 years old woman: a case report

et al. 2010

View full text Add to dashboard Cite

BackgroundAdenosquamous carcinoma of the breast is a rare form of metaplastic breast carcinoma. We report such a case in a 19 years old female.Case presentationCase notes and histopathology were reviewed. Adenosquamous carcinoma was diagnosed on wide local excision and patient underwent skin-sparing mastectomy with Latissimus dorsi flap reconstruction.ConclusionsAdenosquamous carcinoma of the breast is a rare form of metaplastic breast carcinoma. Data on correct management, follow-up and prognosis are very limited but given the high potential for local recurrence, aggressive surgery may be the only option.

show abstract

Low-Grade Adenosquamous Carcinoma of the Breast

Cited by 128 publications

References 0 publications

Adenomyoepithelioma of the breast: Report of two cases with prominent cystic changes and intranuclear inclusions

Adenomyoepithelioma of the breast: Report of two cases with prominent cystic changes and intranuclear inclusions

Fine-Needle Aspiration of Low-Grade Adenosquamous Carcinomas of the Breast: A Report of Three New Cases

Adenosquamous carcinoma of breast in a 19 years old woman: a case report

Contact Info

Product

Resources

About