Low HDL Cholesterol Levels

Ashen, M. Dominique; Blumenthal, R. S.

doi:10.1016/j.accreview.2005.11.021

Cited by 39 publications

(48 citation statements)

References 1 publication

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“…Piskorz [51], showed that elevated values of total cholesterol increased the risk of LVH signi icantly. Other studies have stated the direct association between elevated values of total cholesterol and the probability of cardiovascular diseases and LVH [33,52,53]. Although these results coincide with the eons obtained in the present series, it should be pointed out that in the latter was found a greater association with the risk of developing hypertensive cardiopathy, probably as a result of the cutpoints used that allowed a greater sensitivity and speci icity to this variable.…”

Section: Discussioncontrasting

confidence: 54%

Non-hemodynamic factors associated to the risk of developing hypertensive cardiopathy

Álvarez-Aliaga¹

2017

J Cardiol Cardiovasc Med

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Section: Discussioncontrasting

confidence: 54%

Non-hemodynamic factors associated to the risk of developing hypertensive cardiopathy

Álvarez-Aliaga¹

2017

J Cardiol Cardiovasc Med

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“…Lifestyle therapy to lower TGs and/or increase HDL-C: For patients with hypertriglyceridemia, intensify dietary therapy and exercise, with a focus on weight loss, restriction of refined carbohydrates and alcohol, and an increase in the intake of omega-3 fatty acids. For patients with low levels of HDL-C, increased aerobic exercise, increased intake of monounsaturated fats, moderate alcohol intake (if TGs are not significantly elevated), weight loss and smoking cessation are beneficial (reviewed in [122]). Increased statin dose: For patients with low HDL-C levels or mild hypertriglyceridemia, the recommended TC/HDL-C ratio may often be achieved by a further increase in statin dose, even if the target LDL-C level has been reached.…”

Section: Achievement Of the Target Tc/hdl-c Ratiomentioning

confidence: 99%

Canadian Cardiovascular Society position statement – Recommendations for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease

McPherson

Fröhlich

Fodor

et al. 2006

Canadian Journal of Cardiology

268

203

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“…In such subjects, low levels of plasma HDL-C are considered to be the factor most strongly promoting atherosclerosis development 26) . For example, among subjects with LDL-C levels below 70 mg/ dL in response to statin therapy, those in the highest quintile of HDL-C level had a lower risk of major cardiovascular events than those in the lowest quintile 27) .…”

Section: Correlations Of the Baseline Values Of Ldl-c (Panel A) Hdl-mentioning

confidence: 99%

Elevation of HDL-C in Response to Statin Treatment is Involved in the Regression of Carotid Atherosclerosis

Ishigaki¹,

Kono²,

Katagiri³

et al. 2014

JAT

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Aim: Atherosclerosis is strongly associated with an increased mortality in subjects with diabetes. The carotid intima-media thickness (IMT) is commonly measured as a surrogate marker for cardiovascular risk. Statins are well-established protective agents against atherosclerosis and reportedly suppress IMT progression in subjects with diabetes. To clarify the effects of statins on subclinical atherosclerosis, we herein investigated changes in the carotid IMT and lipid profiles in a multi-center, prospective, randomized trial. Methods: Hypercholesterolemic subjects with type 2 diabetes were randomly assigned to open-label treatment with either pravastatin or pitavastatin. The primary endpoint of this study was the IMT change after 36 months of statin treatment. Results: A total of 97 subjects (51 pitavastatin; 46 pravastatin) completed this 36-month study. The LDL-C decreased significantly from 163.4±27.9 mg/dl at baseline to 100.4±19.6 mg/dl at 36 months in the pitavastatin group and from 159.7±25.6 mg/dl to 118.5±22.1 mg/dl in the pravastatin group. The mean IMT showed moderate regression in both the pitavastatin (−0.070±0.215 mm, P＜0.05) and the pravastatin (−0.067±0.260 mm) group. However, there was no significant difference in the IMT change between the two groups. When the two groups were combined, the 36-month change in the mean IMT was significantly associated with HDL-C change (r= −0.24, P= 0.03). Multiple linear regression analysis revealed the change in HDL-C to be an independent variable showing a positive correlation with the carotid IMT reduction. Conclusion: The administration of statins for 3 years to subjects with type 2 diabetes resulted in a significant regression of the carotid IMT. An elevation of the plasma HDL-C with statin treatment was closely related to a regression of atherosclerosis.

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Low HDL Cholesterol Levels

Cited by 39 publications

References 1 publication

Non-hemodynamic factors associated to the risk of developing hypertensive cardiopathy

Non-hemodynamic factors associated to the risk of developing hypertensive cardiopathy

Canadian Cardiovascular Society position statement – Recommendations for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease

Elevation of HDL-C in Response to Statin Treatment is Involved in the Regression of Carotid Atherosclerosis

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