Low-level laser therapy improves repair following complete resection of the sciatic nerve in rats

Abstract

The aim of this study is to analyze the effects of low-level laser therapy (LLLT) on the regeneration of the sciatic nerve in rats following a complete nerve resection. Male Wistar rats were divided into a control injury group, injury groups irradiated with a 660-nm laser at 10 or 50 J/cm(2), and injury groups irradiated with an 808-nm laser at 10 or 50 J/cm(2). Treatment began 24 h following nerve resection and continued for 15 days. Using the sciatic functional index (SFI), we show that the injured animals treated with 660 nm at 10 and 50 J/cm(2) had better SFI values compared with the control injury and the 808-nm groups. Animals irradiated with the 808-nm laser at 50 J/cm(2) show higher values for fiber density than do control animals. In addition, axon and fiber diameters were larger in animals irradiated with 660 nm at 50 J/cm(2) compared to the control group. These findings indicate that 660-nm LLLT is able to provide functional gait recovery and leads to increases in fiber diameter following sciatic nerve resection.

Effect of low-level laser therapy (LLLT) on peripheral nerve regeneration using fibrin glue derived from snake venom

“…The laser has biostimulator effect on peripheral nerve repair, as it helps to improve blood supply, cell proliferation and collagen synthesis. In addition, the therapy provides analgesic, anti-inflammatory and anti-edema effects [14][15][16][17][18][19][20][21][22].…”

Low-level laser therapy alleviates mechanical and cold allodynia induced by oxaliplatin administration in rats

“…Many studies have also reported positive effects for LLLT in improving neuropathic pain, promoting functional recovery of peripheral nerves, and accelerating axonal growth and regeneration [20][21][22][23]. It has been recommended that LLLT should be started as soon as possible during the acute phase of nerve injury, due to its modulatory actions on inflammation [24].…”

Flexible nine-channel photodetector probe facilitated intraspinal multisite transcutaneous photobiomodulation therapy dosimetry in cadaver dogs

“…4 The regenerative responses of the axon under photobiomodulatory doses of light, 5 most commonly at 810 nm in studies performed on rodent models, [6][7][8] are particularly promising for treating spinal cord diseases that are difficult to access anatomically and therapeutically. However, in spite of the obvious potential for the treatment regimen, PBMT for spinal cord disease remains clinically untested.…”