Low-Grade Astrocytoma within a Mature Cystic Teratoma in an Adolescent Patient

Yoder, Nicole; Marks, Asher; Hui, Pei; Litkouhi, Babak; Cron, Julia

doi:10.1016/j.jpag.2017.10.005

Cited by 9 publications

(8 citation statements)

References 9 publications

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“…cPNETs arise in the presence of central nervous tissue, and are thought to stem from a teratoma, although scientific articles have described the conjunction between cPNET and endometrioid carcinoma or mixed malignant mesodermal tumor [ 3 , 19 ]. The differentiated variant of cPNET can resemble either an ependymoma or a neurocytoma, an oligodendroglioma or an astrocytoma [ 20 , 21 , 22 , 23 , 24 ]. The primitive variant of cPNET, as the name implies, features the most primitive histological aspect of a neuroectodermal tumor and frequently resembles a medulloblastoma, neuroblastoma, medulloepithelioma or ependymoblastoma [ 3 ].…”

Section: ⧉ Discussionmentioning

confidence: 99%

Peripheral-type primitive neuroectodermal tumor of the ovary with EWSR1–FLI1 fusion transcript: a case report and brief review of literature

Grigoriu

Terzea²,

Lisievici³

et al. 2022

Rom J Morphol Embryol

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Primitive neuroectodermal tumors (PNETs) of the ovary are extremely rare tumors composed of undifferentiated small cells with round nuclei and scant cytoplasm. They are rare in general and extremely rare in the female gynecological tract, where they most commonly affect the ovary, followed by the uterine corpus. The most common presenting symptoms are abdominal pain, bloating and the presence of a pelvic mass. Diagnosis mainly relies on immunohistochemical and fluorescence in situ hybridization (FISH). Due to the rarity of these tumors, there are no standard therapeutic guidelines and treatment consists of surgery, various chemotherapy regimens and/or radiotherapy. In this article, we report the case of a 30-year-old female with peripheral-type PNET (pPNET) of the ovary featuring Ewing sarcoma breakpoint region 1-Friend leukemia integration 1 (EWSR1-FLI1) fusion transcript, confirmed by next-generation sequencing (NGS).

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Section: ⧉ Discussionmentioning

confidence: 99%

Peripheral-type primitive neuroectodermal tumor of the ovary with EWSR1–FLI1 fusion transcript: a case report and brief review of literature

Grigoriu

Terzea²,

Lisievici³

et al. 2022

Rom J Morphol Embryol

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“…Whereas neural tissue is found in approximately 80% of mature cystic teratomas, malignant transformation of neuroectodermal tissue is an exceptional event with few cases reported in the literature (11,12). All these experienced an excellent prognosis after surgical resection alone.…”

Section: Discussionmentioning

confidence: 99%

“…These ovarian germ cell tumors undergo malignant transformation in approximately 2% of the cases, and squamous cell carcinoma is the most commonly associated cancer (1,3,4). Less frequently encountered neoplasias are represented by mucinous carcinomas (5,6), thyroid carcinomas (3,(5)(6)(7)(8)(9), carcinoids (5,10), neuroectodermal tumors (11,12) and sarcomas (13).…”

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confidence: 99%

Clinical Outcome of Patients With Malignant Tumors Associated With Mature Cystic Teratomas of the Ovary: A Retrospective Multicenter Italian Study

et al. 2019

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Background/Aim: The aim of the study was to assess the clinical outcome of patients with malignant transformation of an ovarian mature teratoma. Patients and Methods: This study was conducted on 23 patients who underwent primary surgery at three Italian Gynecological Centers. Histologically, nine (39.1%) patients had squamous cell carcinoma, five (21.7%) had a thyroid carcinoma, six (26.1%) had a carcinoid, one (4.3%) patient had papillary renal carcinoma, one (4.3%) had medulloblastoma and one (4.3%) had intestinal-type mucinous adenocarcinoma. Results: All six patients with stage I squamous cell carcinoma had no evidence of disease (NED) after a median time of 141 months. Of the three patients with stage IIb-IIIc squamous cell carcinoma, two had NED after 119 and 154 months, and one died of the disease 9 months after diagnosis. All five women with stage I thyroid carcinoma had NED after a median of 60 months. Of the six patients with stage I carcinoid, five had NED after a median of 168 months, whereas one died due to carcinoid heart disease. The three patients with stage I renal carcinoma, medulloblastoma and mucinous adenocarcinoma had NED after 24, 141 and 149 months, respectively. Conclusion: The clinical outcome of early-stage malignancies associated with mature ovarian teratomas is excellent following treatment.

