Low-level laser therapy attenuates lung inflammation and airway remodeling in a murine model of idiopathic pulmonary fibrosis: Relevance to cytokines secretion from lung structural cells

Brito, Auriléia Aparecida de; Silveira, Elaine Cristina da; Rigonato‐Oliveira, Nicole Cristine; Soares, Stephanie; Brandão-Rangel, Maysa Alves Rodrigues; Soares, Clariana; Santos, Tawany Gonçalves; Alves, Cintia Estefano; Herculano, Karine Zanella; Vieira, Rodolfo Paula; Lino-dos-Santos-Franco, Adriana; Albertini, Regiane; Aimbire, Flávio; Oliveira, Ana Paula de

doi:10.1016/j.jphotobiol.2019.111731

Cited by 35 publications

(42 citation statements)

References 51 publications

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“…Another study of the same murine model showed that infrared 780 nm light reduced inflammation and collagen deposits in the lungs of mice, downregulated pro-inflammatory cytokines, and upregulated the secretion of IL-10 from fibroblasts and pneumocytes. Moreover, it significantly reduced total lung TGFβ [87]. Taken together, these early results suggest that red and near infrared light have the potential to reduce some of the critical complications of coronavirus infections, i.e., pulmonary inflammation and lung fibrosis.…”

Section: Photobiomodulation and Acute Pulmonary Disordermentioning

confidence: 71%

“…There are indications that Acute Respiratory Distress Syndrome (ARDS) a critical complication of COVID-19 infection [81,84], often characterized by airway edema, pulmonary inflammation, and lung fibrosis, could be ameliorated with photobiomodulation, as evidenced by early results in laboratory animals [85][86][87]. For example, following induction of pulmonary inflammation in rats, de Lima et al [85] showed that irradiation of the skin over the inflamed bronchus with a single dose of 1.3 J cm −2 of continuous wave (CW) red 650 nm laser administered 1 h after induction of inflammation, inhibited pulmonary edema and downregulated several measures of inflammation.…”

Section: Photobiomodulation and Acute Pulmonary Disordermentioning

confidence: 99%

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Light as a potential treatment for pandemic coronavirus infections: A perspective

Enwemeka

Bumah

Masson-Meyers

2020

Journal of Photochemistry and Photobiology B: Biology

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Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Section: Photobiomodulation and Acute Pulmonary Disordermentioning

confidence: 71%

Section: Photobiomodulation and Acute Pulmonary Disordermentioning

confidence: 99%

Light as a potential treatment for pandemic coronavirus infections: A perspective

Enwemeka

Bumah

Masson-Meyers

2020

Journal of Photochemistry and Photobiology B: Biology

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“…Laboratory experiments show that light in the blue 400 -470 nm range is antimicrobial against numerous bacteria [14] [34] and has the potential to reduce opportunistic bacterial infections associated with SARS-CoV-2 and other coronavirus infections, as well as red light and near infrared at wavelengths in the range of 600 to 700 nm and 700 to 1000 nm, respectively, where they have the potential to reduce pulmonary inflammation and fibrosis [35] [36] [37]. Based on these studies, the use of these wavelengths is suggested to inactivate the virus [18] and to treat its complications, such as acute respiratory distress syndrome (ARDS) [4], one of the main causes of death in all coronavirus pandemics, including the SARS-CoV-2 pandemic [36] [37].…”

