Low-Intensity Pulsed Ultrasound Accelerates Healing in Rat Calcaneus Tendon Injuries

Combined Therapy (Ultrasound and Interferential Current) in Patients with Fibromyalgia: Once or Twice in a Week?

“…This can explain the focal sustained contraction and the favourable appearance of TP. Therefore, US can promote benefits in FM patients because it can promote angiogenesis (Barzelai et al, 2006), tissue healing (Jeremias Júnior et al, 2011), muscle relaxation (Srbely and Dickey, 2007) and an increase in metabolism and permeability of cell membrane (Mortimer and Dyson, 1988). Although reduction of muscular pain caused by the constant contraction of muscles can be attributed to the therapeutic effects of pulsed US, controversies still remain regarding its effect on myofascial pain (Srbely et al, 2009;Rickards, 2006).…”

Low-intensity pulsed ultrasound promotes cell motility through vinculin-controlled Rac1 GTPase activity

“…Many in vivo studies have demonstrated that LIPUS can be beneficial in improving healing in several other tissue types, including the skin wounds of diabetic and aged mice by increasing fibroblast migration into the wound site (Roper et al, 2015), ischemic heart disease by increasing angiogenesis (Hanawa et al, 2014), tendon repair (Jeremias Junior et al, 2011;Lu et al, 2016) by increasing collagen synthesis (Fu et al, 2010), and muscle repair after injury by increasing myofibre regeneration .…”

Low Intensity Ultrasound for Promoting Soft Tissue Healing: A Systematic Review of the Literature and Medical Technology

“…Rupture strength in tendons treated with LITUS was significantly greater than controls from 5 to 42 days post-injury ( p <0.05; 16-18,21-23 Tensile strength and tendon extensibility in LITUS-treated tendons was also higher than in control tendons. 16,22-25 Collagen synthesis, measured by conversion of radiolabeled proline to hydroxyproline, increased substantially from day 3 to day 5 post-injury and continued to show benefits through day 21 compared to controls ( p <0.05; 17,18 Collagen type I and III expression was greater following LITUS treatment, 26 and higher birefringence (i.e., coherence of collagen alignment) was also observed in treated tendons compared to controls. 27,28 Additionally, an examination of treatment time and duration found that introducing LITUS in the earlier stages of healing increased tensile strength and matrix synthesis compared to the later stages of healing.…”

“…Injured tendons treated with LITUS recover with greater tensile strength and extensibility than similar tendons that received no treatment post-injury. 16,22-25 Recovering tendons treated with LITUS had greater amounts of collagen,. 26 and improved organization and aggregation of collagen bundles.…”