Low-Level Environmental Heavy Metals are Associated with Obesity Among Postmenopausal Women in a Southern State

Stahr, Shelbie; Chiang, Tung-Chin; Bauer, Michael; Runnells, Gail; Rogers, Lora J.; Vi, Huyen; Kadlubar, Susan; Su, L. Joseph

doi:10.1007/s12403-020-00381-6

Cited by 18 publications

(8 citation statements)

References 48 publications

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“…Despite consideration of As as a potential obesogen [43], existing epidemiological data are insufficient and contradictory. A recent study demonstrated that salivary As levels are directly associated with BMI in women [44]. In contrast, urinary As concentration was characterized by inverse association with BMI in Taiwanese subjects [45].…”

Section: Discussionmentioning

confidence: 98%

Hair Lead, Aluminum, and Other Toxic Metals in Normal-Weight and Obese Patients with Coronary Heart Disease

Skalny

Kopylov

Paoliello

et al. 2021

IJERPH

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The objective of the present study was to evaluate hair toxic metal levels in patients with obesity and/or coronary heart disease (CHD). Following a 2 × 2 factorial design, subjects without CHD were grouped into normal weight control (n = 123) and obese groups (n = 140). Patients suffering from CHD were divided into normal weight (n = 180) and obese CHD subjects (n = 240). Hair Al, As, Cd, Hg, Ni, and Pb levels were evaluated using inductively-coupled plasma mass-spectrometry. The data demonstrate that hair Al and Hg levels were higher in obese subjects as compared to normal weight controls. Normal weight CHD patients were characterized by significantly higher hair Al, As, Cd, and Pb levels when compared to healthy subjects. The highest hair Al, As, and Pb levels were observed in obese CHD patients, significantly exceeding the respective values in other groups. Factorial analysis revealed significant influence of factorial interaction (CHD*obesity) only for hair Pb content. Given the role of obesity as a risk factor for CHD, it is proposed that increased toxic metal accumulation in obesity may promote further development of cardiovascular diseases.

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Section: Discussionmentioning

confidence: 98%

Hair Lead, Aluminum, and Other Toxic Metals in Normal-Weight and Obese Patients with Coronary Heart Disease

Skalny

Kopylov

Paoliello

et al. 2021

IJERPH

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…”

Section: Methodsmentioning

confidence: 99%

weight gain velocity goodbreak= \frac{weight at N weeks - weight at M weeks}{weight at M weeks} goodbreak\times 100 % .

…”

Section: Methodsmentioning

confidence: 99%

“…Physiological criteria, including body and thymus weight, were determined following the methods described by Farhangi et al (2017) and Kong et al (2018). The weight gain velocity (Sié et al, 2021;Stahr et al, 2021) was calculated with the formula below: when: N > 2, M = N-2; N = 1, M = 0, Next-generation sequencing (NGS) of the 16S rRNA gene amplicons method was utilized to check the gut microbiota in the intestinal contents collected from three mice (they were selected from every group randomly).…”

Section: Chemical Composition Of Dwp and Dwppmentioning

confidence: 99%

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Donkey whey protein and peptides regulate gut microbiota community and physiological functions of D‐galactose‐induced aging mice

Zhou

Tian

Li³

et al. 2022

Food Science & Nutrition

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The prolongation of life span has attracted more and more attention in the current world. Gut microbiota is considered one of the most critical elements and is essential in regulating life span and quality. The effects of donkey whey protein (DWP) and donkey whey hydrolysate (DWPP) on physiological functions and gut microbiota of D‐galactose‐induced aging mice were investigated to find new strategies for resisting aging. Our results showed that DWP and DWPP could increase the body weight gain velocity, superoxide dismutase (SOD) activity, and thymus index, whereas decrease the level of reactive oxygen species (ROS) and malondialdehyde (MDA), and improve the aging of the body in the liver congestion, oozy draw focal sclerosis of chronic inflammation. The effects of medium and high concentrations of DWP and low and medium concentrations of DWPP were the same as the vitamin C (Vc)‐positive control group. It was found that both DWP and DWPP could change α‐diversity; the relative abundance of Lactobacillus increased, whereas the relative abundance of Helicobacter and Stenotrophomonas decreased after being treated with DWP and DWPP. The correlation between intestinal microflora and physiological indexes showed that chao1, ACE, and observed species indexes in the α index were positively correlated with weight gain velocity, SOD activity, and thymus index. The relative abundance of Lactobacillus was positively correlated with SOD and thymus index but negatively correlated with MDA. The relative abundance of Stenotrophomonas was opposite to that of Lactobacillus . The Anaerobiospirillum , Fusobacterium , and Dubosiella had a significant positive correlation with the weight gain velocity. The study provided a deeper more profound understanding of the potential use of DWP and DWPP in senescence delays.

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“…To date, numerous studies have revealed a significant association between metal(loid)s, such as lead, cadmium, and mercury, and obesity as defined by abnormal BMI. − However, research on the association between exposure to metal(loid)s and WC or AOB defined by abnormal WC is limited. BMI is a common indicator of obesity, reflecting overall body fat, while WC provides insight into the status of visceral fat and abdominal adipose tissue .…”

Section: Introductionmentioning

confidence: 99%

Why Do People Gain Belly Fat in Rural Areas? A Study of Urinary Metal(loid)s and Abdominal Obesity in China

Hao

et al. 2023

Environ. Sci. Technol.

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Obesity is prevalent in rural areas of China, and there are inconsistent findings regarding the association between metal(loid) exposure and the risk of obesity. Abdominal obesity (AOB), which reflects visceral fat abnormity, is a crucial factor in studying obesity-related diseases. We conducted a study measuring 20 urinary metal(loid)s, 13 health indicators, and the waist circumference (WC) in 1849 participants from 10 rural areas of China to investigate their relationships. In the single exposure models, we found that urinary chromium (Cr) was significantly associated with the odds of having AOB [adjusted odds ratio (OR) = 1.81 (95% confidence interval (CI): 1.24, 2.60)]. In the mixture exposure models, urinary Cr consistently emerged as the top contributor to AOB, while the overall effect of mixed metal(loid)s was positive toward the odds of having AOB [adjusted OR: 1.33 (95% CI: 1.00, 1.77)], as revealed from the quantile g-computation model. After adjusting for the effects of other metal(loid)s, we found that the elevation of apolipoprotein B and systolic blood pressure significantly mediated the association between urinary Cr and the odds of having AOB by 9.7 and 19.4%, respectively. Our results suggest that exposure to metal(loid)s is a key factor contributing to the prevalence of AOB and WC gain in rural areas of China.

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Low-Level Environmental Heavy Metals are Associated with Obesity Among Postmenopausal Women in a Southern State

Cited by 18 publications

References 48 publications

Hair Lead, Aluminum, and Other Toxic Metals in Normal-Weight and Obese Patients with Coronary Heart Disease

Hair Lead, Aluminum, and Other Toxic Metals in Normal-Weight and Obese Patients with Coronary Heart Disease

Donkey whey protein and peptides regulate gut microbiota community and physiological functions of D‐galactose‐induced aging mice

Why Do People Gain Belly Fat in Rural Areas? A Study of Urinary Metal(loid)s and Abdominal Obesity in China

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