Section: Discussionmentioning

confidence: 99%

Photodynamic Therapy with Phthalomethyl D: Perspectives against SARS-CoV-2

Pinto¹,

Silva²,

Sampaio³

et al. 2020

JBM

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Background: Photodynamic therapy (PDT) is the generation of cytotoxic agents through the dynamic interaction between a photosensitizer excited by light at a specific wavelength. When associated with phthalocyanines, they are efficient in incorporating target cells and exhibiting high rates of triplet generation. This study aimed to characterize PDT associated with the phototherapeutic agent Phthalomethyl D, developed by the authors, in the process of repair, healing and immune improvement for possible application against SARS-CoV-2. Methods: Sixty-nine mice were used, divided into 2 groups: GI, treated with ILIB laser, without a phototherapeutic agent, and subjected to surgery for viral induction; GII, same as GI plus association of Phthalomethyl D. They were divided into subgroups and reevaluated at 7, 14, and 21 days, and then divided into 3 subgroups of 6 animals each, subjected to treatment at 24 h, 48 h, 72 h, 5 and 7 days. Results: Both groups had a high rate of partial incision closure and acute inflammatory control. Microscopically, there was a greater amount of amorphous fundamental substance, fibrocytes, fibroblasts, and giant cells and reduction in the number of keratinocytes, in the amount of keratin, and epidermal thickness in GII than in GI. Conclusions: PDT with Phthalomethyl D stimulates the processes of healing/repair and immunomodulation during viral infection, initially favoring the inflammatory response and, after

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“…LLLT contributes to the resolution of inflammation by upregulating IL-10 and downregulating P2X7r. LLLT changes the profile of inflammatory cytokines and elevates IL-10 [26,31,36], known as human cytokine synthesis inhibitory factor, in the lung and abolishes lung inflammation via a reduction of inflammatory cytokines and mast cell degranulation [31]. LLLT decreases collagen deposition as well as the expression of the P2X7r [26].…”

Section: The Effects Of Lllt On Pulmonary Inflammationmentioning

confidence: 99%

“…In a model of acute lung injury, LLLT reduced DNA fragmentation and apoptotic pathways via increased B-cell-lymphoma-2 (Bcl-2), the key regulator of the intrinsic or mitochondrial pathway for apoptosis, in alveolar epithelial cells while promoting DNA fragmentation in inflammatory cells [37]. In pulmonary idiopathic fibrosis, LLLT inhibits pro-inflammatory cytokines and increases expression of proliferating cell nuclear antigen [38], attenuates airway remodeling by balancing pro-and anti-inflammatory cytokines in lung tissue, and inhibiting fibroblast secretion of the pro-fibrotic cytokines [36].…”

Section: The Effects Of Lllt On Pulmonary Inflammationmentioning

confidence: 99%

Low level laser therapy as a modality to attenuate cytokine storm at multiple levels, enhance recovery, and reduce the use of ventilators in COVID-19

Mokmeli¹,

Vetrici

2020

Can J Respir Ther

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The global pandemic COVID-19 is a contagious disease and its mortality rates ranging from 1% to 5% are likely due to acute respiratory distress syndrome (ARDS), and cytokine storm. A significant proportion of patients who require intubation succumb to the disease, despite the availability of ventilators and the best treatment practices. Researchers worldwide are in search of anti-inflammatory medicines in the hope of finding a cure for COVID-19. Low-level laser therapy (LLLT) has strong, anti-inflammatory effects confirmed by meta-analyses, and it may be therapeutic to ARDS. LLLT has been used for pain management, wound healing, and other health conditions by physicians, physiotherapists, and nurses worldwide for decades. In addition, it has been used in veterinary medicine for respiratory tract disease such as pneumonia. Laser light with low-power intensity is applied to the surface of the skin to produce local and systemic effects. Based on the clinical experience, peer-reviewed studies, and solid laboratory data in experimental animal models, LLLT attenuates cytokine storm at multiple levels and reduces the major inflammatory metabolites. LLLT is a safe, effective, low-cost modality without any side-effects that may be combined with conventional treatment of ARDS. We summarize the effects of LLLT on pulmonary inflammation and we provide a protocol for augmenting medical treatment in COVID-19 patients. LLLT combined with conventional medical therapy has the potential to prevent the progression of COVID-19, minimize the length of time needed on a ventilator, enhance the healing process, and shorten recovery time.

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Low-level laser therapy attenuates lung inflammation and airway remodeling in a murine model of idiopathic pulmonary fibrosis: Relevance to cytokines secretion from lung structural cells

Cited by 35 publications

References 51 publications

Light as a potential treatment for pandemic coronavirus infections: A perspective

Light as a potential treatment for pandemic coronavirus infections: A perspective

Photodynamic Therapy with Phthalomethyl D: Perspectives against SARS-CoV-2

Low level laser therapy as a modality to attenuate cytokine storm at multiple levels, enhance recovery, and reduce the use of ventilators in COVID-19

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