Low-intensity exercise training decreases cardiac output  and hypertension in spontaneously hypertensive rats

Véras-Silva, Acácio Salvador; Mattos, Katt Coelho; Gava, Nilo Sérgio; Brum, Patrícia Chakur; Negräo, Carlos Eduardo; Krieger, Eduardo Moacyr

doi:10.1152/ajpheart.1997.273.6.h2627

Cited by 163 publications

(172 citation statements)

References 21 publications

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“…Aerobic training is currently recommended as a potent coadjuvant of the pharmacological treatment of hypertension, mainly because it attenuates (but does not normalize) resting blood pressure in hypertensive animals (2,22,23,25,(34)(35)(36)(37)(38)(39) and humans (40,41).…”

Section: Mechanisms Conditioning Training-induced Hemodynamic Changesmentioning

confidence: 99%

Effect of gender on training-induced vascular remodeling in SHR

Amaral

Michelini

2011

Braz J Med Biol Res

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There is accumulating evidence that physical inactivity, associated with the modern sedentary lifestyle, is a major determinant of hypertension. It represents the most important modifiable risk factor for cardiovascular diseases, which are the leading cause of morbidity and mortality for both men and women. In addition to involving sympathetic overactivity that alters hemodynamic parameters, hypertension is accompanied by several abnormalities in the skeletal muscle circulation including vessel rarefaction and increased arteriole wall-to-lumen ratio, which contribute to increased total peripheral resistance. Low-intensity aerobic training is a promising tool for the prevention, treatment and control of high blood pressure, but its efficacy may differ between men and women and between male and female animals. This review focuses on peripheral training-induced adaptations that contribute to a blood pressure-lowering effect, with special attention to differential responses in male and female spontaneously hypertensive rats (SHR). Heart, diaphragm and skeletal muscle arterioles (but not kidney arterioles) undergo eutrophic outward remodeling in trained male SHR, which contributed to a reduction of peripheral resistance and to a pressure fall. In contrast, trained female SHR showed no change in arteriole wall-to-lumen ratio and no pressure fall. On the other hand, training-induced adaptive changes in capillaries and venules (increased density) were similar in male and female SHR, supporting a similar hyperemic response to exercise.

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Section: Mechanisms Conditioning Training-induced Hemodynamic Changesmentioning

confidence: 99%

Effect of gender on training-induced vascular remodeling in SHR

Amaral

Michelini

2011

Braz J Med Biol Res

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“…[5][6][7] Favourable modifications in autonomic modulation and BP have been documented following endurance training in animals and humans. [8][9][10][11][12] Our prior study has demonstrated an augmentation in parasympathetic or vagal modulation and enhanced baroreflex sensitivity (BRS) and arterial compliance (AC) following aerobic training. [13][14][15][16][17][18][19][20][21] Not surprisingly, few of these studies assessed these effects in African-American men, not in populations other than whites.…”

Section: Introductionmentioning

confidence: 99%

Exercise training favourably affects autonomic and blood pressure responses during mental and physical stressors in African-American men

et al. 2008

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Aerobic exercise is a powerful mechanism by which cardiovascular and autonomic parameters may be improved. We sought to quantify the extent of benefit that could be achieved by a short-term monitored exercise regimen on several autonomic parameters during recognized mental and physical stressors in young normotensive African-American men matched for a family history of hypertension, a group at high risk for the development of hypertension. Autonomic modulations were derived using spectral decomposition of the electrocardiogram and beat-to-beat blood pressures (BPs). Arterial compliance was obtained using contour analysis of the radial artery pulse wave. The analysis of variance revealed that compared with a matched sedentary control group, aerobic capacity of the trained group significantly increased by 16%. Autonomic modulations, arterial compliance and BP responses significantly improved during some of the stressors, whereas no such improvements were seen in the control group. Attenuated responses, mediated through a favourable shift in sympathovagal balance and enhanced arterial compliance, provide mechanistic evidence of how certain variables may be improved due to aerobic conditioning in a population at high risk for the development of hypertension.

