Low incidence of sepsis due to viridans streptococci in a ten‐year retrospective study of pediatric acute myeloid leukemia

Abstract

The low rate of VGS and enterobacteriaceae sepsis was probably due to the effective decontamination. Our supportive care strategy could potentially help enhance overall survival in children with AML.

Clinical and Microbiologic Outcomes of Quinolone Prophylaxis in Children With Acute Myeloid Leukemia

“…38,39 Implementation of supportive care strategies such as decontamination of gums and gastrointestinal tract has reportedly decreased the incidence of VGS bacteremia. 40 Although an increase of GPC bacteremia on quinolone prophylaxis has not been found by all, 5,17 prophylaxis directed against Gram-negative infections (ie, with quinolones) has been identified as a risk factor for infections with VGS. 22,28,[41][42][43][44] We found that CPx was effective in decreasing aminoglycoside use, most likely because the incidence of GNR infections was lower.…”

Microbiologically documented infections and infection-related mortality in children with acute myeloid leukemia

“…5 Similarly, a single institution study found that 5 (6.4%) of 78 of their children with AML died of infection. 6 The reason for higher infection-related mortality on CCG 2961 may be related to the intensely myelosuppressive nature of this chemotherapy regimen. Alternatively, in intensive Other enterobacteriaceae For personal use only.…”

High frequency of streptococcal bacteraemia during childhood AML therapy irrespective of dose of cytarabine

“…Each febrile episode requiring hospitalisation and empiric intravenous antibiotic therapy was counted as a separate infection and categorized as a bloodstream infection (BSI), local infection, or fever of unknown origin (FUO). Bloodstream infections were defined as fever with at least one positive blood culture of bacteria or fungi 18. Multiple organisms from the same patient within the same treatment block were considered separate infections, except for polymicrobial bloodstream infections, which were defined as two or more microorganisms isolated from a single blood culture 19.…”