Low-intensity Pulsed Ultrasound Improves Erectile Function in Streptozotocin-induced Type I Diabetic Rats

Lei, Hongen; Hua, Xing; Guan, Ruili; Xu, Yongde; Li, Huixi; Tian, Wenjie; Wang, Lin; Gao, Zhiqiang; Guo, Yinglu; Lue, Tom F.; Lin, Guiting; Xin, Zhongcheng

doi:10.1016/j.urology.2015.07.026

Cited by 55 publications

(43 citation statements)

References 22 publications

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“…Band intensity was quantified by densitometry (Quantity One, version 4.6.1). The values were normalized to GAPDH, and these results were expressed as fold change …”

Section: Methodsmentioning

confidence: 99%

Effects of silodosin, a selective alpha‐1A adrenoceptor antagonist, on erectile function in a rat model of partial bladder outlet obstruction

Bastaskin

Kaya

Özakça

et al. 2016

Neurourology and Urodynamics

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“…Band intensity was quantified by densitometry (Quantity One, version 4.6.1). The values were normalized to GAPDH, and these results were expressed as fold change …”

Section: Methodsmentioning

confidence: 99%

Effects of silodosin, a selective alpha‐1A adrenoceptor antagonist, on erectile function in a rat model of partial bladder outlet obstruction

Bastaskin

Kaya

Özakça

et al. 2016

Neurourology and Urodynamics

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“…In this context, LESW increased diabetic rats' gastric motility, and the effect had a decreasing trend after 2, 4, and 6 weeks of LESW. However, there is a need for further study for clarification because only a few studies clarify the effect of LESW on neuromuscular systems in other organs . After LESW therapy, we found more neuron, synaptophysin, and choline acetyltransferase expression on a gastric i.m.…”

Section: Discussionmentioning

confidence: 84%

“…However, there is a need for further study for clarification because only a few studies clarify the effect of LESW on neuromuscular systems in other organs. [22][23][24] After Figure 4 (a) After induced as diabetic rats, decreased gastric contractions were noted in diabetic rats than controls (11.00 ± 0.60: 15.00 ± 0.40 times/5 min, P = 0.006). After low-energy extracorporeal shock wave (LESW) intervention, we found increased gastric contraction in diabetic rats than diabetic rats' post-sham procedure (14.60 ± 0.20: 11.00 ± 0.50 times/5 min, P = 0.002 after 2 weeks LESW; 14.40 ± 0.40: 11.20 ± 0.20 times/5 min, P = 0.001 after 4 weeks LESW).…”

Section: Discussionmentioning

confidence: 94%

Effect of extracorporeal low‐energy shock wave on diabetic gastroparesis in a rat model

Chiu

Yao

et al. 2018

J of Gastro and Hepatol

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“…LESWT, which is typically defined as an energy flux density <0.1 mJ mm −2 , can improve the erectile function of diabetic rats by promoting the regeneration of endothelial cells, smooth muscle cells, and exerting anti-fibrotic effects 192021. In addition to improving angiogenesis, the mechanism of action of LESWT might be related to the recruitment of endogenetic stem cells 22.…”

Section: Introductionmentioning

confidence: 99%

Combination of low-energy shock-wave therapy and bone marrow mesenchymal stem cell transplantation to improve the erectile function of diabetic rats

Shan

Zhang

Chen³

et al. 2017

Asian J Androl

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Stem cell transplantation and low-energy shock-wave therapy (LESWT) have emerged as potential and effective treatment protocols for diabetic erectile dysfunction. During the tracking of transplanted stem cells in diabetic erectile dysfunction models, the number of visible stem cells was rather low and decreased quickly. LESWT could recruit endogenous stem cells to the cavernous body and improve the microenvironment in diabetic cavernous tissue. Thus, we deduced that LESWT might benefit transplanted stem cell survival and improve the effects of stem cell transplantation. In this research, 42 streptozotocin-induced diabetic rats were randomized into four groups: the diabetic group (n = 6), the LESWT group (n = 6), the bone marrow-derived mesenchymal stem cell (BMSC) transplantation group (n = 15), and the combination of LESWT and BMSC transplantation group (n = 15). One and three days after BMSC transplantation, three rats were randomly chosen to observe the survival numbers of BMSCs in the cavernous body. Four weeks after BMSC transplantation, the following parameters were assessed: the surviving number of transplanted BMSCs in the cavernous tissue, erectile function, real-time polymerase chain reaction, and penile immunohistochemical assessment. Our research found that LESWT favored the survival of transplanted BMSCs in the cavernous body, which might be related to increased stromal cell-derived factor-1 expression and the enhancement of angiogenesis in the diabetic cavernous tissue. The combination of LESWT and BMSC transplantation could improve the erectile function of diabetic erectile function rats more effectively than LESWT or BMSC transplantation performed alone.

show abstract

Low-intensity Pulsed Ultrasound Improves Erectile Function in Streptozotocin-induced Type I Diabetic Rats

Cited by 55 publications

References 22 publications

Effects of silodosin, a selective alpha‐1A adrenoceptor antagonist, on erectile function in a rat model of partial bladder outlet obstruction

Effects of silodosin, a selective alpha‐1A adrenoceptor antagonist, on erectile function in a rat model of partial bladder outlet obstruction

Effect of extracorporeal low‐energy shock wave on diabetic gastroparesis in a rat model

Combination of low-energy shock-wave therapy and bone marrow mesenchymal stem cell transplantation to improve the erectile function of diabetic rats

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