Low incidence and high remission of allergic sensitization among adults

Warm, Katja; Bäckman, Helena; Lindberg, Anne; Lundbäck, Bo; Rönmark, Eva

doi:10.1016/j.jaci.2011.08.033

Cited by 59 publications

(62 citation statements)

References 35 publications

(51 reference statements)

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“…The reason for this is unclear, but we have in a previous publication reported high remission of allergic sensitization among elderly people. 8 Thus, subjects who had allergic rhinitis at a young age may have outgrown the allergic component but the rhinitis has remained as a nonallergic rhinitis. This is in line with a long-term follow-up of adults with rhinitis.…”

Section: Discussionmentioning

confidence: 99%

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Allergic sensitization is age-dependently associated with rhinitis, but less so with asthma

Warm

Hedman

Lindberg

et al. 2015

Journal of Allergy and Clinical Immunology

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Section: Discussionmentioning

confidence: 99%

“…[6][7][8] Normal aging partly explains the decrease in the prevalence of allergic sensitization with increasing age among adults, 8 and a cohort effect may contribute as well. 9 Similarly, the prevalence of allergic rhinitis is known to increase from childhood and adolescence to young adulthood, and thereafter it decreases by increasing age.…”

mentioning

confidence: 99%

Allergic sensitization is age-dependently associated with rhinitis, but less so with asthma

Warm

Hedman

Lindberg

et al. 2015

Journal of Allergy and Clinical Immunology

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“…Allergy skin testing (prick and intracutaneous) or serum testing for specific IgE is used to assess allergen sensitization to environmental allergens. Allergen sensitization as well as total IgE, has been shown to diminish with age [6-8]. …”

Section: Types Of Rhinitis In the Elderlymentioning

confidence: 99%

Rhinitis in the Elderly

Baptist

Nyenhuis

2016

Immunology and Allergy Clinics of North America

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By the year 2050, the US aging population will nearly double. As the US aging population grows, it will be increasingly important for healthcare providers to effectively diagnose and manage rhinitis. The nasal symptoms of rhinorrhea, congestion, sneezing, nasal/ocular pruritus, and postnasal drainage affect up to 32% of older adults, and can significantly impact the quality of life. Several underlying factors associated with aging (such as structural changes and immunosenescence) may contribute to the pathogenesis of rhinitis in older adults. Although treatment options for rhinitis exist, special considerations need to be made as comorbidities, limited income, memory loss, and side effects of medications frequently occur in older adults and may impact outcomes.

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“…The natural history of prevalence of aeroallergen IgE sensitisation has been examined in longitudinal studies in adults [12]–[18], but the results are contradictory and show the prevalence decreasing [15], [18], remaining stable [12], [19] or increasing [13], [14], [16], [17] over time.…”

Section: Introductionmentioning

confidence: 99%

Natural History of Perceived Food Hypersensitivity and IgE Sensitisation to Food Allergens in a Cohort of Adults

et al. 2014

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BackgroundNo longitudinal studies exist on the natural history of food hypersensitivity and IgE sensitisation to food allergens in adults.ObjectiveTo examine the natural history of food hypersensitivity, the natural history of IgE sensitisation to food allergens and to investigate the risk factors for new onset food hypersensitivity.MethodsFood hypersensitivity was questionnaire-assessed in 2307 individuals (aged 20–45 years) from Iceland and Sweden during the European Community Respiratory Health Survey both at baseline and follow-up 9 years later. IgE food and aeroallergen sensitisation were assessed in a subgroup of these individuals (n = 807). Values of 0.35 kU/L and above were regarded as positive sensitisation.ResultsFood hypersensitivity was reported by 21% of the subjects and this proportion remained unchanged at follow-up (p = 0.58). Fruits, nuts and vegetables were the three most common causes of food hypersensitivity, with a similar prevalence at baseline and follow-up. The prevalence IgE sensitisation to food allergens decreased in general by 56% (p<0.001) and IgE sensitisation to peanut decreased in particular by 67% (p = 0.003). The prevalence of timothy grass IgE sensitisation decreased by 15% (p = 0.003) while cat, mite and birch IgE sensitisation did not decrease significantly. Female sex, rhinitis, eczema and presence of IgE sensitisation to aeroallergens were independently associated with new onset food hypersensitivity.ConclusionThe prevalence of food hypersensitivity remained unchanged while the prevalence of IgE sensitisation to food allergens decreased in adults over a 9-year follow-up period. The decrease in prevalence of IgE sensitisation to food allergens was considerably larger than the change in prevalence of IgE sensitisation to aeroallergens.

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Low incidence and high remission of allergic sensitization among adults

Cited by 59 publications

References 35 publications

Allergic sensitization is age-dependently associated with rhinitis, but less so with asthma

Allergic sensitization is age-dependently associated with rhinitis, but less so with asthma

Rhinitis in the Elderly

Natural History of Perceived Food Hypersensitivity and IgE Sensitisation to Food Allergens in a Cohort of Adults

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