Low-grade MALT lymphoma involving multiple mucosal sites and bone marrow

Abstract

Mucosa-associated lymphoid tissue (MALT) lymphomas are indolent neoplasms which tend to remain localized for a long time before spreading. We describe here the case of a 36-year-old woman with a low-grade MALT lymphoma involving the lung, stomach, lingual tonsil, and bone marrow at the time of diagnosis. The clonal origin of the pulmonary and bone marrow neoplastic infiltrates was assessed by means of gene rearrangement analysis. All of the involved sites were infiltrated by centrocyte- and monocytoid-like cells expressing the B-cell-associated antigens CD19 and CD20 and showed IgM lambda chain restriction; no CD5, CD10, or CD43 expression was detectable. As the patient had a history of recurrent bronchitis, and computed tomography performed 3 years before the lymphoma diagnosis had already revealed a lesion of the left lung, we conclude that the present case probably represents a pulmonary low-grade MALT lymphoma characterized by an early and unusual involvement of different mucosal sites and bone marrow.

Characteristics of gastric B-cell lymphoma of mucosa-associated lymphoid tissue type involving multiple organs

“…13,[15][16][17]19,[27][28][29] Yoshino et al 30 reported that only 7 (2.3%) of 304 gastric MALT lymphomas had multiorgan involvement. On the other hand, Thieblemont et al 20 reported that 14.8% (9/61) of gastric MALT lymphoma patients had disseminated disease.…”

Early-Stage Gastric MALT Lymphoma: Is It a Truly Localized Disease?

“…However, those investigators did not further compare circulating and gastric clones [36]. Other investigators have compared clones in MALT lymphomas between two or more different sites, such as the spleen and stomach, stomach and blood, multiple mucosal sites, and bone marrow, and found the same infiltrating clone [37][38][39][40]. However, these cases did not represent localized MALT lymphomas.…”

Extranodal marginal zone lymphoma of MALT involving the lungs, the stomach, and the colon

“…Thieblemont et al reported that out of 158 patients with MALT lymphomas only 18 (11%) had multiple organ localization, 7 (3.5%) of which had stomach and intestinal tract involvement, and 5 (3%) of which had GI tract and lung involvement [5]. Graziadei et al reported a case of MALT lymphoma involving the lungs, the stomach, the lingual tonsils, and the bone marrow at the time of diagnosis [9]. The International Extranodal Lymphoma Study Group reported that out of 180 patients with non-gastric lymphoma only 24 (13%) had involvement of multiple mucosal sites [10].…”