Low-Level Laser Therapy Applied Transcranially to Rats After Induction of Stroke Significantly Reduces Long-Term Neurological Deficits

Oron, Amir; Oron, Uri; Chen, Jieli; Eilam, Anda; Zhang, Chunyu; Sadeh, Menachem; Lampl, Yair; Streeter, Jackson; Taboada, Luis De; Chopp, Michael

doi:10.1161/01.str.0000242775.14642.b8

Cited by 248 publications

(211 citation statements)

References 20 publications

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“…23 This effect was partially attributed to a significant increase in the number of intact mitochondria and ATP content, as well as to antioxidative enzyme activity in LELI induced hearts of rats and dogs as compared with non-irradiated hearts. LELI applied transcranially six hours postembolic stroke in rabbits and 24 hours postischemic stroke in rats caused a significant improvement in the neurological score over sham-operated experimental animals, 24 a finding that has been confirmed by others. 25 It is thought that LELI causes suppression of nitric oxide synthase activity and upregulation of TGF-β1, which are considered neurotoxic and neuroprotective, respectively.…”

Section: Low-energy Laser Irradiationsupporting

confidence: 71%

A historical perspective towards a non-invasive treatment for patients with atherosclerosis

Slijkhuis¹,

Mali²,

Appelman³

2009

NHJL

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The history of atherosclerosis and cardiovascular disease dates back to ancient times. From the teachings of Galen to the response-to-injury hypothesis of Russel Ross, we have now arrived at the concept of the vulnerable plaque. Next to the development of new treatment options for patients with atherosclerosis, also novel diagnostic imaging techniques have been developed to visualise the arterial wall and to characterise plaque composition. In this article the historical context of atherosclerosis and the attempts towards a noninvasive therapy for patients with atherosclerotic diseases are described. (Neth Heart J 2009;17: 140-5.)

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Section: Low-energy Laser Irradiationsupporting

confidence: 71%

A historical perspective towards a non-invasive treatment for patients with atherosclerosis

Slijkhuis¹,

Mali²,

Appelman³

2009

NHJL

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“…839 The postulated mechanism of action is photobiostimulation, with near-infrared radiation absorbed by mitochondrial chromophores, which accelerates enzymatic activity, increases adenosine triphosphate production, and promotes tissue preservation in the ischemic penumbra and enhanced neurorecovery. [840][841][842] Evidence of benefit in animal models [843][844][845][846] led to a safety and preliminary efficacy trial in 120 patients with acute ischemic stroke, which demonstrated statistically better outcomes in the treated patients as measured by the NIHSS, mRS, Barthel index, and Glasgow Outcome Scale. 847 A confirmatory trial enrolling 660 patients reported a positive trend but not a definitive benefit, and an additional pivotal trial using refined selection criteria is planned.…”