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“…10, Carcinomas can arise from any mature epithelial tissue. Adenosquamous carcinoma 13,14 Anaplastic Carcinoma 15 Angiosarcoma 16,17 Atypical compound nevus 18 BRAF-wild type PTEN mutant uveal malignant melanoma 19 Carcinoid tumor [20][21][22] Carcinosarcoma 23 Chordoma 24 Dedifferentiated chondrosarcoma 25 Fibrosarcoma 26 Follicular lymphoma 27 Follicular variant of papillary thyroid carcinoma 28 Ganglioneuroblastoma 29 Glioblastoma multiforme 30 Granular cell tumor 31 High-grade B-cell non-Hodgkin lymphoma 32 Large cell neuroendocrine carcinoma 33 Leiomyosarcoma 34 Low-grade astrocytoma 35 Malignant melanoma 10,36 Mucoepidermoid carcinoma 37,38 Multifocal carcinoma arising in struma ovarii 21 Oligodendroglioma/oligodendroglial cell proliferation 20,39 Ovarian clear cell adenocarcinoma 40 Ovarian mucinous cystadenocarcinoma 41 Papillary thyroid carcinoma 20,42 Poorly differentiated adenocarcinoma 43 Primary apocrine adenocarcinoma 44 Primary primitive neuroectodermal tumor 45 Prostate-type adenocarcinoma 46 Rhabdomyosarcoma 47 Sarcomatoid squamous cell carcinoma 48 Sebaceous carcinoma 21,49,…”

Section: Histopathologymentioning

confidence: 99%

“…Less frequent histologic types include adenocarcinoma, sarcomas, thyroid carcinoma, malignant melanoma, and neuroectodermal tumors, among others (Table 1). 10,13–56 Carcinomas can arise from any mature epithelial tissue. Squamous cell carcinoma in mature cystic teratoma arises from the epidermal component via a carcinoma in situ pathway, or from the respiratory epithelium via squamous metaplasia/dysplasia/carcinoma in situ pathway 2,7,11 .…”

Section: Histopathologymentioning

confidence: 99%

Malignant transformation of mature cystic teratoma of the ovary

Atwi

Kamal

Quinton

et al. 2022

J of Obstet and Gynaecol

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Mature cystic teratoma is the most common ovarian germ cell neoplasm. Malignant transformation is a rare occurrence, accounting for 1.5%–2% of cases. Malignant changes can arise from any constituent tissue of a teratoma; however, squamous cell carcinoma is the most common histologic type seen, followed by adenocarcinoma and sarcoma respectively. Tumor marker concentration levels, age, and the tumor maximum diameter are predictive indicators for malignant transformation. Proper diagnosis includes recognizing the possibility of malignant transformation versus excluding other differential options, such as metastasis. Primary cytoreductive surgery, adjuvant chemotherapy, and radiotherapy are the current treatment methods. The aim of the review is to discuss the clinical and pathologic features of malignant transformation within mature cystic teratomas, while reviewing the reported malignant types, differential diagnoses, and treatment options. Data sources include review of pertinent peer‐reviewed literature on malignant transformation of mature cystic teratoma and cases seen in authors' institutional practice. Mature cystic teratomas are a commonly encountered benign ovarian tumor. However, the possibility of malignant transformation should remain in consideration, especially with given clinical or pathologic features: increased patient age, tumor size, or tumor marker levels. Thorough sampling of solid tumor foci can help identify malignant components. Awareness and proper diagnosis, along with early detection and clinical management, shows improved patient outcomes.

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Low-Grade Astrocytoma within a Mature Cystic Teratoma in an Adolescent Patient

Cited by 9 publications

References 9 publications

Peripheral-type primitive neuroectodermal tumor of the ovary with EWSR1–FLI1 fusion transcript: a case report and brief review of literature

Peripheral-type primitive neuroectodermal tumor of the ovary with EWSR1–FLI1 fusion transcript: a case report and brief review of literature

Clinical Outcome of Patients With Malignant Tumors Associated With Mature Cystic Teratomas of the Ovary: A Retrospective Multicenter Italian Study

Malignant transformation of mature cystic teratoma of the ovary

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