Low-grade fibromyxoid sarcoma: Clinical, morphologic and genetic features

Mohamed, Mustafa; Fisher, Cyril; Thway, Khin

doi:10.1016/j.anndiagpath.2017.04.001

Cited by 84 publications

(142 citation statements)

References 91 publications

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“…In this situation, the main tumor to consider in the differential diagnosis is HSCT. HSCT with giant rosettes is considered as a variant of LGFS as they share some histopathological features, immunoreactivity for MUC4 and the same balanced translocation FUS‐CREB3L2 . Both NLS and HSCT may show a spindle cell component between giant rosettes.…”

Section: Discussionmentioning

confidence: 99%

“…HSCT with giant rosettes is considered as a variant of LGFS as they share some histopathological features, 21,25 immunoreactivity for MUC4 and the same balanced translocation FUS-CREB3L2. 26,27 Both NLS and HSCT may show a spindle cell component between giant rosettes. Because of this common morphology, an overlap is detected in some relatively old reported cases 20,21 describing HSCT with S100 expression.…”

Section: Case Reportmentioning

confidence: 99%

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Neuroblastoma‐like schwannoma with giant rosette: A potential diagnostic pitfall for hyalinizing spindle cell tumor

et al. 2019

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Neuroblastoma‐like schwannoma (NLS) is a rare variant of a common tumor. The aim of this study is to discuss, through a literature review, the differential diagnoses of NLS while emphasizing the importance of ancillary studies. So far, 24 cases have been reported. We describe an additional case in a 64‐year‐old woman who had a 3‐cm subcutaneous tumor on her flank. The histological examination showed an encapsulated neoplasm. Most of the tumor was made of giant rosettes. These rosettes had several sizes reaching 2.6 mm. They showed a palisade of rounded cells. Nuclei were hyperchromatic but bland. The center was made of eosinophilic cores of collagenous radiating fibrils. Neoplastic cells stained strongly for S‐100 protein. In the capsule, perineural cells stained for epithelial membrane antigen (EMA). No expression of Mucin 4 (MUC4) was present. This was consistent with NLS. The same peculiar appearance of giant rosettes has been described in hyalinizing spindle cell tumor with giant rosettes (HSCT). We propose the term “neuroblastoma‐like schwannoma” when there are small rosettes, “HSCT‐like schwannoma” for tumors with giant rosettes and “collagen‐rich schwannoma” when there are “ill‐defined” structures reminiscent of rosettes. Immunohistochemical panel containing S100, EMA, and MUC4, as well as molecular testing when needed should be performed.

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Section: Discussionmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

Neuroblastoma‐like schwannoma with giant rosette: A potential diagnostic pitfall for hyalinizing spindle cell tumor

et al. 2019

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“…In contrast to MMM, the spindled cells of LGFMS are usually bland and uniform. Immunohistochemistry can be helpful in distinguishing LGFMS from MMM; LGFMS is positive for MUC4 and EMA, but is typically S‐100 negative . Molecular studies will reveal either a t(7;16)(q33;p11) or supernumerary ring chromosome, both of which result in a FUS‐CREB3L2 gene fusion in the majority of cases .…”

Section: Discussionmentioning

confidence: 99%

“…LGFMS is positive for MUC4 and EMA, but is typically S-100 negative. 24 Molecular studies will reveal either a t(7;16)(q33;p11) or supernumerary ring chromosome, both of which result in a FUS-CREB3L2 gene fusion in the majority of cases. 13 Additionally, the clinical presentation of LGFMS is distinct from MMM.…”

Section: Case Reportmentioning

confidence: 99%

Fine needle aspiration of malignant melanoma with myxoid features: A case report with molecular analysis

Felty

Jackson

Marotti

et al. 2019

Diagnostic Cytopathology

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Malignant melanoma with myxoid features (MMM) is a rare melanoma variant in which tumor cells are embedded within a basophilic myxoid stroma. The stromal matrix is composed of acidic mucopolysaccharides, which are thought to be produced by mesenchymal stromal cells in response to melanoma invasion. Interestingly, this myxoid matrix is more often seen in metastasis from a primary tumor that does not have a myxoid stroma. The diagnosis of MMM on fine needle aspiration (FNA) can be confused with other myxoid tumors. Herein, we present a case of MMM diagnosed by FNA of a peri‐auricular lymph node in an 89‐year‐old man with a history of resected malignant melanoma. We describe the clinical, cytohistological, and immunohistochemical findings, and present the unique molecular alterations that were identified. We also discuss the differential diagnosis and potential diagnostic pitfalls associated with MMM.

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“…Special MRI and CT finding for LGFMS are defined, although imaging findings are nonspecific [3,[8][9][10]. On CT images without contrast, the fibrous structure of these tumors interprete data density of muscular tissue, and the myxoid part was evaluated as hypodense.…”

Section: Discussionmentioning

confidence: 99%

Low-grade fibromyxoid sarcoma: a rare condition with high proliferation

Khezri

Taşkapılıoğlu

Türkkan

et al. 2018

The European Research Journal

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Low-grade fibromyxoid sarcoma (LGFMS) is a type of high metastatic potential of the fibrosarcomas. Most of the time there is a long interval between tumor presentation and metastasis. We present 2 cases of LGFMS. The first is a 31-year-old female with a mass in anterior aspect of her left thigh, and the other is a 68-year-old female with mass in posterior of her neck. Both cases underwent operation for several times and confirmed as LGFMS histopathologically, there is no exact protocol for postoperative follow-up to detect early metastases according to the relative variety of LGFMS. So informing the patients about the long-standing metastatic potential of their disease is important. Eur Res J 2018;4(3):238-241

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Low-grade fibromyxoid sarcoma: Clinical, morphologic and genetic features

Cited by 84 publications

References 91 publications

Neuroblastoma‐like schwannoma with giant rosette: A potential diagnostic pitfall for hyalinizing spindle cell tumor

Neuroblastoma‐like schwannoma with giant rosette: A potential diagnostic pitfall for hyalinizing spindle cell tumor

Fine needle aspiration of malignant melanoma with myxoid features: A case report with molecular analysis

Low-grade fibromyxoid sarcoma: a rare condition with high proliferation

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