Section: Near-infrared Laser Therapymentioning

confidence: 99%

Guidelines for the Early Management of Patients With Acute Ischemic Stroke

Jauch¹,

Saver²,

Adams³

et al. 2013

Stroke

5,370

1,801

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Background and Purpose-The authors present an overview of the current evidence and management recommendations for evaluation and treatment of adults with acute ischemic stroke. The intended audiences are prehospital care providers, physicians, allied health professionals, and hospital administrators responsible for the care of acute ischemic stroke patients within the first 48 hours from stroke onset. These guidelines supersede the prior 2007 guidelines and 2009 updates. Methods-Members of the writing committee were appointed by the American Stroke Association Stroke Council's Scientific Statement Oversight Committee, representing various areas of medical expertise. Strict adherence to the American Heart Association conflict of interest policy was maintained throughout the consensus process. Panel members were assigned topics relevant to their areas of expertise, reviewed the stroke literature with emphasis on publications since the prior guidelines, and drafted recommendations in accordance with the American Heart Association Stroke Council's Level of Evidence grading algorithm. Results-The goal of these guidelines is to limit the morbidity and mortality associated with stroke. The guidelines support the overarching concept of stroke systems of care and detail aspects of stroke care from patient recognition; emergency medical services activation, transport, and triage; through the initial hours in the emergency department and stroke unit. The guideline discusses early stroke evaluation and general medical care, as well as ischemic stroke, specific interventions such as reperfusion strategies, and general physiological optimization for cerebral resuscitation. The American Heart Association makes every effort to avoid any actual or potential conflicts of interest that may arise as a result of an outside relationship or a personal, professional, or business interest of a member of the writing panel. Specifically, all members of the writing group are required to complete and submit a Disclosure Questionnaire showing all such relationships that might be perceived as real or potential conflicts of interest. Guidelines for the Early Management of PatientsThis statement was approved by the American Heart Association Science Advisory and Coordinating Committee on December 12, 2012. A copy of the document is available at http://my.americanheart.org/statements by selecting either the "By Topic" link or the "By Publication Date" link. To purchase additional reprints, call 843-216-2533 or e-mail kelle.ramsay@wolterskluwer.com.The Executive Summary is available as an online-only Data Supplement with this article at http://stroke.ahajournals.org/lookup/suppl/ doi:10.1161/STR.0b013e318284056a/-/DC1.The American Heart Association requests that this document be cited as follows: Jauch EC, Saver JL, Adams HP Jr, Bruno A, Connors JJ, Demaerschalk BM, Khatri P, McMullan PW Jr, Qureshi AI, Rosenfield K, Scott PA, Summers DR, Wang DZ, Wintermark M, Yonas H; on behalf of the American Heart Association Stroke Council, Council on Cardio...

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“…26 Finally, several groups have suggested that NIr promotes functional recovery by stimulating neurogenesis and neuronal migration. 8,19,29 It remains to be determined which of these mechanisms protects SNc cells, but our working hypothesis is that they are not mutually exclusive and that they all contribute to the process. 39 We are currently exploring this issue of NIr mechanisms in other studies.…”

Section: Neuroprotection Of Dopaminergic Cells In the Snc Via Nir Aftmentioning

confidence: 99%

Photobiomodulation inside the brain: a novel method of applying near-infrared light intracranially and its impact on dopaminergic cell survival in MPTP-treated mice

Moro

Massri²,

Torres

et al. 2014

JNS

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Object Previous experimental studies have documented the neuroprotection of damaged or diseased cells after applying, from outside the brain, near-infrared light (NIr) to the brain by using external light-emitting diodes (LEDs) or laser devices. In the present study, the authors describe an effective and reliable surgical method of applying to the brain, from inside the brain, NIr to the brain. They developed a novel internal surgical device that delivers the NIr to brain regions very close to target damaged or diseased cells. They suggest that this device will be useful in applying NIr within the large human brain, particularly if the target cells have a very deep location. Methods An optical fiber linked to an LED or laser device was surgically implanted into the lateral ventricle of BALB/c mice or Sprague-Dawley rats. The authors explored the feasibility of the internal device, measured the NIr signal through living tissue, looked for evidence of toxicity at doses higher than those required for neuroprotection, and confirmed the neuroprotective effect of NIr on dopaminergic cells in the substantia nigra pars compacta (SNc) in an acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of Parkinson disease in mice. Results The device was stable in freely moving animals, and the NIr filled the cranial cavity. Measurements showed that the NIr intensity declined as distance from the source increased across the brain (65% per mm) but was detectable up to 10 mm away. At neuroprotective (0.16 mW) and much higher (67 mW) intensities, the NIr caused no observable behavioral deficits, nor was there evidence of tissue necrosis at the fiber tip, where radiation was most intense. Finally, the intracranially delivered NIr protected SNc cells against MPTP insult; there were consistently more dopaminergic cells in MPTP-treated mice irradiated with NIr than in those that were not irradiated. Conclusions In summary, the authors showed that NIr can be applied intracranially, does not have toxic side effects, and is neuroprotective.

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Low-Level Laser Therapy Applied Transcranially to Rats After Induction of Stroke Significantly Reduces Long-Term Neurological Deficits

Cited by 248 publications

References 20 publications

A historical perspective towards a non-invasive treatment for patients with atherosclerosis

A historical perspective towards a non-invasive treatment for patients with atherosclerosis

Guidelines for the Early Management of Patients With Acute Ischemic Stroke

Photobiomodulation inside the brain: a novel method of applying near-infrared light intracranially and its impact on dopaminergic cell survival in MPTP-treated mice

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