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“…The heart rate seems to be reduced by low-intensity exercise training in SHR, likely due to a decrease in the sympathetic tone to the heart (17). This effect has been also attributed to causing the decrease in the cardiac output in low-intensity exercise-trained SHR and, consequently, for reducing the hypertension (46). Postexercise hypotension may persist for more than 12 h (16,19), and it has been reported that arterial baroreceptor reflex is required for this reduction in arterial pressure (7), but all of the mechanisms underlying this effect are not fully understood.…”

mentioning

confidence: 97%

Exercise changes regional vascular control by commissural NTS in spontaneously hypertensive rats

Ogihara

Schoorlemmer

Levada

et al. 2010

American Journal of Physiology-Regulatory, Integrative and Comp

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Ogihara CA, Schoorlemmer GHM, Levada AC, Pithon-Curi TC, Curi R, Lopes OU, Colombari E, Sato MA. Exercise changes regional vascular control by commissural NTS in spontaneously hypertensive rats. Am J Physiol Regul Integr Comp Physiol 299: R291-R297, 2010. First published April 21, 2010 doi:10.1152/ajpregu.00055.2009.-Inhibition of the commissural nucleus of the solitary tract (commNTS) induces a fall in sympathetic nerve activity and blood pressure in spontaneously hypertensive rats (SHR), which suggests that this subnucleus of the NTS is a source of sympathoexcitation. Exercise training reduces sympathetic activity and arterial pressure. The purpose of the present study was to investigate whether the swimming exercise can modify the regional vascular responses evoked by inhibition of the commNTS neurons in SHR and normotensive Wistar-Kyoto (WKY) rats. Exercise consisted of swimming, 1 h/day, 5 days/wk for 6 wks, with a load of 2% of the body weight. The day after the last exercise session, the rats were anesthetized with intravenous ␣-chloralose, tracheostomized, and artificially ventilated. The femoral artery was cannulated for mean arterial pressure (MAP) and heart rate recordings, and Doppler flow probes were placed around the lower abdominal aorta and superior mesenteric artery. Microinjection of 50 mM GABA into the commNTS caused similar reductions in MAP in swimming and sedentary SHR (Ϫ25 Ϯ 6 and Ϫ30 Ϯ 5 mmHg, respectively), but hindlimb vascular conductance increased twofold in exercised vs. sedentary SHR (54 Ϯ 8 vs. 24 Ϯ 5%). GABA into the commNTS caused smaller reductions in MAP in swimming and sedentary WKY rats (Ϫ20 Ϯ 4 and Ϫ16 Ϯ 2 mmHg). Hindlimb conductance increased fourfold in exercised vs. sedentary WKY rats (75 Ϯ 2% vs. 19 Ϯ 3%). Therefore, our data suggest that the swimming exercise induced changes in commNTS neurons, as shown by a greater enhancement of hindlimb vasodilatation in WKY vs. SHR rats in response to GABAergic inhibition of these neurons.GABA; cardiovascular; citrate synthase THE NUCLEUS OF THE SOLITARY tract (NTS) is the primary site in the central nervous system that receives the afferents arising from arterial baro-and chemoreceptors (10, 15). The intermediate NTS receives inputs particularly from arterial baroreceptors, but some of these afferents achieve the commNTS (10, 16). The commNTS also receives inputs from arterial chemoreceptors, and seems to be highly sensitive to carotid chemoreceptor stimulation (8, 9, 11).The possible role of the commNTS as a source of sympathoexcitation was first shown by Nelson et al. (33), which demonstrated that nanoliter injections of L-glutamate into the commNTS evoke elevations in heart rate and arterial pressure mediated by the sympathetic nervous system. Electrolytic lesions or chemical inhibition of the commNTS have been shown to markedly decrease the splanchnic sympathetic nerve activity and arterial pressure in spontaneously hypertensive rats (SHR), which suggested that this subnucleus of the NTS contains neurons tonically active in S...

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Low-intensity exercise training decreases cardiac output and hypertension in spontaneously hypertensive rats

Cited by 163 publications

References 21 publications

Effect of gender on training-induced vascular remodeling in SHR

Effect of gender on training-induced vascular remodeling in SHR

Exercise training favourably affects autonomic and blood pressure responses during mental and physical stressors in African-American men

Exercise changes regional vascular control by commissural NTS in spontaneously hypertensive rats

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