Low-grade salivary duct carcinoma of the parotid gland: report of a case with immunohistochemical analysis

Kusafuka, Kimihide; Itoh, Hideaki; Sugiyama, Chiho; Nakajima, Takashi

doi:10.1007/s00795-009-0479-2

Cited by 23 publications

(17 citation statements)

References 20 publications

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“…It is not even clear to this author that all the reported cases are even related to eachother. Some are distinctly apocrine and these cases stain for AR and BRST-2 and are often S100 negative [4,6,8,15]. Others are non-apocrine and these cases are generally negative for AR and always S100 positive [2,3,7].…”

Section: Discussionmentioning

confidence: 99%

Intraductal Carcinoma of Salivary Gland (So-Called Low-Grade Cribriform Cystadenocarcinoma) Arising in an Intraparotid Lymph Node

Weinreb

2011

Head and Neck Pathol

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Since the first description of an entirely intraductal epithelial proliferation of salivary gland by Chen in 1983 as an ''intraductal carcinoma'', there have been several dozen reported cases with the same and various additional names including ''low-grade salivary duct carcinoma'', ''low-grade cribriform cystadenocarcinoma'' and ''carcinoma in situ'' of salivary gland. These refer to a combination of nests and cysts of varying size formed by a cellular proliferation resembling atypical ductal hyperplasia or ductal carcinoma in situ of the breast. The lesions are generally entirely intraductal with low, intermediate or high-grade dysplasia. Occasional benign tumors of salivary gland, particularly Warthin tumor and rare salivary carcinomas may arise within an intraparotid lymph node. In addition, intraparotid lymph nodes are a routine location for metastatic disease. A case of a 59-year-old female with a parotid mass is described, which grossly had the appearance of a Warthin tumor. Microscopically, it was an entirely intranodal proliferation of cells with diffuse AE1/ AE3 and S100 positivity. The nests and cysts were completely surrounded by a rim of non-neoplastic myoepithelial cells, which were positive for CK14, p63, SMA, MSA and calponin. The tumor cells were negative for these markers. The cells were only focally positive for AR and BRST-2. They showed negligible MIB-1 staining. This report describes, for the first time, an entirely intranodal location for a low-grade intraductal carcinoma (so-called low-grade cribriform cystadenocarcinoma).

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Section: Discussionmentioning

confidence: 99%

Intraductal Carcinoma of Salivary Gland (So-Called Low-Grade Cribriform Cystadenocarcinoma) Arising in an Intraparotid Lymph Node

Weinreb

2011

Head and Neck Pathol

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“…LG-SDC is an exceedingly rare neoplasm with approximately 39 cases published in the English literature since 1996 [1,[3][4][5][6][7][8][9][10][11][12][13].…”

Section: Clinical Featuresmentioning

confidence: 99%

“…The ducts and lobules are occupied by a relatively monotonous ductal forming round spaces along with irregular fenestrated secondary lumina. Apocrine metaplasia can be observed in the lower left corner has been noted in 5 of 8 cases [4,5,9,14]. Occasionally, the luminal tumor cells have been positive for GCDFP-15, especially in areas with apocrine metaplasia [5,9,14].…”

Section: Immunohistochemistrymentioning

confidence: 99%

Low-Grade Salivary Duct Carcinoma or Low-Grade Intraductal Carcinoma? Review of the Literature

Kuo¹,

Weinreb²,

Perez-Ordonez³

2013

Head and Neck Pathol

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Low-grade salivary duct carcinoma (LG-SDC) is a rare neoplasm characterized by predominant intraductal growth, luminal ductal phenotype, bland microscopic features, and favorable clinical behavior with an appearance reminiscent of florid to atypical ductal hyperplasia to low grade intraductal breast carcinoma. LG-SDC is composed of multiple cysts, cribriform architecture with ''Roman Bridges'', ''pseudocribriform'' proliferations with floppy fenestrations or irregular slits, micropapillae with epithelial tufts, fibrovascular cores, and solid areas. Most of the tumor cells are small to medium sized with pale eosinophilic cytoplasm, and round to oval nuclei, which may contain finely dispersed or dark condensed chromatin. Foci of intermediate to high grade atypia, and invasive carcinoma or micro-invasion have been reported in up to 23 % of cases. The neoplastic cells have a ductal phenotype with coexpression of keratins and S100 protein and are surrounded by a layer of myoepithelial cells in noninvasive cases. The main differential diagnosis of LG-SDC includes cystadenoma, cystadenocarcinoma, sclerosing polycystic adenosis, salivary duct carcinoma in situ/highgrade intraductal carcinoma, and papillary-cystic variant of acinic cell carcinoma. There is no published data supporting the continuous classification of LG-SDC as a variant of cystadenocarcinoma. Given that most LG-SDC are noninvasive neoplasms; the terms ''cribriform cystadenocarcinoma'' and LG-SDC should be replaced by ''low-grade intraductal carcinoma'' (LG-IDC) of salivary gland or ''lowgrade intraductal carcinoma with areas of invasive carcinoma'' in those cases with evidence of invasive carcinoma.

