Low incidence of significant dysplasia in a successful endoscopic surveillance program of patients with ulcerative colitis

Rozen, Paul; Baratz, M; Fefer, Fred; Gilat, Tuvia

doi:10.1016/0016-5085(95)90683-5

Cited by 101 publications

(46 citation statements)

References 34 publications

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“…Some groups argue that performing colonoscopy every 2-3 years, with interven ing flexible sigmoidoscopy, is a less invasive and less expensive option [43,60]. However, with this protocol, there is a significant risk of missing right-sided dysplasia, or even carcino ma, that may develop in the interval [54],…”

Section: Managem Entmentioning

confidence: 99%

Inflammatory Bowel Disease and Colon Cancer: A Review

Jain

Peppercorn²

1997

Dig Dis

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Extensive and long-standing colitis due to Crohn’s disease and ulcerative colitis is associated with an increased incidence of colorectal cancer. Colonoscopy with biopsies for mucosal dysplasia can help stratify those patients who are at increased risk. However, the effectiveness of surveillance programs has been questioned. Newer molecular techniques may eventually lead to the development of more accurate screening tools, but at this time there is not enough evidence to support their widespread use.

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Section: Managem Entmentioning

confidence: 99%

Inflammatory Bowel Disease and Colon Cancer: A Review

Jain

Peppercorn²

1997

Dig Dis

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“…The grade of dysplasia was determined according to the classification proposed by Riddell et al 3 Because the clinical implication of Bindefinite for dysplasia^is controversial 24 and because the verification of significant dysplasia was the main goal of surveillance in UC, we revised and simplified histologic diagnosis for dysplasia to make it negative (negative or indefinite for dysplasia) or positive (low-grade or high-grade dysplasia).…”

Section: Histologic Examinationmentioning

confidence: 99%

Hypermethylation of p14 ARF May Be Predictive of Colitic Cancer in Patients with Ulcerative Colitis

Moriyama¹,

Matsumoto²,

Nakamura³

et al. 2007

Diseases of the Colon &Amp; Rectum

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“…It is generally accepted that patients who have had UC for at least seven to eight years are at risk for developing carcinoma and should be entered into a colonoscopic surveillance program (58, 68, 79 -81). The incidence of dysplasia in UC is difficult to estimate; studies suggest a 5% incidence of dysplasia after ten years and a 25% incidence after 20 years (80,(82)(83)(84)(85). The cumulative incidence of colorectal cancer after 25-35 years of UC ranges from 3.1% to 43%.…”

Section: Dysplasia In Ulcerative Colitismentioning

confidence: 99%