Low-Level Laser Therapy for Wound Healing

Posten, William; Wrone, David A.; Dover, Jeffrey S.; Arndt, Kenneth A.; Silapunt, Sirunya; Alam, Murad

doi:10.1097/00042728-200503000-00016

Cited by 299 publications

(36 citation statements)

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“…67 Finally, one should note that some of the effects of near-IR irradiation can be beneficial to cells rather than being toxic, and an extensive literature on near-IR and IR irradiationtriggered wound healing is available. 68 As noted above, mitochondria, and more particularly ATP synthesis and oxygen-consuming pathways, are sensitive to visible and near-IR irradiation. 69 In mice pre-exposed to IRA before UVB irradiation, the number of sunburn cells was reduced.…”

Section: Near Infrared and Infrared Light Toxicitymentioning

confidence: 93%

Shifting the Light Activation of Metallodrugs to the Red and Near-Infrared Region in Anticancer Phototherapy

Bonnet

2014

Comments on Inorganic Chemistry

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Section: Near Infrared and Infrared Light Toxicitymentioning

confidence: 93%

Shifting the Light Activation of Metallodrugs to the Red and Near-Infrared Region in Anticancer Phototherapy

Bonnet

2014

Comments on Inorganic Chemistry

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“…LLLT features irradiation with red or near‐infrared light. In contrast to most laser therapies, which deliver high energy causing tissue ablation or thermal coagulation, LLLT delivers lower energy; LLLT is often described as a “cold laser” because tissue is not damaged by elevated temperatures .…”

Section: Introductionmentioning

confidence: 99%

Light‐emitting diode irradiation using 660 nm promotes human fibroblast HSP90 expression and changes cellular activity and morphology

Choi

Chang

Biswas

et al. 2019

Journal of Biophotonics

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We evaluated changes in cell viability and morphology in response to low‐level light irradiation and underlying variations in the levels of heat shock proteins (HSPs). Human fibroblasts were irradiated with a light‐emitting diode (LED) array at 660 nm (50 mW for 15, 30, and 60 minutes). Cell viability and morphological changes were evaluated via epifluorescence analysis; we also assessed cell viability and length changes. The expression levels of adenosine triphosphate (ATP) and various HSPs (HSP27, 60, 70, and 90) were analyzed by immunohistochemical staining, Western blotting and microarray analysis. After LED irradiation, cellular viability and morphology changed. Of the several HSPs analyzed, the HSP90 level increased significantly, suggesting that this protein played roles in the morphological and cellular changes. Thus, low‐level irradiation triggered cellular changes mediated by increased HSP90 expression; this may explain why skin irradiation enhances wound‐healing.

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“…Light exposures which mitigated the side effects of drugs, toxins, and ionizing radiation exposures are referenced in [84][85][86][87][88]. Laser treatments for rheumatoid arthritis, healing of wounds, diseases and burns are referenced in [89][90][91][92][93][94][95][96][97][98][99][100][101]. References are also included to early work [102][103][104][105][106][107][108][109][110][111][112] to investigate hydrogen peroxide, how to refine early measurement techniques and quantify the amount of hydrogen peroxide created in animals and humans.…”

Section: Introductionmentioning

confidence: 99%

Laser therapy: A review of its mechanism of action and potential medical applications

Tata

Waynant

2010

Laser & Photonics Reviews

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Civilizations in antiquity have endeavored to champion the use of light to treat illnesses in the human body. Although laser light has unique applications in medicine, its mechanism of action for low intensity exposures on cells, tissues, and the body continues to be controversial after nearly 50 years of investigations. This paper presents evidence for visible red and near infrared light to induce (indirect) generation of hydrogen peroxide as an important chemical messenger behind the stimulatory and inhibitory responses observed to low intensity light exposures. It is hypothesized that other ionizing or non-ionizing modalities can either directly or indirectly induce / or generate H 2 O 2 in an aqueous environment and could also bring about similar stimulatory or inhibitory bioeffects. One salient parameter which governs the bio-response is the level of generated H 2 O 2 . The authors discuss the mechanism which enables a small amount of hydrogen peroxide generated by light to produce beneficial effects.

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Low-Level Laser Therapy for Wound Healing

Cited by 299 publications

References 0 publications

Shifting the Light Activation of Metallodrugs to the Red and Near-Infrared Region in Anticancer Phototherapy

Shifting the Light Activation of Metallodrugs to the Red and Near-Infrared Region in Anticancer Phototherapy

Light‐emitting diode irradiation using 660 nm promotes human fibroblast HSP90 expression and changes cellular activity and morphology

Laser therapy: A review of its mechanism of action and potential medical applications

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