2017
DOI: 10.2147/ott.s142818
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Low-grade central osteosarcoma in proximal humerus: a rare entity

Abstract: Low-grade central osteosarcoma is a rare subtype of tumor with low-grade malignancy. Currently, wide resection with negative resection margin is the standard treatment for this disease. The role of neoadjuvant chemotherapy in low-grade central osteosarcoma was controversial and was mostly considered for tumors containing high-grade focal areas. Local tumor recurrences often exhibited a tumor with higher histologic grade or differentiation with the potential for metastases. In low-grade central osteosarcoma, ti… Show more

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Cited by 2 publications
(1 citation statement)
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“…This type of bone osteosarcoma was rst described by Unni et al in 1977 3,4 , and later the World Health Organization described it as low-grade central osteosarcoma (LGCOS) 5 . Unlike most osteosarcomas, LGCOS is less aggressive with limited metastatic potential and a good prognosis 4,6 . Nonetheless, the tumor may recur locally to exhibit greater malignancy with an increased potential for metastasis 7,8 , and the current standard treatment modality for LGCOS is wide resection with a negative margin.…”
Section: Introductionmentioning
confidence: 99%
“…This type of bone osteosarcoma was rst described by Unni et al in 1977 3,4 , and later the World Health Organization described it as low-grade central osteosarcoma (LGCOS) 5 . Unlike most osteosarcomas, LGCOS is less aggressive with limited metastatic potential and a good prognosis 4,6 . Nonetheless, the tumor may recur locally to exhibit greater malignancy with an increased potential for metastasis 7,8 , and the current standard treatment modality for LGCOS is wide resection with a negative margin.…”
Section: Introductionmentioning
confidence: 99%