Low Incidence of Helicobacter pylori Infection in Patients with Duodenal Ulcer and Chronic Liver Disease

Abstract

DU in patients with CLD is not different clinically from those without CLD. Omeprazole effectively and safely treats DU in CLD. Nitric oxide and free oxygen radicals may result in gastric mucosal changes in CLD similar to that caused by H. pylori.

Helicobacter pylori Infection and Peptic Ulcer Disease in Patients with Liver Cirrhosis

“…Moreover, the prevalence of H. pylori infection in cirrhotic patients in our study was significantly lower than that in the control and reference groups, a finding that was different from that found by many groups 6 , 7 , 13 - 18 , 23 , 24) . It was consistent with the results of others 19 , 20) . This relatively low prevalence of H. pylori infection in cirrhotic patients in our study can be explained by the enrollment of more than 50% of Child-Pugh B and C cirrhotic patients in our study.…”

Oesophagogastroduodenoscopy in patients with cirrhosis: Extending the range of detection beyond portal hypertension

“…Several studies have reported either increased or similar prevalence of H. pylori in cirrhotics when compared with controls [35,39,42,43]. In our study, overall prevalence of H. pylori infection was 75% consistent with literature data, but only 47% of peptic ulcers were related to H. pylori, such relatively low prevalence can be partially explained by the different methods used for the diagnosis of H. pylori infection, indeed, serologic studies reported higher prevalence than studies that used invasive methods [39,[42][43][44][45]. Another reason could be that only 0.8% of our patients presented dyspeptic symptoms at the time of EGD.…”

Review article: Helicobacter pylori‐negative duodenal ulcer disease

“…pylori’ OR ‘Helicobacter pylori’) AND ‘duodenal ulcer’. Studies evaluating the H. pylori prevalence in patients with DU and published during the last 10 years (from 1999 to 2008) are summarized in Table 1 10–82 . Those studies where all patients had concomitant diseases (such as malignancy, chronic renal failure, liver cirrhosis, etc.)…”

“…The presence of concomitant diseases is an independent predictive factor for non‐ H. pylori peptic ulcer, as several diseases (malignancy, diabetes mellitus, chronic obstructive airway disease, cerebrovascular accident, chronic renal failure, liver cirrhosis, etc.) increase the risk of developing ulcer disease through pathogenic mechanisms different from H. pylori infection 26, 34 . In some studies, more than half of patients with non‐ H. pylori , non‐NSAID DUs had concomitant diseases 37, 112 .…”