Low‐intensity extracorporeal shockwave therapy for diabetic men with erectile dysfunction: A systematic scoping review

Mason, Matthew M.; Pai, Raghav; Masterson, John M.; Lokeshwar, Soum D.; Chu, Kevin Y.; Ramasamy, Ranjith

doi:10.1111/andr.13197

Cited by 15 publications

(14 citation statements)

References 47 publications

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“…In addition, in a systematic review of the literature in the comparisons of LiESWT and PDE5Is versus PDE5Is alone for post‐prostatectomy ED patients, some studies supported a statistically significant improvement in EF with LiESWT and PDE5Is, although several limitations such as small sample sizes, high risk of bias, and high heterogeneity among the studies existed 15 . Furthermore, it was reported that LiESWT may be an effective targeted treatment modality for patients with diabetes 16 . Thus, LiESWT may have the potential to cure not only vasculogenic ED but also neurogenic ED.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and patient satisfaction of low‐intensity shockwave treatment for erectile dysfunction in a retrospective real‐world study in Japan

et al. 2022

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Objectives: To clarify the efficacy of low-intensity extracorporeal shockwave therapy for patients with erectile dysfunction, compare the efficacy between two types of lithotripters (ED1000 [focused type] and Renova [linear type]), and detect factors indicative of therapeutic gain with the treatment. Methods: This retrospective study included 76 patients (52.8 AE 11.7 years) treated by ED1000 (12 times over 9 weeks) and 484 patients (52.5 AE 11.6 years) treated by Renova (4 times over 4 weeks). Age, sexual symptoms scores, and blood examinations were assessed. Efficacy was judged by improvement of the scores and patient satisfaction and compared between patients at 1 month after treatment with the lithotripters. Independent factors influencing efficacy by Renova were also assessed. Results: Sexual symptom scores were improved significantly by both lithotripters, although the changes in the scores did not differ significantly between them. Efficacy rate as judged by patient satisfaction was 65.8% with the ED1000 and 71.1% with Renova, also without significant difference. Among several factors including age, sexual symptoms scores, endocrinological factors, metabolic factors, and the rate of phosphodiesterase type 5 inhibitor use, only age was found to be an independent factor influencing the efficacy of Renova. Conclusion:We clearly showed the high efficacy of both lithotripters. Although the efficacy rate did not differ between them, we speculated that the fewer treatment sessions needed with the Renova versus the ED1000 would be a great advantage for patients. We also suggest that Renova should be recommended for patients younger than 70 years of age.

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Section: Discussionmentioning

confidence: 99%

Efficacy and patient satisfaction of low‐intensity shockwave treatment for erectile dysfunction in a retrospective real‐world study in Japan

et al. 2022

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“…systematically reviewed animal and clinical studies related to the use of Li‐ESWT for treatment of DM‐related ED 11 . Here, Li‐ESWT is confirmed to be a safe and effective treatment in men with well‐controlled DM and ED 11 …”

Section: Diabetic Metabolic Dysregulation and Sexual Functionmentioning

confidence: 97%

Not only a matter of glucose: The andrological consequences of diabetes mellitus

Rastrelli

Santi

2023

Andrology

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“…The mechanism of Li-ESWT treatment for ED is still unknown. Its effects could be caused by the induction of mechanical stress, which could result in neovescularization, the recruitment of stem cells and growth factors, an improvement in blood flow, and nerve regeneration ( Gruenwald et al, 2013 ; Mason et al, 2022 ). Some studies have shown that Li- ESWT can promote the expression of neuronal nitric oxide synthase (nNOS) in endothelial cells, smooth muscle cells, and nerve cells ( Yao et al, 2022 ).…”

Section: Physical Therapy Of Edmentioning

confidence: 99%

Advances in physical diagnosis and treatment of male erectile dysfunction

Pang

Pan

et al. 2023

Front. Physiol.

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Erectile dysfunction (ED) is the most common male sexual dysfunction by far and the prevalence is increasing year after year. As technology advances, a wide range of physical diagnosis tools and therapeutic approaches have been developed for ED. At present, typical diagnostic devices include erection basic parameter measuring instrument, erection hardness quantitative analysis system, hemodynamic testing equipment, nocturnal erection measuring instrument, nerve conduction testing equipment, etc. At present, the most commonly used treatment for ED is pharmacological therapy represented by phosphodiesterase five inhibitors (PDE5i). As a first-line drug in clinical, PDE5i has outstanding clinical effects, but there are still some problems that deserve the attention of researchers, such as cost issues and some side effects, like visual disturbances, indigestion, myalgia, and back pain, as well as some non-response rates. Some patients have to consider alternative treatments. Moreover, the efficacy in some angiogenic EDs (diabetes and cardiovascular disease) has not met expectations, so there is still a need to continuously develop new methods that can improve hemodynamics. While drug have now been shown to be effective in treating ED, they only control symptoms and do not restore function in most cases. The increasing prevalence of ED also makes us more motivated to find safer, more effective, and simpler treatments. The exploration of relevant mechanisms can also serve as a springboard for the development of more clinically meaningful physiotherapy approaches. Therefore, people are currently devoted to studying the effects of physical therapy and physical therapy combined with drug therapy on ED. We reviewed the diagnosis of ED and related physical therapy methods, and explored the pathogenesis of ED. In our opinion, these treatment methods could help many ED patients recover fully or partially from ED within the next few decades.

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Low‐intensity extracorporeal shockwave therapy for diabetic men with erectile dysfunction: A systematic scoping review

Cited by 15 publications

References 47 publications

Efficacy and patient satisfaction of low‐intensity shockwave treatment for erectile dysfunction in a retrospective real‐world study in Japan

Efficacy and patient satisfaction of low‐intensity shockwave treatment for erectile dysfunction in a retrospective real‐world study in Japan

Not only a matter of glucose: The andrological consequences of diabetes mellitus

Advances in physical diagnosis and treatment of male erectile dysfunction

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