Low incidence of malignancy in heart-transplant recipients in Taiwan: an update and comparison with kidney-transplant recipients

Hsu, Ron‐Bin; Chang, Chung-I; Tsai, Min Kuang; Lee, Po‐Huang; Chou, Nai‐Kuan; Chi, Nai‐Hsin; Wang, Shoei‐Shen; Chu, Shu‐Hsun

doi:10.1016/j.ejcts.2009.11.028

Cited by 15 publications

(5 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar results of a low risk of skin cancer in Asian people after heart and kidney transplantation have been reported in several studies. 21 – 24 The incidence of skin cancer in the general population is believed to be higher in Western people than in Asian people because of differences in ethnic factors and skin type. Different from Western people, Chinese people do not have an increased risk of developing skin cancer while receiving immunosuppressive treatments after solid organ transplantation.…”

Section: Discussionmentioning

confidence: 99%

Post-Transplant Malignancy in Liver Transplantation

Hsiao¹,

Lee²,

Ho³

et al. 2014

Medicine

Self Cite

View full text Add to dashboard Cite

We aim to determine the incidence of malignancy after liver transplantation (LT) compared to general population.The records of patients who received LTs at our center from October 1989 and November 2012 were retrospectively reviewed. The standardized incidence ratio (SIR) of cancer in the patients was compared to general population using the data from the Taiwan Cancer Registry. Survival was estimated using the Kaplan–Meier method.A total of 444 patients were included. Malignancy was found in 46 (28 de novo and 19 recurrent malignancies) patients (10.4%) with the median follow up of 4.2 ± 4.2 years. The median time of cancer occurrence after transplant was 1.2 ± 1.9 years (range, 0.2–9.1 years). Post-transplant lymphoproliferative disorder was the most frequent de novo malignancy (57.1% [16/28]). The cumulative incidence rates of all malignancies were 5.1%, 10.4%, 12.8%, 15.8%, and 15.8% at 1, 3, 5, 10, and 15 years, respectively. The cumulative incidence rates of de novo malignancies were 3.4%, 5.97%, 7.7%, 10.9%, and 10.9 % at 1, 3, 5, 10, and 15 years. Compared to general population, transplant recipients had significantly higher incidence of all de novo cancers (SIR: 3.26, 95% confidence interval [CI]: 2.17–4.72), hematologic (SIR: 58.4; 95% CI, 33.3–94.8), and bladder (SIR: 10.2, 95% CI: 1.1–36.7) cancers. The estimated mean survivals after transplantation in cancer-free, de novo cancer, and recurrent cancer patients were 17.7 ± 0.5, 11.3 ± 1.2, and 3.6 ± 0.6 years, respectively.There is a significantly increased risk of malignancies after LT in the Taiwanese population.

show abstract

Section: Discussionmentioning

confidence: 99%

Post-Transplant Malignancy in Liver Transplantation

Hsiao¹,

Lee²,

Ho³

et al. 2014

Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…Twenty‐two studies evaluated the risk of SCD in all patients undergoing transplantation, and 11 cohorts focused on patients surviving the early post‐transplant period with a pooled incidence rate of SCD of 1.30 per 100 person‐years (95% CI: 1.08‐1.52, I 2 = 75%; Figure ).…”

Section: Resultsmentioning

confidence: 99%

“…The remaining six (18%) studies were deemed low quality due to additional issues related to study attrition [9][10][11][12][13][14] and uncertain patient selection. [11][12][13][14] Twenty-two studies evaluated the risk of SCD in all patients undergoing transplantation, 6,[9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] The confidence in this evidence was deemed to be low based on the presence of risk of bias at the study level related to uncertainty around outcome ascertainment and publication bias ( Figure S1), which could have led to SCD risk overestimation. High heterogeneity across studies was explained to some extent by differences in proportion of patients with CAV and transplant era.…”

Section: Data Synthesis and Statistical Analysismentioning

confidence: 99%

“…and 11 cohorts focused on patients surviving the early post-transplant period[28][29][30][31][32][33][34][35][36][37][38][39] with a pooled incidence rate of SCD of 1.30 per 100 person-years (95% CI: 1.08-1.52, I 2 = 75%;Figure 2). By meta-regression, studies including a higher proportion of patients with CAV had a higher risk of SCD, explaining 25% of variation in SCD risk across studies (P = .03).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Incidence and predictors of sudden cardiac death after heart transplantation: A systematic review and meta‐analysis

Alba

Foroutan

Hing

et al. 2018

Clinical Transplantation

View full text Add to dashboard Cite

show abstract

“…Cancer incidence (8.3-8.8%) reported by other renal transplant centers in Taiwan were also comparable with our results. [9][10][11][12] It is suggested that transplant tourism was associated with a higher risk of de novo malignancy after renal transplantation. Transplant tourism may be a surrogate factor of many associated factors associated with post-transplant malignancy.…”

Section: Discussionmentioning

confidence: 99%

De novo malignancy is associated with renal transplant tourism

Tsai

Yang

Lee

et al. 2011

Kidney International

Self Cite

View full text Add to dashboard Cite

Despite the objections to transplant tourism raised by the transplant community, many patients continue travel to other countries to receive commercial transplants. To evaluate some long-term complications, we reviewed medical records of 215 Taiwanese patients (touring group) who received commercial cadaveric renal transplants in China and compared them with those of 321 transplant recipients receiving domestic cadaveric renal transplants (domestic group) over the same 20-year period. Ten years after transplant, the graft and patient survival rates of the touring group were 55 and 81.5%, respectively, compared with 60 and 89.3%, respectively, of the domestic group. The difference between the two groups was not statistically significant. The 10-year cumulative cancer incidence of the touring group (21.5%) was significantly higher than that of the domestic group (6.8%). Univariate and multivariate stepwise regression analyses (excluding time on immunosuppression, an uncontrollable factor) indicated that transplant tourism was associated with significantly higher cancer incidence. Older age at transplantation was associated with a significantly increased cancer risk; however, the risk of de novo malignancy significantly decreased with longer graft survival. Thus, renal transplant tourism may be associated with a higher risk of post-transplant malignancy, especially in patients of older age at transplantation.

show abstract

Low incidence of malignancy in heart-transplant recipients in Taiwan: an update and comparison with kidney-transplant recipients

Abstract: The incidence of post-transplant malignancy was low in Chinese heart-transplant recipients compared with heart-transplant recipients in Western countries. It resulted from a relative rarity of skin cancers in the Chinese population.

Cited by 15 publications

References 23 publications

Post-Transplant Malignancy in Liver Transplantation

Post-Transplant Malignancy in Liver Transplantation

Incidence and predictors of sudden cardiac death after heart transplantation: A systematic review and meta‐analysis

De novo malignancy is associated with renal transplant tourism

Contact Info

Product

Resources

About