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“…To date, there have been 12 published studies reporting a total of 39 cases of LGCCC (2)(3)(4)(5)(7)(8)(9)(10)(11)(12)(13)(14). Characteristics of the reported cases together with the present case are summarized in Table I.…”

Section: Discussionmentioning

confidence: 95%

Low-grade cribriform cystadenocarcinoma of the palatal gland: A case report

et al. 2015

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Abstract. Low-grade cribriform cystadenocarcinoma (LGCCC) is a malignant salivary gland tumor.LGCCC occurs rarely, with the parotid gland being the most commonly afflicted site. Few cases arise in other sites. The present study reports a case of LGCCC that occurred at the palatal gland of the hard palate. A 56-year-old female was referred to Saitama Medical University Hospital (Moroyama, Saitama, Japan) due to an intraoral mass. Since cytological examination and biopsy led to a diagnosis favoring a neoplasm, but with uncertain malignant potential, the tumor was resected with a safe surgical margin. The specimen was thoroughly examined. Microscopically, there was a well-demarcated, unilocular cyst with the lumen lined by tumor cells. The tumor cells were arranged in tubular, cribriform and solid structures in the area of the intracystic mass lesions. Nuclear atypia was inconspicuous, although mitotic figures were observed throughout the tumor. Neither local nor perineural invasion was present. On immunohistochemistry, the tumor cells were diffusely positive for S-100 protein. Myoepithelial markers, calponin and p63, highlighted the cells rimming the cystic mass. The final histopathological diagnosis was of LGCCC. The tumor was completely resected. At 1 year post-resection, the patient exhibited no recurrence or distant metastasis.LGCCC is regarded as clinically indolent. However, there is little literature available to aid with prognosis prediction due to the rarity of LGCCC cases. Thus, greater experience and longer follow-up periods are necessary to find the optimal/curative treatment for patients with LGCCC and to clarify the pathophysiology. IntroductionSalivary gland tumors produce a variety of histological patterns making tumor classification difficult (1).Low-grade cribriform cystadenocarcinoma (LGCCC) is a malignant salivary gland originally reported as a variant of salivary duct carcinoma (2). However, LGCCC differs from typical salivary duct carcinomas with respect to the growth pattern, a lack of evident nuclear atypia, invasiveness to the surrounding tissues, and regional lymph node metastasis (2,3). Thus, the 2005 World Health Organization classification considers this neoplasm to be a variant of cystadenocarcinoma, mainly due to its cystic morphology, since no definite association has been found between salivary duct carcinoma and LGCCC (1). In this classification system, LGCCC is defined by its histological similarity to breast atypical ductal hyperplasia or low-grade ductal carcinoma in situ (1).LGCCC is extremely rare and thus, the incidence rate of LGCCC remains unknown. The parotid gland is the most commonly involved site. Few cases arise at other sites, such as the submandibular gland and palate (2-7). The present study reports a case of LGCCC that occurred at the palatal gland of the hard palate. Written informed consent was obtained from the patient. Case reportA 56-year-old female was referred to Saitama Medical University Hospital (Moroyama, Saitama, Japan) from a local dentist in July 201...

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Low-grade salivary duct carcinoma of the parotid gland: report of a case with immunohistochemical analysis

Cited by 23 publications

References 20 publications

Intraductal Carcinoma of Salivary Gland (So-Called Low-Grade Cribriform Cystadenocarcinoma) Arising in an Intraparotid Lymph Node

Intraductal Carcinoma of Salivary Gland (So-Called Low-Grade Cribriform Cystadenocarcinoma) Arising in an Intraparotid Lymph Node

Low-Grade Salivary Duct Carcinoma or Low-Grade Intraductal Carcinoma? Review of the Literature

Low-grade cribriform cystadenocarcinoma of the palatal gland: A case report

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