Low-grade serous carcinoma of the ovary: A case series and literature review

Abstract

Introduction:Low-grade serous ovarian cancer is a rare subtype of epithelial ovarian cancer that is generally resistant to cytotoxic chemotherapy. We present a case series of patients diagnosed with low-grade serous ovarian carcinoma and review of the literature. Serous carcinoma represents the most common histologic subtype of epithelial ovarian cancer. Low-grade serous carcinoma of the ovary may occur de novo or following a diagnosis of serous tumor of low malignant potential. The primary modality of treatment for these patients is surgery. For patients with stage II-IV low-grade serous carcinoma, the standard is maximum cytoreductive surgery, with the goal of achieving minimal residual disease, followed by chemotherapy. Although lowgrade serous carcinoma of the ovary carries a relatively good prognosis, over 80% of patients will experience disease recurrence. Case Series: We report four cases of patients ages 31-58, with a diagnosis of low-grade serous ovarian cancer. Our patients were treated with cytoreductive surgery, chemotherapy and hormonal therapy. Two of our patients were also enrolled in a MEK inhibitor clinical trial. We describe in detail the clinical course of each patient and provide